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Volumn , Issue , 2006, Pages 201-220

The platelet P2 receptors

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EID: 33646254999     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369367-9/50772-2     Document Type: Chapter
Times cited : (5)

References (210)
  • 1
    • 0037304906 scopus 로고    scopus 로고
    • Characterization of the UDPglucose receptor (re-named the P2Y14 receptor) adds diversity to the P2Y receptor family
    • P. Abbracchio, M. Boeynaems, A. Barnard, L. Boyer and C. Kennedy (2003) Characterization of the UDPglucose receptor (re-named the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci 24 52-55.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 52-55
    • Abbracchio, P.1    Boeynaems, M.2    Barnard, A.3    Boyer, L.4    Kennedy, C.5
  • 5
    • 0002832642 scopus 로고
    • Stimulus-response coupling mechanisms
    • D.R. Phillips, M.A. Shuman (Eds), Orlando, FL: Academic Press
    • E.M. Huang and T.C. Detwiler (1986) Stimulus-response coupling mechanisms. D.R. Phillips, M.A. Shuman (Eds) Biochemistry of platelets Orlando, FL: Academic Press. 1-68.
    • (1986) Biochemistry of platelets , pp. 1-68
    • Huang, E.M.1    Detwiler, T.C.2
  • 6
    • 0027199259 scopus 로고
    • The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionised calcium
    • C.R. Falcon, M. Cattaneo, A. Ghidoni and P.M. Mannucci (1993) The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionised calcium. Thromb Haemost 70 389-392.
    • (1993) Thromb Haemost , vol.70 , pp. 389-392
    • Falcon, C.R.1    Cattaneo, M.2    Ghidoni, A.3    Mannucci, P.M.4
  • 7
    • 0016690361 scopus 로고
    • Factors responsible for ADP-induced release reaction of human platelets
    • J.F. Mustard, D.W. Perry, R.L. Kinlough-Rathbone and M.A. Packham (1975) Factors responsible for ADP-induced release reaction of human platelets. Am J Physiol 228 1757-1765.
    • (1975) Am J Physiol , vol.228 , pp. 1757-1765
    • Mustard, J.F.1    Perry, D.W.2    Kinlough-Rathbone, R.L.3    Packham, M.A.4
  • 8
    • 18044398016 scopus 로고    scopus 로고
    • Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: A historical perspective
    • M.A. Packham and J.F. Mustard (2005) Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: A historical perspective. Semin Thromb Hemost 31 129-138.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 129-138
    • Packham, M.A.1    Mustard, J.F.2
  • 9
    • 8344227006 scopus 로고    scopus 로고
    • Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets
    • M. Cattaneo, C. Gachet, J.P. Cazenave and M.A. Packham (2002) Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets. Blood 99 3868-3869.
    • (2002) Blood , vol.99 , pp. 3868-3869
    • Cattaneo, M.1    Gachet, C.2    Cazenave, J.P.3    Packham, M.A.4
  • 10
    • 0032858002 scopus 로고    scopus 로고
    • ADP receptors and clinical bleeding disorders
    • M. Cattaneo and C. Gachet (1999) ADP receptors and clinical bleeding disorders. Arterioscler Thromb Vasc Biol 19 2281-2285.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 2281-2285
    • Cattaneo, M.1    Gachet, C.2
  • 13
    • 13044263119 scopus 로고    scopus 로고
    • A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    • C. Trumel, B. Payrastre, M. Plantavid, B. Hechler, C. Viala, P. Presek, E.A. Martinson, J.P. Cazenave, H. Chap and C. Gachet (1999) A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 94 4156-4165.
    • (1999) Blood , vol.94 , pp. 4156-4165
    • Trumel, C.1    Payrastre, B.2    Plantavid, M.3    Hechler, B.4    Viala, C.5    Presek, P.6    Martinson, E.A.7    Cazenave, J.P.8    Chap, H.9    Gachet, C.10
  • 14
    • 0030470605 scopus 로고    scopus 로고
    • ADP receptors on platelets
    • D.C. Mills (1996) ADP receptors on platelets. Thromb Haemost 76 835-856.
    • (1996) Thromb Haemost , vol.76 , pp. 835-856
    • Mills, D.C.1
  • 15
    • 0025233713 scopus 로고
    • Aggregin: A platelet ADP receptor that mediates aggregation
    • R.W. Colman (1990) Aggregin: A platelet ADP receptor that mediates aggregation. FASEB J 3 1425-1435.
    • (1990) FASEB J , vol.3 , pp. 1425-1435
    • Colman, R.W.1
  • 16
    • 0025737983 scopus 로고
    • Identifi cation of a nucleotide binding site on glycoprotein IIb. Relationship to platelet activation
    • N.J. Greco, N.N. Yamamoto, B. Jackson, N.N. Tandon, M.J. Moos and G.A. Jamieson (1991) Identifi cation of a nucleotide binding site on glycoprotein IIb. Relationship to platelet activation. J Biol Chem 266 13627-13633.
    • (1991) J Biol Chem , vol.266 , pp. 13627-13633
    • Greco, N.J.1    Yamamoto, N.N.2    Jackson, B.3    Tandon, N.N.4    Moos, M.J.5    Jamieson, G.A.6
  • 17
    • 0020051406 scopus 로고
    • Adenosine diphosphate antagonists and human platelets: No evidence that aggregation and inhibition of adenylate cyclase are mediated by different receptors
    • N.J. Cusack and S.M.O. Hourani (1982) Adenosine diphosphate antagonists and human platelets: No evidence that aggregation and inhibition of adenylate cyclase are mediated by different receptors. Br J Pharmacol 76 221-227.
    • (1982) Br J Pharmacol , vol.76 , pp. 221-227
    • Cusack, N.J.1    Hourani, S.M.O.2
  • 18
    • 0029765524 scopus 로고    scopus 로고
    • Effects of 2-methylthioadenosine 5.í, γ-methylenetriphosphonate and 2-ethylthioadenosine 5.-monophosphate on human platelet aggregation induced by adenosine 5.-diphosphate
    • S.M.O. Hourani, L.A. Welford and N.J. Cusack (1996) Effects of 2-methylthioadenosine 5.í, γ-methylenetriphosphonate and 2-ethylthioadenosine 5.-monophosphate on human platelet aggregation induced by adenosine 5.-diphosphate. Drug Dev Res 38 12-23.
    • (1996) Drug Dev Res , vol.38 , pp. 12-23
    • Hourani, S.M.O.1    Welford, L.A.2    Cusack, N.J.3
  • 19
    • 0019479293 scopus 로고
    • Inhibition by ADP of prostaglandin induced accumulation of cyclic AMP in intact human platelets
    • D.E. Macfarlane and D.C. Mills (1981) Inhibition by ADP of prostaglandin induced accumulation of cyclic AMP in intact human platelets. J Cyclic Nucleotide Res 7(1), 1-11.
    • (1981) J Cyclic Nucleotide Res , vol.7 , Issue.1 , pp. 1-11
    • Macfarlane, D.E.1    Mills, D.C.2
  • 20
    • 0020662261 scopus 로고
    • 2-Methylthio-adenosine[beta32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets
    • D.E. MacFarlane, P.C. Srivastava and D.C. Mills (1983) 2-Methylthio-adenosine[beta32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J Clin Invest 71 420-428.
    • (1983) J Clin Invest , vol.71 , pp. 420-428
    • MacFarlane, D.E.1    Srivastava, P.C.2    Mills, D.C.3
  • 21
    • 0030614527 scopus 로고    scopus 로고
    • The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
    • C. Léon, B. Hechler, C. Vial, C. Leray, J.P. Cazenave and C. Gachet (1997) The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett 403 26-30.
    • (1997) FEBS Lett , vol.403 , pp. 26-30
    • Léon, C.1    Hechler, B.2    Vial, C.3    Leray, C.4    Cazenave, J.P.5    Gachet, C.6
  • 22
    • 0033128384 scopus 로고    scopus 로고
    • The P2Y1 receptor is normal in a patient presenting a severe defi ciency of ADP-induced platelet aggregation
    • C. Leon, C. Vial, C. Gachet, P. Ohlmann, B. Hechler, J.P. Cazenave, A. Lecchi and M. Cattaneo (1999) The P2Y1 receptor is normal in a patient presenting a severe defi ciency of ADP-induced platelet aggregation. Thromb Haemost 81 775-781.
    • (1999) Thromb Haemost , vol.81 , pp. 775-781
    • Leon, C.1    Vial, C.2    Gachet, C.3    Ohlmann, P.4    Hechler, B.5    Cazenave, J.P.6    Lecchi, A.7    Cattaneo, M.8
  • 23
    • 0031593698 scopus 로고    scopus 로고
    • The P2Y1 receptor, necessary but not suffi cient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
    • B. Hechler, A. Eckly, P. Ohlmann, J.P. Cazenave and C. Gachet (1998) The P2Y1 receptor, necessary but not suffi cient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. Br J Haematol 103 858-866.
    • (1998) Br J Haematol , vol.103 , pp. 858-866
    • Hechler, B.1    Eckly, A.2    Ohlmann, P.3    Cazenave, J.P.4    Gachet, C.5
  • 24
    • 0031916728 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
    • J. Jin, J.L. Daniel and S.P. Kunapuli (1998) Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem 273 2030-2034.
    • (1998) J Biol Chem , vol.273 , pp. 2030-2034
    • Jin, J.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 26
    • 0031914973 scopus 로고    scopus 로고
    • Molecular basis for ADPinduced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
    • J.L. Daniel, C. Dangelmaier, J. Jin, B. Ashby, J.B. Smith and S.P. Kunapuli (1998) Molecular basis for ADPinduced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 273 2024-2029.
    • (1998) J Biol Chem , vol.273 , pp. 2024-2029
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3    Ashby, B.4    Smith, J.B.5    Kunapuli, S.P.6
  • 27
    • 0345368067 scopus 로고    scopus 로고
    • Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors
    • J. Geiger, P. Honig-Liedl, P. Schanzenbacher and U. Walter (1998) Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors. Eur J Pharmacol 351 235-246.
