Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets

Blood

Volumn 94, Issue 5, 1999, Pages 1665-1672

  Bauer, Markus ^b   Retzer, Michaela ^b   Wilde, Jonathan I ^b   Maschberger, Petra ^b   Essler, Markus ^b   Aepfelbacher, Martin ^b   Watson, Steve P ^b   Siess, Wolfgang ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; CALCIUM; COLLAGEN; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; IONOMYCIN; MYOSIN; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN KINASE INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN); RHO FACTOR; THROMBIN; THROMBIN RECEPTOR; THROMBOCYTE RECEPTOR; THROMBOXANE RECEPTOR;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE SHAPE;

EID: 0033199252     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.5.1665.417k33_1665_1672     Document Type: Article

References (32)

1. Siess W: Molecular mechanisms of platelet activation. Physiol Rev 69:58, 1989
2. Fox JE: Regulation of platelet function by the cytoskeleton. Adv Exp Med Biol 344:175, 1993
3. 2+-independent activation for shape-change and secretion. FEBS Lett 148:21, 1982
4. i. FEBS Lett 201:301, 1986
5. Rasmussen UB, Gachet C, Schlesinger Y, Hanau D, Ohlmann P, Van Obberghen-Schilling E, Pouyssegur J, Cazenave JP, Pavirani A: A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets. J Biol Chem 268:14322, 1993
6. 2+-independent mechanism. J Biol Chem 270:1057, 1995
7. 2+ pathway in rabbit platelets. Br J Pharmacol 117:1095, 1996
8. Daniel JL, Molish IR, Rigmaiden M, Stewart G: Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response. J Biol Chem 259:9826, 1984
9. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K: Phosphorylation and activation of myosin by Rho-associated kinase(Rho-kinase). J Biol Chem 271:20246, 1996
10. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K: Regulation of myosin phosphatase by Rho and Rho-associated kinase(Rho-kinase). Science 273:245, 1996
11. Nakai K, Suzuki Y, Kihira H, Wada H, Fujioka M, Ito M, Nakano T, Kaibuchi K, Shiku H, Nishikawa M: Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation. Blood 90:3936, 1997
12. Essler M, Amano M, Kruse HJ, Kaibuchi K, Weber PC, Aepfelbacher M: Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. J Biol Chem 273:21867, 1998
13. Chihara K, Amano M, Nakamura N, Yano T, Shibata M, Tokui T, Ichikawa H, Ikebe R, Ikebe M, Kaibuchi K: Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J Biol Chem 272:25121, 1997
14. Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M: Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 272:12257, 1997
15. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S: Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990, 1997
16. 1 integrin-independent platelet reactivity. Biochem J 306:337, 1995
17. Blake RA, Schieven GL, Watson SP: Collagen stimulates ryrosine phosphorylation of phospholipase C-γ2, but not of phospholipase C-γ1 in human platelets. FEBS Lett 353:212, 1994
18. Siess W, Lapetina E: Functional relationship between cyclic AMP-dependem protein phosphorylation and platelet inhibition. Biochem J 271:815, 1990
19. 3. Blood 91:4206, 1998
20. Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP: Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain. FEBS Lett 413:255, 1997
21. Barnes MJ, Knight G, Farndale RD: The collagen-platelet interaction. Curr Opin Hematol 5:314, 1998
22. Kehrel BS, Wierwille S, Clemetson KJ, Anders O, Steiner M, Knight CG, Farndale RW, Okuma M, Barnes MJ: Glycoprotein VI is a major collagen receptor for platelet activation: It recognizes the platelet quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood 91:491, 1998
23. q-deficient mice. Nature 389:183, 1997
24. Leung T, Chen X-Q, Tan I, Manser E, Lim L: Myotonie dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal organization. Mol Cell Biol: 130, 1998
25. 3-mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets. J Biol Chem 270:17321, 1995
26. Goto H, Kosako H, Tanabe K, Yanagida M, Sakurai M, Amano M, Kaibuchi K, Inagaki M: Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem 273:11728, 1998
27. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, Tsukita S: Rho-kinase phosphorylates COOH-terminal threonines of ezrin/ radixin/ moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 140:647, 1998
28. 13 results in shape change and Rho/Rhokinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745, 1999
29. 2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA 91:504, 1994
30. 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 270:24631, 1995
31. 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation. Blood 92:152, 1998
32. 1. Blood 89:1235, 1997