ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Gαq

Blood

Volumn 96, Issue 6, 2000, Pages 2134-2139

  Ohlmann, P ^a   Eckly, A ^a   Freund, M ^a   Cazenave, J P ^a   Offermanns, S ^a   Gachet, C ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ADENYLATE CYCLASE; AR C66096; BETA,GAMMA DICHLOROMETHYLENE 2 PROPYLTHIOADENOSINE TRIPHOSPHATE; CALCIUM; CANGRELOR; CLOPIDOGREL; COLLAGEN; GUANINE NUCLEOTIDE BINDING PROTEIN; PURINE P2 RECEPTOR; THROMBIN; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; ENZYME INHIBITION; HEMOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; THROMBOCYTE AGGREGATION; THROMBOCYTE SHAPE;

EID: 0034665782     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2134     Document Type: Article

References (42)

1. New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies
2. Signaling through G proteins in platelets: To the integrin and beyond
3. Defective platelet activation in Gαq-deficient mice
4. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
5. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
6. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways
7. Platelet aggregation and its reversal
8. Agonists and receptors: Adenosine diphosphate
9. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
10. 1 receptor is necessary for ADP-induced platelet aggregation
11. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
12. 1 receptor null mice
13. 1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation
14. 2 proteins
15. ADP receptors and clinical bleeding disorders
16. 1 purinoceptor in ADP-induced platelet activation
17. 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
18. A novel series of P(2T) purinoceptor antagonists: Definition of the role of ADP in arterial thrombosis
19. Molecular basis for ADP-induced platelet activation, I: Evidence for three distinct ADP receptors on human platelets
20. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
21. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets
22. L'agregation plaquettaire: Outil d'investigation clinique et d'etude pharmacologique, methodologie
23. Gene cloning of rat and mouse platelet glycoprotein V. Identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage
24. Development of a monoclonal antibody against the extra-cellular domain of platelet GPIBb and its use to analyse recombinant GPIb-V-IX in transfected CHO and K562 cells [abstract]
25. Epinephrine potentiates human platelet activation but is not an aggregating agent
26. An analytical system for rapid separation of tissue nucleotides at low pressures on conventional anion exchangers
27. 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
28. 1 receptor
29. Platelet receptors for collagen
30. Collagen receptor signalling in platelets: Extending the role of the ITAM
31. Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets: Evidence for the unidirectional control of platelet function by cyclic AMP
32. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in Fcgam-maRIIA-mediated activation of human platelets
33. A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets
34. cAMP is not an important messenger for ADP-induced platelet aggregation
35. Platelet aggregation caused by dithiothreitol
36. Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia
37. Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates
38. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
39. Abnormal tyrosine phosphorylation linked to a defective interaction between ADP and its receptor on platelets
40. Inhibition of sulfhydryl-dependent platelet functions by penetrating and non-penetrating analogues of parachloromercuribenzene
41. Modification of platelet functions by monobromobimane, a fluorescent thiol group label
42. Structure and activity of the active metabolite of clopidogrel