    • (1998) Eur J Pharmacol , vol.351 , pp. 235-246
    • Geiger, J.1    Honig-Liedl, P.2    Schanzenbacher, P.3    Walter, U.4
  • 32
    • 0032826036 scopus 로고    scopus 로고
    • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-defi cient mice
    • J.E. Fabre, M. Nguyen, A. Latour, J.A. Keifer, L.P. Audoly, T.M. Coffman and B.H. Koller (1999) Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-defi cient mice. Nat Med 5 1199-1202.
    • (1999) Nat Med , vol.5 , pp. 1199-1202
    • Fabre, J.E.1    Nguyen, M.2    Latour, A.3    Keifer, J.A.4    Audoly, L.P.5    Coffman, T.M.6    Koller, B.H.7
  • 35
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
    • J. Jin and S.P. Kunapuli (1998) Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci USA 95 8070-8074.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 36
    • 0014807470 scopus 로고
    • Factors infl uencing platelet function: Adhesion, release and aggregation
    • J.F. Mustard and M.A. Packham (1970) Factors infl uencing platelet function: Adhesion, release and aggregation. Pharmacol Rev 22 97-187.
    • (1970) Pharmacol Rev , vol.22 , pp. 97-187
    • Mustard, J.F.1    Packham, M.A.2
  • 37
    • 0016685182 scopus 로고
    • The effects of ATP on platelets: Evidence against the central role of released ADP in platelet aggregation
    • D.E. MacFarlane and D.C. Mills (1975) The effects of ATP on platelets: Evidence against the central role of released ADP in platelet aggregation. Blood 46 309-320.
    • (1975) Blood , vol.46 , pp. 309-320
    • MacFarlane, D.E.1    Mills, D.C.2
  • 38
    • 0035129349 scopus 로고    scopus 로고
    • Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP
    • M.G. Rolf, C.A. Brearley and M.P. Mahaut-Smith (2001) Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP. Thromb Haemost 85 303-308.
    • (2001) Thromb Haemost , vol.85 , pp. 303-308
    • Rolf, M.G.1    Brearley, C.A.2    Mahaut-Smith, M.P.3
  • 39
    • 18044382977 scopus 로고    scopus 로고
    • New insights into the role of P2X1 in platelet function
    • [abstract]
    • M. Cattaneo, P. Marchese, K.A. Jacobson and Z. Ruggeri (2002) New insights into the role of P2X1 in platelet function. Haematologica 87 13-14. [abstract]
    • (2002) Haematologica , vol.87 , pp. 13-14
    • Cattaneo, M.1    Marchese, P.2    Jacobson, K.A.3    Ruggeri, Z.4
  • 40
    • 4043133496 scopus 로고    scopus 로고
    • The P2X1 receptor for ATP plays an essential role in platelet aggregation at high shear
    • [abstract]
    • M. Cattaneo, P. Marchese, K.A. Jacobson and Z.M. Ruggeri (2003) The P2X1 receptor for ATP plays an essential role in platelet aggregation at high shear. Haematology J 4(Suppl 2), 150. [abstract]
    • (2003) Haematology J , vol.4 , pp. 150
    • Cattaneo, M.1    Marchese, P.2    Jacobson, K.A.3    Ruggeri, Z.M.4
  • 41
    • 0035164358 scopus 로고    scopus 로고
    • The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen
    • C. Oury, E. Toth-Zsamboki, C. Thys, J. Tytgat, J. Vermylen and M.F. Hoylaerts (2001) The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen. Thromb Haemost 86 1264-1271.
    • (2001) Thromb Haemost , vol.86 , pp. 1264-1271
    • Oury, C.1    Toth-Zsamboki, E.2    Thys, C.3    Tytgat, J.4    Vermylen, J.5    Hoylaerts, M.F.6
  • 42
    • 2942722488 scopus 로고    scopus 로고
    • ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation
    • C. Oury, E. Sticker, H. Cornelissen, R. De Vos, J. Vermylen and M.F. Hoylaerts (2004) ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation. J Biol Chem 279 26266-26273.
    • (2004) J Biol Chem , vol.279 , pp. 26266-26273
    • Oury, C.1    Sticker, E.2    Cornelissen, H.3    De Vos, R.4    Vermylen, J.5    Hoylaerts, M.F.6
  • 43
  • 46
    • 18044366362 scopus 로고    scopus 로고
    • Ectonucleotidases of CD39 family modulate vascular infl ammation and thrombosis an transplantation
    • S.C. Robson, Y. Wu, X. Sun, C. Knosalla, K. Dwyer and K. Eniyoji (2005) Ectonucleotidases of CD39 family modulate vascular infl ammation and thrombosis an transplantation. Semin Thromb Hemost 31 217-233.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 217-233
    • Robson, S.C.1    Wu, Y.2    Sun, X.3    Knosalla, C.4    Dwyer, K.5    Eniyoji, K.6
  • 47
    • 0343844465 scopus 로고    scopus 로고
    • Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor
    • C. Léon, C. Vial, J.P. Cazenave and C. Gachet (1996) Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene 171 295-297.
    • (1996) Gene , vol.171 , pp. 295-297
    • Léon, C.1    Vial, C.2    Cazenave, J.P.3    Gachet, C.4
  • 48
    • 0033591218 scopus 로고    scopus 로고
    • The role of aminoacids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes
    • C. Hoffman, S. Moro, R.A. Nicholas, T.K. Harden and K.A. Jacobson (1999) The role of aminoacids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. J Biol Chem 274 14639-14647.
    • (1999) J Biol Chem , vol.274 , pp. 14639-14647
    • Hoffman, C.1    Moro, S.2    Nicholas, R.A.3    Harden, T.K.4    Jacobson, K.A.5
  • 49
    • 0034125277 scopus 로고    scopus 로고
    • Advances in signalling by extracellular nucleotides. The role and transduction mechanisms of P2Y receptors
    • D. Communi, R. Janssens, N. Suarez-Huerta, B. Robaye and J.M. Boeynaems (2000) Advances in signalling by extracellular nucleotides. The role and transduction mechanisms of P2Y receptors. Cell Signal 12 351-360.
    • (2000) Cell Signal , vol.12 , pp. 351-360
    • Communi, D.1    Janssens, R.2    Suarez-Huerta, N.3    Robaye, B.4    Boeynaems, J.M.5
  • 50
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • V. Ralevic and G. Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50 413-492.
    • (1998) Pharmacol Rev , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 53
    • 0036245650 scopus 로고    scopus 로고
    • 2-Chloro N(6)-methyl-(N)-methanocarba-2.-deoxyadenosine-3.,5.-bisphosphate is a selective high affi nity P2Y(1) receptor antagonist
    • J.L. Boyer, M. Adams, R.G. Ravi, K.A. Jacobson and T.K. Harden (2002) 2-Chloro N(6)-methyl-(N)-methanocarba-2.-deoxyadenosine-3.,5.-bisphosphate is a selective high affi nity P2Y(1) receptor antagonist. Br J Pharmacol 135 1839-1840.
    • (2002) Br J Pharmacol , vol.135 , pp. 1839-1840
    • Boyer, J.L.1    Adams, M.2    Ravi, R.G.3    Jacobson, K.A.4    Harden, T.K.5
  • 55
    • 0033828240 scopus 로고    scopus 로고
    • Desensitization of the platelet aggregation response to ADP: Differential downregulation of the P2Y1 and P2cyc receptors
    • A. Baurand, A. Eckly, N. Bari, C. Leon, B. Hechler, J.P. Cazenave and C. Gachet (2000) Desensitization of the platelet aggregation response to ADP: Differential downregulation of the P2Y1 and P2cyc receptors. Thromb Haemost 84 484-491.
    • (2000) Thromb Haemost , vol.84 , pp. 484-491
    • Baurand, A.1    Eckly, A.2    Bari, N.3    Leon, C.4    Hechler, B.5    Cazenave, J.P.6    Gachet, C.7
  • 56
    • 14944348417 scopus 로고    scopus 로고
    • Differential regulation and relocalization of the platelet P2Y receptors after activation: A way to avoid loss of hemostatic properties?
    • A. Baurand, A. Eckly, B. Hechler, G. Kauffenstein, J.L. Galzi, J.P. Cazenave, C. Leon and C. Gachet (2005) Differential regulation and relocalization of the platelet P2Y receptors after activation: A way to avoid loss of hemostatic properties? Mol Pharmacol 67 721-733.
    • (2005) Mol Pharmacol , vol.67 , pp. 721-733
    • Baurand, A.1    Eckly, A.2    Hechler, B.3    Kauffenstein, G.4    Galzi, J.L.5    Cazenave, J.P.6    Leon, C.7    Gachet, C.8
  • 57
    • 0037440558 scopus 로고    scopus 로고
    • Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha-granules and the open canalicular system
    • P. Nurden, C. Poujol, J. Winckler, R. Combrie, N. Poussea, P.B. Conley, S. Levy-Toledano, A. Habib and A.T. Nurden (2003) Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha-granules and the open canalicular system. Blood 101 1400-1408.
    • (2003) Blood , vol.101 , pp. 1400-1408
    • Nurden, P.1    Poujol, C.2    Winckler, J.3    Combrie, R.4    Poussea, N.5    Conley, P.B.6    Levy-Toledano, S.7    Habib, A.8    Nurden, A.T.9
  • 58
    • 0034764926 scopus 로고    scopus 로고
    • Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP
    • B. Hechler, P. Toselli, C. Ravanat, C. Gachet and K. Ravid (2001) Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP. Mol Pharmacol 60 1112-1120.
    • (2001) Mol Pharmacol , vol.60 , pp. 1112-1120
    • Hechler, B.1    Toselli, P.2    Ravanat, C.3    Gachet, C.4    Ravid, K.5
  • 59
    • 0032105512 scopus 로고    scopus 로고
    • The P2Y1 receptor is necessary for adenosine 5.-diphosphate-induced platelet aggregation
    • B. Hechler, C. Léon, C. Vial, P. Vigne, C. Frelin, J.P. Cazenave and C. Gachet (1998) The P2Y1 receptor is necessary for adenosine 5.-diphosphate-induced platelet aggregation. Blood 92 152-159.
    • (1998) Blood , vol.92 , pp. 152-159
    • Hechler, B.1    Léon, C.2    Vial, C.3    Vigne, P.4    Frelin, C.5    Cazenave, J.P.6    Gachet, C.7
  • 60
    • 0026486964 scopus 로고
    • Identifi cation of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
    • M. Cattaneo, A. Lecchi, A.M. Randi, J.L. McGregor and P.M. Mannucci (1992) Identifi cation of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. Blood 80 2787-2796.
    • (1992) Blood , vol.80 , pp. 2787-2796
    • Cattaneo, M.1    Lecchi, A.2    Randi, A.M.3    McGregor, J.L.4    Mannucci, P.M.5
  • 61
    • 18044373075 scopus 로고    scopus 로고
    • The P2 receptors and congenital platelet function defects
    • M. Cattaneo (2005) The P2 receptors and congenital platelet function defects. Semin Thromb Hemost 31 168-173.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 168-173
    • Cattaneo, M.1
  • 63
  • 64
    • 13244253869 scopus 로고    scopus 로고
    • Different, G. protein-coupled signaling pathways are involved in alpha granule release from human platelets
    • T.M. Quinton, S. Murugappan, S. Kim, J. Jin and S.P. Kunapuli (2004) Different, G. protein-coupled signaling pathways are involved in alpha granule release from human platelets. J Thromb Haemost 2 978-984.
    • (2004) J Thromb Haemost , vol.2 , pp. 978-984
    • Quinton, T.M.1    Murugappan, S.2    Kim, S.3    Jin, J.4    Kunapuli, S.P.5
  • 65
    • 0012926596 scopus 로고    scopus 로고
    • Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice
    • B. Hechler, Y. Zhang, A. Eckly, J.P. Cazenave, C. Gachet and K. Ravid (2003) Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice. J Thromb Haemost 1 155-163.
    • (2003) J Thromb Haemost , vol.1 , pp. 155-163
    • Hechler, B.1    Zhang, Y.2    Eckly, A.3    Cazenave, J.P.4    Gachet, C.5    Ravid, K.6
  • 66
    • 0025124567 scopus 로고
    • ADP evokes biphasic Ca2+ infl ux in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store
    • S.O. Sage, R. Reast and T.J. Rink (1990) ADP evokes biphasic Ca2+ infl ux in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store. Biochem J 265 675-680.
    • (1990) Biochem J , vol.265 , pp. 675-680
    • Sage, S.O.1    Reast, R.2    Rink, T.J.3
  • 68
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in Galpha (q) -defi cient mice
    • S. Offermans, C.F. Toombs, Y.H. Hu and M.I. Simon (1997) Defective platelet activation in Galpha (q) -defi cient mice. Nature 389 183-186.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermans, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 69
    • 0034665782 scopus 로고    scopus 로고
    • ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq
    • P. Ohlmann, A. Eckly, M. Freund, J.P. Cazenave, S. Offermanns and C. Gachet (2000) ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq. Blood 96 2134-2139.
    • (2000) Blood , vol.96 , pp. 2134-2139
    • Ohlmann, P.1    Eckly, A.2    Freund, M.3    Cazenave, J.P.4    Offermanns, S.5    Gachet, C.6
  • 70
    • 0033214045 scopus 로고    scopus 로고
    • Platelet shape change is mediated by both calcium-dependent and-independent signalling pathways. Role of P160Rhoassociated coiled-coil-containing protein kinase in platelet shape change
    • B.Z. Paul, J.L. Daniel and S.P. Kunapuli (1999) Platelet shape change is mediated by both calcium-dependent and-independent signalling pathways. Role of P160Rhoassociated coiled-coil-containing protein kinase in platelet shape change. J Biol Chem 274 28293-28300.
    • (1999) J Biol Chem , vol.274 , pp. 28293-28300
    • Paul, B.Z.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 71
    • 0033199252 scopus 로고    scopus 로고
    • Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
    • M. Bauer, M. Retzer, J.I. Wilde, P. Maschberger, M. Essler, M. Aepfelbacher, S.P. Watson and W. Siess (1999) Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood 94 1665-1672.
    • (1999) Blood , vol.94 , pp. 1665-1672
    • Bauer, M.1    Retzer, M.2    Wilde, J.I.3    Maschberger, P.4    Essler, M.5    Aepfelbacher, M.6    Watson, S.P.7    Siess, W.8
  • 72
    • 0033835125 scopus 로고    scopus 로고
    • ADP-induced platelet shape change: An investigation of the signalling pathways involved and their dependence on the method of platelet preparation
    • J.I. Wilde, M. Retzer, W. Siess and S.P. Watson (2000) ADP-induced platelet shape change: An investigation of the signalling pathways involved and their dependence on the method of platelet preparation. Platelets 11 286-295.
    • (2000) Platelets , vol.11 , pp. 286-295
    • Wilde, J.I.1    Retzer, M.2    Siess, W.3    Watson, S.P.4
  • 74
    • 8344280956 scopus 로고    scopus 로고
    • The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented
    • P. Mangin, P. Ohlmann, A. Eckly, J.P. Cazenave, F. Lanza and C. Gachet (2004) The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented. J Thromb Haemost 2 969-977.
    • (2004) J Thromb Haemost , vol.2 , pp. 969-977
    • Mangin, P.1    Ohlmann, P.2    Eckly, A.3    Cazenave, J.P.4    Lanza, F.5    Gachet, C.6
  • 75
    • 0034672366 scopus 로고    scopus 로고
    • Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
    • K.J. Clemetson, J.M. Clemetson, A.E. Proudfoot, C.A. Power, M. Baggiolini and T.N. Wells (2000) Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Blood 96 4046-4054.
    • (2000) Blood , vol.96 , pp. 4046-4054
    • Clemetson, K.J.1    Clemetson, J.M.2    Proudfoot, A.E.3    Power, C.A.4    Baggiolini, M.5    Wells, T.N.6
  • 76
    • 0035830741 scopus 로고    scopus 로고
    • ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC
    • S. Suttitanamongkol and A.R. Gear (2001) ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC. FEBS Lett 490 84-87.
    • (2001) FEBS Lett , vol.490 , pp. 84-87
    • Suttitanamongkol, S.1    Gear, A.R.2
  • 77
    • 0037092952 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling
    • S. Kim, C. Foster, A. Lecchi, T.M. Quinton, D.M. Prosser, J. Jin, M. Cattaneo and S.P. Kunapuli (2002) Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling. Blood 99 3629-3636.
    • (2002) Blood , vol.99 , pp. 3629-3636
    • Kim, S.1    Foster, C.2    Lecchi, A.3    Quinton, T.M.4    Prosser, D.M.5    Jin, J.6    Cattaneo, M.7    Kunapuli, S.P.8
  • 78
    • 2942616511 scopus 로고    scopus 로고
    • Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin
    • P. Lova, F. Campus, R. Lombardi, M. Cattaneo, F. Sinigaglia, C. Balduini and M. Torti (2004) Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin. J Biol Chem 279 25299-25306.
    • (2004) J Biol Chem , vol.279 , pp. 25299-25306
    • Lova, P.1    Campus, F.2    Lombardi, R.3    Cattaneo, M.4    Sinigaglia, F.5    Balduini, C.6    Torti, M.7
  • 80
    • 79960971696 scopus 로고    scopus 로고
    • Effects of pharmacological inhibition of the P2Y1 and P2Y12 ADP receptors on shear-induced platelet aggregation and platelet thrombus formation on a collagen-coated surface under fl ow conditions
    • M. Cattaneo, B. Savage and Z.M. Ruggeri (2001) Effects of pharmacological inhibition of the P2Y1 and P2Y12 ADP receptors on shear-induced platelet aggregation and platelet thrombus formation on a collagen-coated surface under fl ow conditions. Blood 98 239a.
    • (2001) Blood , vol.98 , pp. 239a
    • Cattaneo, M.1    Savage, B.2    Ruggeri, Z.M.3
  • 81
    • 0035760304 scopus 로고    scopus 로고
    • Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under fl ow
    • N.A. Turner, J.L. Moake and L.V. McIntire (2001) Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under fl ow. Blood 98 3340-3345.
    • (2001) Blood , vol.98 , pp. 3340-3345
    • Turner, N.A.1    Moake, J.L.2    McIntire, L.V.3
  • 83
    • 3042825190 scopus 로고    scopus 로고
    • Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions
    • K. Takano, N. Asazuma, K. Satoh, Y. Yatomi and Y. Ozaki (2004) Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Platelets 15 223-229.
    • (2004) Platelets , vol.15 , pp. 223-229
    • Takano, K.1    Asazuma, N.2    Satoh, K.3    Yatomi, Y.4    Ozaki, Y.5
  • 84
    • 1542601104 scopus 로고    scopus 로고
    • Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity
    • C. Leon, C. Ravanat, M. Freund, J.P. Cazenave and C. Gachet (2003) Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity. Arterioscler Thromb Vasc Biol 23 1941-1947.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1941-1947
    • Leon, C.1    Ravanat, C.2    Freund, M.3    Cazenave, J.P.4    Gachet, C.5
  • 85
    • 13244264932 scopus 로고    scopus 로고
    • Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets
    • R.T. Dorsam, M. Tuluc and S.P. Kunapuli (2004) Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets. J Thromb Haemost 2 804-812.
    • (2004) J Thromb Haemost , vol.2 , pp. 804-812
    • Dorsam, R.T.1    Tuluc, M.2    Kunapuli, S.P.3
  • 86
    • 20444503923 scopus 로고    scopus 로고
    • Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk
    • P.E. van der Meijden, M.A. Feijge, P.L. Giesen, M. Huijberts, L.P. van Raak and J.W. Heemskerk (2005) Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thromb Haemost 93 1128-1136.
    • (2005) Thromb Haemost , vol.93 , pp. 1128-1136
    • van der Meijden, P.E.1    Feijge, M.A.2    Giesen, P.L.3    Huijberts, M.4    van Raak, L.P.5    Heemskerk, J.W.6
  • 87
    • 0035814760 scopus 로고    scopus 로고
    • Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: Studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist
    • C. Leon, M. Freund, C. Ravanat, A. Baurand, J.P. Cazenave and C. Gachet (2001) Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: Studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. Circulation 103 718-723.
    • (2001) Circulation , vol.103 , pp. 718-723
    • Leon, C.1    Freund, M.2    Ravanat, C.3    Baurand, A.4    Cazenave, J.P.5    Gachet, C.6
  • 90
    • 1542640443 scopus 로고    scopus 로고
    • Inhibition of localized thrombosis in P2Y1-defi cient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist
    • N. Lenain, M. Freund, C. Leon, J.P. Cazenave and C. Gachet (2003) Inhibition of localized thrombosis in P2Y1-defi cient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. J Thromb Haemost 1 1144-1149.
    • (2003) J Thromb Haemost , vol.1 , pp. 1144-1149
    • Lenain, N.1    Freund, M.2    Leon, C.3    Cazenave, J.P.4    Gachet, C.5
  • 91
    • 23044470109 scopus 로고    scopus 로고
    • The role of the P2Y1, P2Y12, and P2X1 platelet receptors in a laser induced model of arterial thrombosis in vivo
    • [abstract]
    • N. Lenain, M. Freund, B. Hechler, C. Léon, R. Evans, J.P. Cazenave and C. Gachet (2003) The role of the P2Y1, P2Y12, and P2X1 platelet receptors in a laser induced model of arterial thrombosis in vivo. J Thromb Haemost [abstract]
    • (2003) J Thromb Haemost
    • Lenain, N.1    Freund, M.2    Hechler, B.3    Léon, C.4    Evans, R.5    Cazenave, J.P.6    Gachet, C.7
  • 92
    • 0002251640 scopus 로고    scopus 로고
    • Congenital defi ciency of the phospholipase C coupled platelet P2Y1 receptor leads to a mild bleeding disorder
    • (Suppl), [abstract]
    • C. Oury, T. Lenaerts, K. Peerlinck, J. Vermylen and M.F. Hoylaerts (1999) Congenital defi ciency of the phospholipase C coupled platelet P2Y1 receptor leads to a mild bleeding disorder. (Suppl) Thromb Haemost 85 20. [abstract]
    • (1999) Thromb Haemost , vol.85 , pp. 20
    • Oury, C.1    Lenaerts, T.2    Peerlinck, K.3    Vermylen, J.4    Hoylaerts, M.F.5
  • 97
    • 1642320995 scopus 로고    scopus 로고
    • Nlinked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression
    • X. Zhong, R. Kriz, J. Seehra and R. Kumar (2004) Nlinked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression. FEBS Lett 562 111-117.
    • (2004) FEBS Lett , vol.562 , pp. 111-117
    • Zhong, X.1    Kriz, R.2    Seehra, J.3    Kumar, R.4
  • 100
    • 0037588974 scopus 로고    scopus 로고
    • Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270
    • Z. Ding, S. Kim, R.T. Dorsam, J. Jin and S.P. Kunapuli (2003) Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood 101 3908-3914.
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1    Kim, S.2    Dorsam, R.T.3    Jin, J.4    Kunapuli, S.P.5
  • 101
    • 13244258292 scopus 로고    scopus 로고
    • Adenine triphosphate nucleotides are antagonists at the P2Y receptor
    • G. Kauffenstein, B. Hechler, J.P. Cazenave and C. Gachet (2004) Adenine triphosphate nucleotides are antagonists at the P2Y receptor. J Thromb Haemost 2 1980-1988.
    • (2004) J Thromb Haemost , vol.2 , pp. 1980-1988
    • Kauffenstein, G.1    Hechler, B.2    Cazenave, J.P.3    Gachet, C.4
  • 105
    • 23844483596 scopus 로고    scopus 로고
    • Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation
    • T.M. Quinton, S. Kim, J. Jin and S.P. Kunapuli (2005) Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost 3 1036-1041.
    • (2005) J Thromb Haemost , vol.3 , pp. 1036-1041
    • Quinton, T.M.1    Kim, S.2    Jin, J.3    Kunapuli, S.P.4
  • 106
    • 0015870104 scopus 로고
    • Interactions of the pharmacological receptors of blood platelets with adenylate cyclase
    • R.J. Haslam (1973) Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol 6 333-350.
    • (1973) Ser Haematol , vol.6 , pp. 333-350
    • Haslam, R.J.1
  • 107
    • 0029893426 scopus 로고    scopus 로고
    • cAMP is not an important messenger for ADP-induced platelet aggregation
    • P. Savi, A.M. Pfl ieger A.M. and J.M. Herbert (1996) cAMP is not an important messenger for ADP-induced platelet aggregation. Blood Coagul Fibrinolysis 7 249-252.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 249-252
    • Savi, P.1    Pfl, A.M.2    Herbert, J.M.3
  • 108
    • 0344200064 scopus 로고    scopus 로고
    • Role of intracellular signaling events in ADP-induced platelet aggregation
    • J.L. Daniel, C. Dangelmaier, J. Jin, Y.B. Kim and S.P. Kunapuli (1999) Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb Haemost 82 1322-1326.
    • (1999) Thromb Haemost , vol.82 , pp. 1322-1326
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3    Kim, Y.B.4    Kunapuli, S.P.5
  • 109
    • 0037195456 scopus 로고    scopus 로고
    • Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors
    • J. Yang, J. Wu, H. Jiang, R. Mortensen, S. Austin, D.R. Manning, D. Woulfe and L.F. Brass (2002) Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem 277 46035-46042.
    • (2002) J Biol Chem , vol.277 , pp. 46035-46042
    • Yang, J.1    Wu, J.2    Jiang, H.3    Mortensen, R.4    Austin, S.5    Manning, D.R.6    Woulfe, D.7    Brass, L.F.8
  • 110
    • 0034668382 scopus 로고    scopus 로고
    • FcgammaRIIA requires a Gi-dependent pathway for an effi cient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation
    • M.P. Gratacap, J.P. Herault, C. Viala, A. Ragab, P. Savi, J.M. Herbert, H. Chap, M. Plantavid and B. Payrastre (2000) FcgammaRIIA requires a Gi-dependent pathway for an effi cient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation. Blood 96 3439-3446.
    • (2000) Blood , vol.96 , pp. 3439-3446
    • Gratacap, M.P.1    Herault, J.P.2    Viala, C.3    Ragab, A.4    Savi, P.5    Herbert, J.M.6    Chap, H.7    Plantavid, M.8    Payrastre, B.9
  • 111
    • 0034746160 scopus 로고    scopus 로고
    • Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway
    • C. Dangelmaier, J. Jin, J.B. Smith and S.P. Kunapuli (2001) Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway. Thromb Haemost 85 341-348.
    • (2001) Thromb Haemost , vol.85 , pp. 341-348
    • Dangelmaier, C.1    Jin, J.2    Smith, J.B.3    Kunapuli, S.P.4
  • 113
    • 2342486055 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases and the regulation of platelet function
    • S.P. Jackson, C.L. Yap and K.E. Anderson (2004) Phosphoinositide 3-kinases and the regulation of platelet function. Biochem Soc Trans 32 387-392.
    • (2004) Biochem Soc Trans , vol.32 , pp. 387-392
    • Jackson, S.P.1    Yap, C.L.2    Anderson, K.E.3
  • 114
    • 0033955027 scopus 로고    scopus 로고
    • ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors
    • G.E. Jarvis, R.G. Humphries, M.J. Robertson and P. Leff (2000) ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors. Br J Pharmacol 129 275-282.
    • (2000) Br J Pharmacol , vol.129 , pp. 275-282
    • Jarvis, G.E.1    Humphries, R.G.2    Robertson, M.J.3    Leff, P.4
  • 115
    • 0035860407 scopus 로고    scopus 로고
    • The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin — a phosphoinositide 3-kinase-dependent mechanism
    • G. Kauffenstein, W. Bergmeier, A. Eckly, P. Ohlmann, C. Leon, J.P. Cazenave, B. Nieswandt and C. Gachet (2001) The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin — a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett 505 281-290.
    • (2001) FEBS Lett , vol.505 , pp. 281-290
    • Kauffenstein, G.1    Bergmeier, W.2    Eckly, A.3    Ohlmann, P.4    Leon, C.5    Cazenave, J.P.6    Nieswandt, B.7    Gachet, C.8
  • 116
    • 1042301420 scopus 로고    scopus 로고
    • Akt activation in platelets depends on Gi signaling pathways
    • S. Kim, J. Jin and S.P. Kunapuli (2004) Akt activation in platelets depends on Gi signaling pathways. J Biol Chem 279 4186-4195.
    • (2004) J Biol Chem , vol.279 , pp. 4186-4195
    • Kim, S.1    Jin, J.2    Kunapuli, S.P.3
  • 117
    • 4444375609 scopus 로고    scopus 로고
    • Role of G proteingated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses
    • H. Shankar, S. Murugappan, S. Kim, J. Jin, Z. Ding, K. Wickman and S.P. Kunapuli (2004) Role of G proteingated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood 104 1335-1343.
    • (2004) Blood , vol.104 , pp. 1335-1343
    • Shankar, H.1    Murugappan, S.2    Kim, S.3    Jin, J.4    Ding, Z.5    Wickman, K.6    Kunapuli, S.P.7
  • 118
    • 0037189528 scopus 로고    scopus 로고
    • Activation of Rap1B by G(i) family members in platelets
    • D. Woulfe, H. Jiang, R. Mortensen, J. Yang and L.F. Brass (2002) Activation of Rap1B by G(i) family members in platelets. J Biol Chem 277 23382-23390.
    • (2002) J Biol Chem , vol.277 , pp. 23382-23390
    • Woulfe, D.1    Jiang, H.2    Mortensen, R.3    Yang, J.4    Brass, L.F.5
  • 119
    • 0037023134 scopus 로고    scopus 로고
    • A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets
    • P. Lova, S. Paganini, F. Sinigaglia, C. Balduini and M. Torti (2002) A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets. J Biol Chem 277 12009-12015.
    • (2002) J Biol Chem , vol.277 , pp. 12009-12015
    • Lova, P.1    Paganini, S.2    Sinigaglia, F.3    Balduini, C.4    Torti, M.5
  • 120
    • 0037441754 scopus 로고    scopus 로고
    • Identifi cation of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets
    • M.K. Larson, H. Chen, M.L. Kahn, A.M. Taylor, J.E. Fabre, R.M. Mortensen, P.B. Conley and L.V. Parise (2003) Identifi cation of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. Blood 101 1409-1415.
    • (2003) Blood , vol.101 , pp. 1409-1415
    • Larson, M.K.1    Chen, H.2    Kahn, M.L.3    Taylor, A.M.4    Fabre, J.E.5    Mortensen, R.M.6    Conley, P.B.7    Parise, L.V.8
  • 121
    • 0037414793 scopus 로고    scopus 로고
    • A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B
    • P. Lova, S. Paganini, E. Hirsch, L. Barberis, M. Wymann, F. Sinigaglia, C. Balduini and M. Torti (2003) A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B. J Biol Chem 278 131-138.
    • (2003) J Biol Chem , vol.278 , pp. 131-138
    • Lova, P.1    Paganini, S.2    Hirsch, E.3    Barberis, L.4    Wymann, M.5    Sinigaglia, F.6    Balduini, C.7    Torti, M.8
  • 123
    • 4444257333 scopus 로고    scopus 로고
    • Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets
    • A.R. Hardy, M.L. Jones, S.J. Mundell and A.W. Poole (2004) Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. Blood 104 1745-1752.
    • (2004) Blood , vol.104 , pp. 1745-1752
    • Hardy, A.R.1    Jones, M.L.2    Mundell, S.J.3    Poole, A.W.4
  • 124
    • 0033828411 scopus 로고    scopus 로고
    • The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets
    • S.O. Sage, E.H. Yamoah and J.W. Heemskerk (2008) The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets. Cell Calcium 28 119-126.
    • (2008) Cell Calcium , vol.28 , pp. 119-126
    • Sage, S.O.1    Yamoah, E.H.2    Heemskerk, J.W.3
  • 125
    • 34247605833 scopus 로고    scopus 로고
    • Concomitant activation of both the P2Y1-driven Gq and the P2Y12-driven Gi pathways is necessary for normal ADP-induced mobilization of cytoplasmic Ca2+
    • M. Cattaneo, A. Lecchi and R. Lombardi (2003) Concomitant activation of both the P2Y1-driven Gq and the P2Y12-driven Gi pathways is necessary for normal ADP-induced mobilization of cytoplasmic Ca2+. Hematol J 4 132.
    • (2003) Hematol J , vol.4 , pp. 132
    • Cattaneo, M.1    Lecchi, A.2    Lombardi, R.3
  • 126
    • 0347359012 scopus 로고    scopus 로고
    • Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists ARC69931MX and clopidogrel is enhanced by prostaglandin E1
    • S.C. Fox, M.W. Behan and S. Heptinstall (2004) Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists ARC69931MX and clopidogrel is enhanced by prostaglandin E1. Cell Calcium 35 39-46.
    • (2004) Cell Calcium , vol.35 , pp. 39-46
    • Fox, S.C.1    Behan, M.W.2    Heptinstall, S.3
  • 127
    • 0033760391 scopus 로고    scopus 로고
    • The central role of the P(2T) receptor in amplifi cation of human platelet activation, aggregation, secretion and procoagulant activity
    • R.F. Storey, H.M. Sanderson, A.E. White, J.A. May, K.E. Cameron and S. Heptinstall (2000) The central role of the P(2T) receptor in amplifi cation of human platelet activation, aggregation, secretion and procoagulant activity. Br J Haematol 110 925-934.
    • (2000) Br J Haematol , vol.110 , pp. 925-934
    • Storey, R.F.1    Sanderson, H.M.2    White, A.E.3    May, J.A.4    Cameron, K.E.5    Heptinstall, S.6
  • 128
    • 0037324241 scopus 로고    scopus 로고
    • Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets
    • I.A. Jagroop, G. Burnstock and D.P. Mikhailidis (2003) Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets. Platelets 14 15-20.
    • (2003) Platelets , vol.14 , pp. 15-20
    • Jagroop, I.A.1    Burnstock, G.2    Mikhailidis, D.P.3
  • 129
    • 0036344708 scopus 로고    scopus 로고
    • Effects of P2Y(1) and P2Y(12) receptor antagonists on ADPinduced shape change of equine platelets: Comparison with human platelets
    • G. Mateos-Trigos, R.J. Evans and M.F. Heath (2002) Effects of P2Y(1) and P2Y(12) receptor antagonists on ADPinduced shape change of equine platelets: Comparison with human platelets. Platelets 13 285-292.
    • (2002) Platelets , vol.13 , pp. 285-292
    • Mateos-Trigos, G.1    Evans, R.J.2    Heath, M.F.3
  • 130
    • 0030610096 scopus 로고    scopus 로고
    • Defi ciency of [33P]2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production
    • M. Cattaneo, R. Lombardi, M.L. Zighetti, C. Gachet, P. Ohlmann, J.P. Cazenave and P.M. Mannucci (1997) Defi ciency of [33P]2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production. Thromb Haemost 77 986-990.
    • (1997) Thromb Haemost , vol.77 , pp. 986-990
    • Cattaneo, M.1    Lombardi, R.2    Zighetti, M.L.3    Gachet, C.4    Ohlmann, P.5    Cazenave, J.P.6    Mannucci, P.M.7
  • 131
    • 0034323126 scopus 로고    scopus 로고
    • Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet “primary secretion defect” are heterozygous for a defect of P2CYC receptors
    • M. Cattaneo, A. Lecchi, R. Lombardi, C. Gachet and M.L. Zighetti (2000) Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet “primary secretion defect” are heterozygous for a defect of P2CYC receptors. Arterioscler Thromb Vasc Biol 20 E101-E106.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. E101-E106
    • Cattaneo, M.1    Lecchi, A.2    Lombardi, R.3    Gachet, C.4    Zighetti, M.L.5
  • 132
    • 0004979209 scopus 로고    scopus 로고
    • ADP potentiates platelet dense granule secretion induced by U46619 or TRAP through its interaction with the P2cyc receptor
    • A. Lecchi, M. Cattaneo and P.M. Mannucci (2000) ADP potentiates platelet dense granule secretion induced by U46619 or TRAP through its interaction with the P2cyc receptor. Haematologica 85(Suppl5), 83.
    • (2000) Haematologica , vol.85 , pp. 83
    • Lecchi, A.1    Cattaneo, M.2    Mannucci, P.M.3
  • 133
    • 0042733338 scopus 로고    scopus 로고
    • Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases
    • Z. Li, G. Zhang, G.C. Le Breton, X. Gao, A.B. Malik and X. Du (2003) Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem 278 30725-30731.
    • (2003) J Biol Chem , vol.278 , pp. 30725-30731
    • Li, Z.1    Zhang, G.2    Le Breton, G.C.3    Gao, X.4    Malik, A.B.5    Du, X.6
  • 134
    • 0034745014 scopus 로고    scopus 로고
    • Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation
    • A. Eckly, J.L. Gendrault, B. Hechler, J.P. Cazenave and C. Gachet (2001) Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation. Thromb Haemost 85 694-701.
    • (2001) Thromb Haemost , vol.85 , pp. 694-701
    • Eckly, A.1    Gendrault, J.L.2    Hechler, B.3    Cazenave, J.P.4    Gachet, C.5
  • 136
    • 0028942659 scopus 로고
    • An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its infl uence on glycoprotein IIb-IIIa complex function
    • P. Nurden, P. Savi, E. Heilmann, C. Bihour, J.M. Herbert, J.P. Maffrand and A. Nurden (1995) An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its infl uence on glycoprotein IIb-IIIa complex function. J Clin Invest 95 1612-1622.
    • (1995) J Clin Invest , vol.95 , pp. 1612-1622
    • Nurden, P.1    Savi, P.2    Heilmann, E.3    Bihour, C.4    Herbert, J.M.5    Maffrand, J.P.6    Nurden, A.7
  • 137
    • 0037032558 scopus 로고    scopus 로고
    • Coordinated signaling through both G12/13 and G(i) pathways is suffi cient to activate GPIIb/IIIa in human platelets
    • R.T. Dorsam, S. Kim, J. Jin and S.P. Kunapuli (2002) Coordinated signaling through both G12/13 and G(i) pathways is suffi cient to activate GPIIb/IIIa in human platelets. J Biol Chem 277 47588-47595.
    • (2002) J Biol Chem , vol.277 , pp. 47588-47595
    • Dorsam, R.T.1    Kim, S.2    Jin, J.3    Kunapuli, S.P.4
  • 138
    • 0037130959 scopus 로고    scopus 로고
    • Costimulation of Gi-and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets
    • B. Nieswandt, V. Schulte, A. Zywietz, M.P. Gratacap and S. Offermanns (2002) Costimulation of Gi-and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem 277 39493-39498.
    • (2002) J Biol Chem , vol.277 , pp. 39493-39498
    • Nieswandt, B.1    Schulte, V.2    Zywietz, A.3    Gratacap, M.P.4    Offermanns, S.5
  • 139
    • 1642400249 scopus 로고    scopus 로고
    • The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: Involvement of P2Y1 and P2Y12 receptors
    • N. Haseruck, W. Erl, D. Pandey, G. Tigyi, P. Ohlmann, C. Ravanat, C. Gachet and W. Siess (2004) The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: Involvement of P2Y1 and P2Y12 receptors. Blood 103 2585-2592.
    • (2004) Blood , vol.103 , pp. 2585-2592
    • Haseruck, N.1    Erl, W.2    Pandey, D.3    Tigyi, G.4    Ohlmann, P.5    Ravanat, C.6    Gachet, C.7    Siess, W.8
  • 140
    • 0029883665 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affi nity Fc gamma receptor on human platelets through an immunoreceptor tyrosinebased activation motif. Reconstitution with synthetic phosphopeptides
    • G.W. Chacko, J.T. Brandt, K.M. Coggeshall and C.L. Anderson (1996) Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affi nity Fc gamma receptor on human platelets through an immunoreceptor tyrosinebased activation motif. Reconstitution with synthetic phosphopeptides. J Biol Chem 271 10775-10781.
    • (1996) J Biol Chem , vol.271 , pp. 10775-10781
    • Chacko, G.W.1    Brandt, J.T.2    Coggeshall, K.M.3    Anderson, C.L.4
  • 141
    • 0032544546 scopus 로고    scopus 로고
    • Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets
    • M.P. Gratacap, B. Payrastre, C. Viala, G. Mauco, M. Plantavid and H. Chap (1998) Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem 273 24314-24321.
    • (1998) J Biol Chem , vol.273 , pp. 24314-24321
    • Gratacap, M.P.1    Payrastre, B.2    Viala, C.3    Mauco, G.4    Plantavid, M.5    Chap, H.6
  • 142
    • 0031963059 scopus 로고    scopus 로고
    • Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by sera from heparin-induced thrombocytopenia patients
    • J. Polgar, P. Eichler, A. Greinacher and K.J. Clemetson (1998) Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by sera from heparin-induced thrombocytopenia patients. Blood 91 549-554.
    • (1998) Blood , vol.91 , pp. 549-554
    • Polgar, J.1    Eichler, P.2    Greinacher, A.3    Clemetson, K.J.4
  • 143
    • 0033593215 scopus 로고    scopus 로고
    • Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl)
    • A. Saci, S. Pain, F. Rendu and C. Bachelot-Loza (1999) Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl). J Biol Chem 274 1898-1904.
    • (1999) J Biol Chem , vol.274 , pp. 1898-1904
    • Saci, A.1    Pain, S.2    Rendu, F.3    Bachelot-Loza, C.4
  • 145
    • 0032828089 scopus 로고    scopus 로고
    • Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors
    • B.Z. Paul, J. Jin and S.P. Kunapuli (1999) Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem 274 29108-29114.
    • (1999) J Biol Chem , vol.274 , pp. 29108-29114
    • Paul, B.Z.1    Jin, J.2    Kunapuli, S.P.3
  • 146
    • 0031757535 scopus 로고    scopus 로고
    • Abnormal tyrosine phosphorylation linked to a defective interaction between ADP and its receptor on platelets
    • S. Levy-Toledano, J. Maclouf, J.P. Rosa, C. Gallet, G. Valles, P. Nurden and A.T. Nurden (1998) Abnormal tyrosine phosphorylation linked to a defective interaction between ADP and its receptor on platelets. Thromb Haemost 80 463-468.
    • (1998) Thromb Haemost , vol.80 , pp. 463-468
    • Levy-Toledano, S.1    Maclouf, J.2    Rosa, J.P.3    Gallet, C.4    Valles, G.5    Nurden, P.6    Nurden, A.T.7
  • 147
    • 18844376377 scopus 로고    scopus 로고
    • P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets
    • K. Falker, D. Lange and P. Presek (2005) P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets. Thromb Haemost 93 880-888.
    • (2005) Thromb Haemost , vol.93 , pp. 880-888
    • Falker, K.1    Lange, D.2    Presek, P.3
  • 148
    • 3543031018 scopus 로고    scopus 로고
    • ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets
    • K. Falker, D. Lange and P. Presek (2004) ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets. Thromb Haemost 92 114-123.
    • (2004) Thromb Haemost , vol.92 , pp. 114-123
    • Falker, K.1    Lange, D.2    Presek, P.3
  • 149
    • 0347985760 scopus 로고    scopus 로고
    • Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation
    • S. Roger, M. Pawlowski, A. Habib, M. Jandrot-Perrus, J.P. Rosa and M. Bryckaert (2004) Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation. FEBS Lett 556 227-235.
    • (2004) FEBS Lett , vol.556 , pp. 227-235
    • Roger, S.1    Pawlowski, M.2    Habib, A.3    Jandrot-Perrus, M.4    Rosa, J.P.5    Bryckaert, M.6
  • 150
    • 0027449969 scopus 로고
    • Shear-induced platelet aggregation is potentiated by desmopressin (DDAVP) and inhibited by ticlopidine
    • M. Cattaneo, R. Lombardi, D. Bettega, A. Lecchi and P.M. Mannucci (1993) Shear-induced platelet aggregation is potentiated by desmopressin (DDAVP) and inhibited by ticlopidine. Arterioscl Thromb 13 393.
    • (1993) Arterioscl Thromb , vol.13 , pp. 393
    • Cattaneo, M.1    Lombardi, R.2    Bettega, D.3    Lecchi, A.4    Mannucci, P.M.5
  • 151
    • 0028090198 scopus 로고
    • Role of ADP in platelet aggregation at high shear: Studies in a patient with congenital defect of platelet responses to ADP
    • M. Cattaneo, M.L. Zighetti, R. Lombardi and P.M. Mannucci (1994) Role of ADP in platelet aggregation at high shear: Studies in a patient with congenital defect of platelet responses to ADP. Br J Haematol 88 826-829.
    • (1994) Br J Haematol , vol.88 , pp. 826-829
    • Cattaneo, M.1    Zighetti, M.L.2    Lombardi, R.3    Mannucci, P.M.4
  • 152
    • 0037188563 scopus 로고    scopus 로고
    • Functional signifi cance of adenosine 5.-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate
    • S. Goto, N. Tamura, K. Eto, Y. Ikeda and S. Handa (2002) Functional signifi cance of adenosine 5.-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate. Circulation 105 2531-2536.
    • (2002) Circulation , vol.105 , pp. 2531-2536
    • Goto, S.1    Tamura, N.2    Eto, K.3    Ikeda, Y.4    Handa, S.5
  • 153
    • 0035185949 scopus 로고    scopus 로고
    • Effects of ticlopidine on von Willebrand factormediated shear-induced platelet activation and aggregation
    • S. Goto, N. Tamura, M. Sakakibara, Y. Ikeda and S. Handa (2001) Effects of ticlopidine on von Willebrand factormediated shear-induced platelet activation and aggregation. Platelets 12 406-414.
    • (2001) Platelets , vol.12 , pp. 406-414
    • Goto, S.1    Tamura, N.2    Sakakibara, M.3    Ikeda, Y.4    Handa, S.5
  • 154
    • 0037333465 scopus 로고    scopus 로고
    • Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation
    • J.C. Resendiz, S. Feng, G. Ji, K.A. Francis, M.C. Berndt and M.H. Kroll (2003) Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation. Mol Pharmacol 63 639-645.
    • (2003) Mol Pharmacol , vol.63 , pp. 639-645
    • Resendiz, J.C.1    Feng, S.2    Ji, G.3    Francis, K.A.4    Berndt, M.C.5    Kroll, M.H.6
  • 155
    • 0036714323 scopus 로고    scopus 로고
    • Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin
    • R.F. Storey, H.M. Judge, R.G. Wilcox and S. Heptinstall (2002) Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thromb Haemost 88 488-494.
    • (2002) Thromb Haemost , vol.88 , pp. 488-494
    • Storey, R.F.1    Judge, H.M.2    Wilcox, R.G.3    Heptinstall, S.4
  • 156
    • 0027255815 scopus 로고
    • Experimental thrombosis on a collage coated arterioarterial shunt in rats: A pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition
    • M. Freund, F. Mantz, P. Nicolini, C. Gachet, J. Mulvihill, L. Meyer, A. Beretz and J.P. Cazenave (1993) Experimental thrombosis on a collage coated arterioarterial shunt in rats: A pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition. Thromb Haemost 69 515-521.
    • (1993) Thromb Haemost , vol.69 , pp. 515-521
    • Freund, M.1    Mantz, F.2    Nicolini, P.3    Gachet, C.4    Mulvihill, J.5    Meyer, L.6    Beretz, A.7    Cazenave, J.P.8
  • 157
    • 0027486705 scopus 로고
    • Combined ADP and thromboxane A2 antagonism prevents cyclic fl ow variations in stenosed and endothelium-injured arteries in nonhuman primates
    • S.K. Yao, J. McNatt, K. Cui, H.V. Anderson, J.P. Maffrand, L.M. Buja and J.T. Willerson (1993) Combined ADP and thromboxane A2 antagonism prevents cyclic fl ow variations in stenosed and endothelium-injured arteries in nonhuman primates. Circulation 88 2888-2893.
    • (1993) Circulation , vol.88 , pp. 2888-2893
    • Yao, S.K.1    McNatt, J.2    Cui, K.3    Anderson, H.V.4    Maffrand, J.P.5    Buja, L.M.6    Willerson, J.T.7
  • 158
    • 0028015993 scopus 로고
    • Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis
    • S.K. Yao, J.C. Ober, J.J. Ferguson, J.P. Maffrand, H.V. Anderson, L.M. Buja and J.T. Willerson (1994) Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis. Am J Physiol 267 H488-H493.
    • (1994) Am J Physiol , vol.267 , pp. H488-H493
    • Yao, S.K.1    Ober, J.C.2    Ferguson, J.J.3    Maffrand, J.P.4    Anderson, H.V.5    Buja, L.M.6    Willerson, J.T.7
  • 159
    • 0026601274 scopus 로고
    • ADP plays an important role in mediating platelet aggregation and cyclic fl ow variations in vivo in stenosed and endothelium-injured canine coronary arteries
    • S.K. Yao, J.C. Ober, J. McNatt, C.R. Benedict, M. Rosolowsky, H.V. Anderson, K. Cui, J.P. Maffrand, W.B. Campbell, L.M. Buja, et al. (1992) ADP plays an important role in mediating platelet aggregation and cyclic fl ow variations in vivo in stenosed and endothelium-injured canine coronary arteries. Circ Res 70 39-48.
    • (1992) Circ Res , vol.70 , pp. 39-48
    • Yao, S.K.1    Ober, J.C.2    McNatt, J.3    Benedict, C.R.4    Rosolowsky, M.5    Anderson, H.V.6    Cui, K.7    Maffrand, J.P.8    Campbell, W.B.9    Buja, L.M.10
  • 160
    • 0026806029 scopus 로고
    • Importance of platelets in experimental venous thrombosis in the rat
    • J.M. Herbert, A. Bernat and J.P. Maffrand (1992) Importance of platelets in experimental venous thrombosis in the rat. Blood 80 2281-2286.
    • (1992) Blood , vol.80 , pp. 2281-2286
    • Herbert, J.M.1    Bernat, A.2    Maffrand, J.P.3
  • 161
    • 0027450592 scopus 로고
    • Potentiating effect of clopidogrel and SR 46349, a novel 5-HT2 antagonist, on streptokinaseinduced thrombolysis in the rabbit
    • J.M. Herbert, A. Bernat, M. Sainte-Marie, F. Dol and M. Rinaldi (1993) Potentiating effect of clopidogrel and SR 46349, a novel 5-HT2 antagonist, on streptokinaseinduced thrombolysis in the rabbit. Thromb Haemost 69 268-271.
    • (1993) Thromb Haemost , vol.69 , pp. 268-271
    • Herbert, J.M.1    Bernat, A.2    Sainte-Marie, M.3    Dol, F.4    Rinaldi, M.5
  • 163
    • 0033781969 scopus 로고    scopus 로고
    • Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model
    • J. Huang, E.M. Driscoll, M.L. Gonzales, A.M. Park and B.R. Lucchesi (2000) Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J Pharmacol Exp Ther 295 492-499.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 492-499
    • Huang, J.1    Driscoll, E.M.2    Gonzales, M.L.3    Park, A.M.4    Lucchesi, B.R.5
  • 164
    • 0028981512 scopus 로고
    • Pharmacological profi le of the novel P2T-purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo
    • R.G. Humphries, W. Tomlinson, J.A. Clegg, A.H. Ingall, N.D. Kindon and P. Leff (1995) Pharmacological profi le of the novel P2T-purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo. Br J Pharmacol 115 1110-1116.
    • (1995) Br J Pharmacol , vol.115 , pp. 1110-1116
    • Humphries, R.G.1    Tomlinson, W.2    Clegg, J.A.3    Ingall, A.H.4    Kindon, N.D.5    Leff, P.6
  • 167
    • 0037981343 scopus 로고    scopus 로고
    • ADP receptor antagonists as antiplatelet therapeutics
    • S.M. Bauer (2003) ADP receptor antagonists as antiplatelet therapeutics. Expert Opin Emerg Drugs 8 93-101.
    • (2003) Expert Opin Emerg Drugs , vol.8 , pp. 93-101
    • Bauer, S.M.1
  • 168
    • 27444447117 scopus 로고    scopus 로고
    • The platelet P2 receptors as molecular targets for old and new antiplatelet drugs
    • C. Gachet (2005) The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Therapeut 108 180-192.
    • (2005) Pharmacol Therapeut , vol.108 , pp. 180-192
    • Gachet, C.1
  • 169
    • 18044381917 scopus 로고    scopus 로고
    • The platelet P2 receptors in thrombosis
    • C. Gachet and B. Hechler (2005) The platelet P2 receptors in thrombosis. Semin Thromb Hemost 31 162-167.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 162-167
    • Gachet, C.1    Hechler, B.2
  • 170
    • 79960971649 scopus 로고    scopus 로고
    • Unique mutations in the P2Y12 locus of patients with previously described defects in ADPdependent aggregation
    • P.B. Conley, M.M. Jurek, D. Vincent, A. Lecchi and M. Cattaneo (2001) Unique mutations in the P2Y12 locus of patients with previously described defects in ADPdependent aggregation. Blood 98 43b.
    • (2001) Blood , vol.98 , pp. 43b
    • Conley, P.B.1    Jurek, M.M.2    Vincent, D.3    Lecchi, A.4    Cattaneo, M.5
  • 171
    • 28444439191 scopus 로고    scopus 로고
    • Impaired platelet function in a patient with P2Y12 defi ciency caused by a mutation in the translation initiation codon
    • M. Shiraga, S. Miyata, H. Kato, H. Kashiwagi, S. Honda, Y. Kurata, Y. Tomiyama and Y. Kanakura (2005) Impaired platelet function in a patient with P2Y12 defi ciency caused by a mutation in the translation initiation codon. J Thromb Haemost 3 2315-2323.
    • (2005) J Thromb Haemost , vol.3 , pp. 2315-2323
    • Shiraga, M.1    Miyata, S.2    Kato, H.3    Kashiwagi, H.4    Honda, S.5    Kurata, Y.6    Tomiyama, Y.7    Kanakura, Y.8
  • 172
    • 0141609789 scopus 로고    scopus 로고
    • Inherited platelet-based bleeding disorders
    • M. Cattaneo (2003) Inherited platelet-based bleeding disorders. J Thromb Haemost 1 1628-1636.
    • (2003) J Thromb Haemost , vol.1 , pp. 1628-1636
    • Cattaneo, M.1
  • 173
    • 0033596870 scopus 로고    scopus 로고
    • Role of the extracellular loops of G protein-coupled receptors in ligand recognition: A molecular modeling study of the human P2Y1 receptor
    • S. Moro, C. Hoffmann and K.A. Jacobson (1998) Role of the extracellular loops of G protein-coupled receptors in ligand recognition: A molecular modeling study of the human P2Y1 receptor. Biochemistry 38 3498-3507.
    • (1998) Biochemistry , vol.38 , pp. 3498-3507
    • Moro, S.1    Hoffmann, C.2    Jacobson, K.A.3
  • 174
    • 0032559887 scopus 로고    scopus 로고
    • Human P2Y1 receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites
    • S. Moro, D. Guo, E. Camaioni, J.L. Boyer, T.K. Harden and K.A. Jacobson (1998) Human P2Y1 receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem 41 1456-1466.
    • (1998) J Med Chem , vol.41 , pp. 1456-1466
    • Moro, S.1    Guo, D.2    Camaioni, E.3    Boyer, J.L.4    Harden, T.K.5    Jacobson, K.A.6
  • 175
    • 0032873146 scopus 로고    scopus 로고
    • Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets — defi nition and detection of ticlopidine/clopidogrel effects
    • U.R. Schwarz, J. Geiger, U. Walter and M. Eigenthaler (1999) Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets — defi nition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 82 1145-1152.
    • (1999) Thromb Haemost , vol.82 , pp. 1145-1152
    • Schwarz, U.R.1    Geiger, J.2    Walter, U.3    Eigenthaler, M.4
  • 176
    • 0042859862 scopus 로고    scopus 로고
    • Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
    • P. Fontana, A. Dupont, S. Gandrille, C. Bachelot-Loza, J.L. Reny, M. Aiach and P. Gaussem (2003) Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 108 989-995.
    • (2003) Circulation , vol.108 , pp. 989-995
    • Fontana, P.1    Dupont, A.2    Gandrille, S.3    Bachelot-Loza, C.4    Reny, J.L.5    Aiach, M.6    Gaussem, P.7
  • 177
    • 0346365089 scopus 로고    scopus 로고
    • P2Y12 H2 haplotype is associated with peripheral arterial disease: A case-control study
    • P. Fontana, P. Gaussem, M. Aiach, J.N. Fiessinger, J. Emmerich and J.L. Reny (2003) P2Y12 H2 haplotype is associated with peripheral arterial disease: A case-control study. Circulation 108 2971-2973.
    • (2003) Circulation , vol.108 , pp. 2971-2973
    • Fontana, P.1    Gaussem, P.2    Aiach, M.3    Fiessinger, J.N.4    Emmerich, J.5    Reny, J.L.6
  • 178
    • 17444429227 scopus 로고    scopus 로고
    • P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphateinduced platelet aggregation after initiation of clopidogrel therapy with a high loading dose
    • N. von Beckerath, O. von Beckerath, W. Koch, M. Eichinger, A. Schomig and A. Kastrati (2005) P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphateinduced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 16 199-204.
    • (2005) Blood Coagul Fibrinolysis , vol.16 , pp. 199-204
    • von Beckerath, N.1    von Beckerath, O.2    Koch, W.3    Eichinger, M.4    Schomig, A.5    Kastrati, A.6
  • 179
    • 0030059479 scopus 로고    scopus 로고
    • Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets
    • A.B. MacKenzie, M.P. Mahaut-Smith and S.O. Sage (1996) Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets. J Biol Chem 271 2879-2881.
    • (1996) J Biol Chem , vol.271 , pp. 2879-2881
    • MacKenzie, A.B.1    Mahaut-Smith, M.P.2    Sage, S.O.3
  • 180
    • 0030608644 scopus 로고    scopus 로고
    • Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines
    • C. Vial, B. Hechler, C. Leon, J.P. Cazenave and C. Gachet (1997) Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines. Thromb Haemost 78 1500-1584.
    • (1997) Thromb Haemost , vol.78 , pp. 1500-1584
    • Vial, C.1    Hechler, B.2    Leon, C.3    Cazenave, J.P.4    Gachet, C.5
  • 181
    • 0032056369 scopus 로고    scopus 로고
    • The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes
    • E.E. Clifford, K. Parker, B.D. Humphreys, S.B. Kertesy and G.R. Dubyak (1998) The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. Blood 91 3172-3181.
    • (1998) Blood , vol.91 , pp. 3172-3181
    • Clifford, E.E.1    Parker, K.2    Humphreys, B.D.3    Kertesy, S.B.4    Dubyak, G.R.5
  • 183
    • 0032495873 scopus 로고    scopus 로고
    • P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression
    • B. Sun, J. Li, K. Okahara and J. Kambayashi (1998) P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. J Biol Chem 273 11544-11547.
    • (1998) J Biol Chem , vol.273 , pp. 11544-11547
    • Sun, B.1    Li, J.2    Okahara, K.3    Kambayashi, J.4
  • 184
    • 0033057619 scopus 로고    scopus 로고
    • No requirement of P2X1 purinoceptors for platelet aggregation
    • S. Takano, J. Kimura, I. Matsuoka and T. Ono (1999) No requirement of P2X1 purinoceptors for platelet aggregation. Eur J Pharmacol 372 305-309.
    • (1999) Eur J Pharmacol , vol.372 , pp. 305-309
    • Takano, S.1    Kimura, J.2    Matsuoka, I.3    Ono, T.4
  • 185
    • 0030873933 scopus 로고    scopus 로고
    • Characterization of P2X1 purinoreceptors on rat platelets: Effect of clopidogrel
    • P. Savi, J. Bornia, V. Salel, M. Delfaud and J.M. Herbert (1997) Characterization of P2X1 purinoreceptors on rat platelets: Effect of clopidogrel. Br J Haematol 98 880-886.
    • (1997) Br J Haematol , vol.98 , pp. 880-886
    • Savi, P.1    Bornia, J.2    Salel, V.3    Delfaud, M.4    Herbert, J.M.5
  • 186
    • 0033821625 scopus 로고    scopus 로고
    • ADP is not an agonist at P2X(1) receptors: Evidence for separate receptors stimulated by ATP and ADP on human platelets
    • M.P. Mahaut-Smith, S.J. Ennion, M.G. Rolf and R.J. Evans (2000) ADP is not an agonist at P2X(1) receptors: Evidence for separate receptors stimulated by ATP and ADP on human platelets. Br J Pharmacol 131 108-114.
    • (2000) Br J Pharmacol , vol.131 , pp. 108-114
    • Mahaut-Smith, M.P.1    Ennion, S.J.2    Rolf, M.G.3    Evans, R.J.4
  • 187
    • 0035412397 scopus 로고    scopus 로고
    • Novel structurally altered P(2X1) receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells
    • N.J. Greco, G. Tonon, W. Chen, X. Luo, R. Dalal and G.A. Jamieson (2001) Novel structurally altered P(2X1) receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells. Blood 98 100-107.
    • (2001) Blood , vol.98 , pp. 100-107
    • Greco, N.J.1    Tonon, G.2    Chen, W.3    Luo, X.4    Dalal, R.5    Jamieson, G.A.6
  • 188
    • 0242494876 scopus 로고    scopus 로고
    • Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis
    • C. Vial, S.J. Pitt, J. Roberts, M.G. Rolf, M.P. Mahaut-Smith and R.J. Evans (2003) Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis. Blood 102 3646-3651.
    • (2003) Blood , vol.102 , pp. 3646-3651
    • Vial, C.1    Pitt, S.J.2    Roberts, J.3    Rolf, M.G.4    Mahaut-Smith, M.P.5    Evans, R.J.6
  • 189
    • 0036713665 scopus 로고    scopus 로고
    • Effects of enhanced P2X1 receptor Ca2+ infl ux on functional responses in human platelets
    • M.G. Rolf and M.P. Mahaut-Smith (2002) Effects of enhanced P2X1 receptor Ca2+ infl ux on functional responses in human platelets. Thromb Haemost 88 495-502.
    • (2002) Thromb Haemost , vol.88 , pp. 495-502
    • Rolf, M.G.1    Mahaut-Smith, M.P.2
  • 190
    • 0345306665 scopus 로고    scopus 로고
    • P2X1-mediated ERK2 activation amplifi es the collagen-induced platelet secretion by enhancing myosin light chain kinase activation
    • E. Toth-Zsamboki, C. Oury, H. Cornelissen, R. De Vos, J. Vermylen and M.F. Hoylaerts (2003) P2X1-mediated ERK2 activation amplifi es the collagen-induced platelet secretion by enhancing myosin light chain kinase activation. J Biol Chem 278 46661-46667.
    • (2003) J Biol Chem , vol.278 , pp. 46661-46667
    • Toth-Zsamboki, E.1    Oury, C.2    Cornelissen, H.3    De Vos, R.4    Vermylen, J.5    Hoylaerts, M.F.6
  • 191
    • 0036786354 scopus 로고    scopus 로고
    • P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen
    • C. Oury, E. Toth-Zsamboki, J. Vermylen and M.F. Hoylaerts (2002) P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen. Blood 100 2499-2505.
    • (2002) Blood , vol.100 , pp. 2499-2505
    • Oury, C.1    Toth-Zsamboki, E.2    Vermylen, J.3    Hoylaerts, M.F.4
  • 194
    • 1542544887 scopus 로고    scopus 로고
    • Potentiation of platelet activation through the stimulation of P2X1 receptors
    • J.A. Erhardt, K. Pillarisetti and J.R. Toomey (2003) Potentiation of platelet activation through the stimulation of P2X1 receptors. J Thromb Haemost 1 2626-2635.
    • (2003) J Thromb Haemost , vol.1 , pp. 2626-2635
    • Erhardt, J.A.1    Pillarisetti, K.2    Toomey, J.R.3
  • 195
    • 0242492279 scopus 로고    scopus 로고
    • Thrombopoietin enhances rapid current responses mediated by P2X1 receptors on megakaryocytic cells in culture
    • K. Kawa (2003) Thrombopoietin enhances rapid current responses mediated by P2X1 receptors on megakaryocytic cells in culture. Jpn J Physiol 53 287-299.
    • (2003) Jpn J Physiol , vol.53 , pp. 287-299
    • Kawa, K.1
  • 196
    • 22144441729 scopus 로고    scopus 로고
    • A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets
    • C.Y. Fung, C.A. Brearley, R.W. Farndale and M.P. MahautSmith (2005) A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets. Thromb Haemost 94 37-40.
    • (2005) Thromb Haemost , vol.94 , pp. 37-40
    • Fung, C.Y.1    Brearley, C.A.2    Farndale, R.W.3    MahautSmith, M.P.4
  • 197
    • 0036008197 scopus 로고    scopus 로고
    • A study of P2X(1) receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors
    • C. Vial, M.G. Rolf, M.P. Mahaut-Smith and R.J. Evans (2002) A study of P2X(1) receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors. Br J Pharmacol 135 363-372.
    • (2002) Br J Pharmacol , vol.135 , pp. 363-372
    • Vial, C.1    Rolf, M.G.2    Mahaut-Smith, M.P.3    Evans, R.J.4
  • 200
    • 1842557492 scopus 로고    scopus 로고
    • Structure-activity relationships of analogues of NF449 confi rm NF449 as the most potent and selective known P2X1 receptor antagonist
    • M.U. Kassack, K. Braun, M. Ganso, H. Ullmann, P. Nickel, B. Boing, G. Muller and G. Lambrecht (2004) Structure-activity relationships of analogues of NF449 confi rm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur J Med Chem 39 345-357.
    • (2004) Eur J Med Chem , vol.39 , pp. 345-357
    • Kassack, M.U.1    Braun, K.2    Ganso, M.3    Ullmann, H.4    Nickel, P.5    Boing, B.6    Muller, G.7    Lambrecht, G.8
  • 201
    • 23044488487 scopus 로고    scopus 로고
    • Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4.,4.,4.-(carbonylbis(imino-5,1,3-benzenet r iylbis (carbonylimino)))tetraki s-benzene-1,3-disulfonic acid octasodium salt]
    • B. Hechler, S. Magnenat, M.L. Zighetti, M.U. Kassack, H. Ullmann, J.P. Cazenave, R. Evans, M. Cattaneo and C. Gachet (2005) Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4.,4.,4.-(carbonylbis(imino-5,1,3-benzenet r iylbis (carbonylimino)))tetraki s-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther 314 232-243.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 232-243
    • Hechler, B.1    Magnenat, S.2    Zighetti, M.L.3    Kassack, M.U.4    Ullmann, H.5    Cazenave, J.P.6    Evans, R.7    Cattaneo, M.8    Gachet, C.9
  • 203
    • 0034725571 scopus 로고    scopus 로고
    • A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue
    • C. Oury, E. Toth-Zsamboki, C. Van Geet, C. Thys, L. Wei, B. Nilius, et al. (2000) A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue. J Biol Chem 275 22611-22614.
    • (2000) J Biol Chem , vol.275 , pp. 22611-22614
    • Oury, C.1    Toth-Zsamboki, E.2    Van Geet, C.3    Thys, C.4    Wei, L.5    Nilius, B.6
  • 204
    • 23944488822 scopus 로고    scopus 로고
    • Interplay between P2Y, P2Y, and P2X(1) receptors in the activation of mega karyocyte cation infl ux currents by ADP: Evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling
    • G. Tolhurst, C. Vial, C. Leon, C. Gachet, R.J. Evans and M.P. Mahaut-Smith (2005) Interplay between P2Y, P2Y, and P2X(1) receptors in the activation of mega karyocyte cation infl ux currents by ADP: Evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood 106 1644-1651.
    • (2005) Blood , vol.106 , pp. 1644-1651
    • Tolhurst, G.1    Vial, C.2    Leon, C.3    Gachet, C.4    Evans, R.J.5    Mahaut-Smith, M.P.6
  • 205
    • 18244389451 scopus 로고    scopus 로고
    • P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
    • A.R. Hardy, P.B. Conley, J. Luo, J.L. Benovic, A.W. Poole and S.J. Mundell (2005) P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood 105 3552-3560.
    • (2005) Blood , vol.105 , pp. 3552-3560
    • Hardy, A.R.1    Conley, P.B.2    Luo, J.3    Benovic, J.L.4    Poole, A.W.5    Mundell, S.J.6
  • 207
    • 18044388905 scopus 로고    scopus 로고
    • Preclinical and clinical studies with selective reversible direct P2Y12 antagonists
    • J.J.J. Van Giezen and R.G. Humphries (2005) Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Semin Thromb Hemost 31 195-204.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • Van Giezen, J.J.J.1    Humphries, R.G.2
  • 208
    • 10044241601 scopus 로고    scopus 로고
    • Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.
    • Chhatriwala, M., Ravi, R. G., Patel, R. I., Boyer, J. L., Jacobson, K. A., & Harden, TK, ••. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther, 311, 1038-
    • J Pharmacol Exp Ther, , vol.311 , pp. 1038-
    • Chhatriwala, M.1    Ravi, R.G.2    Patel, R.I.3    Boyer, J.L.4    Jacobson, K.A.5    Harden, T.K.6
  • 209
    • 18044398749 scopus 로고    scopus 로고
    • Pharmacology of CS-747 (Prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity
    • Y. Niitsu, J.A. Jakubowski, A. Sugidachi and F. Asai (2005) Pharmacology of CS-747 (Prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity. Semin Thromb Hemost 31 184-194.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 184-194
    • Niitsu, Y.1    Jakubowski, J.A.2    Sugidachi, A.3    Asai, F.4


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