A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase

Blood

Volumn 94, Issue 12, 1999, Pages 4156-4165

  Trumel, Catherine ^b   Payrastre, Bernard ^a   Plantavid, Monique ^b   Hechler, Béatrice ^b   Viala, Cécile ^b   Presek, Peter ^b   Martinson, Elizabeth A ^b   Cazenave, Jean Pierre ^b   Chap, Hugues ^b   Gachet, Christian ^b  

^a CHU PURPAN   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; APYRASE; MYOSIN HEAVY CHAIN; PAR1 ACTIVATING PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PURINE P2 RECEPTOR; THROMBIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 13044263119     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.12.4156     Document Type: Article

References (47)

1. Toker A, Cantley LC: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673, 1997
2. 2+ or functional integrin. Biochem J 286:581, 1992
3. Guinebault C, Payrastre B, Racaud-Sultan C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H: Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J Cell Biol 129:831, 1995
4. Nolan RD, Lapetina EG: Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem 265:2441, 1990
5. Sultan C, Breton M, Maucu G, Grondin P, Plantavid M, Chap H: The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human platelets upon thrombin stimulation. Biochem J 269:831, 1990
6. Kucera GL, Rittenhouse SE: Human platelets form 3-phosphorylated phosphoinositides in response to α-thrombin, U46619, or GTPγS. J Biol Chem 265:5345, 1990
7. 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3́-4́-bisphosphate. J Biol Chem 266:23554, 1991
8. Haimovich B, Lipfert L, Brugge JS, Shattil SJ: Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem 268:15868, 1993
9. 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′-bisphosphate accumulation. FEBS Lett 389:253, 1996
10. Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH: Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 270:11358, 1995
11. Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A: D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem 271:32986, 1996
12. Gachet C, Payrastre B, Guinebault C, Trumel C, Ohlmann P, Mauco G, Cazenave JP, Plantavid M, Chap H: Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate. J Biol Chem 272:4850, 1997
13. Mills DC: ADP receptors on platelets. Thromb Haemost 76:835, 1996
14. Gachet C, Hechler B, Léon C, Vial C, Leray C, Ohlmann P, Cazenave JP: Activation of ADP receptors and platelet function. Thromb Haemost 78:271, 1997
15. Martinson EA, Scheible S, Marx-Grunwitz A, Presek P: Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets. Thromb Haemost 80:976, 1998
16. Cattaneo M, Canciani MT, Lecchi A, Kinlough-Rathhone RL, Packham MA, Mannucci PM, Mustard JF: Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates. Blood 75:1081, 1990
17. Kinlough-Rathhone RL, Packham MA, Perry DW, Mustard JF, Cattaneo M: Lack of stability of aggregates after thrombin-induced reaggregation of thrombin-degranulated platelets. Thromb Haemost 67:453, 1992
18. Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP: Molecular basis for ADP-induced platelet activation. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 273:2024, 1998
19. Savi P, Beauverger P, Labouret C, Delfaud M, Salel V, Kaghad M, Herbert JM: Role of P2Y1 purinoceptor in ADP-induced platelet activation. FEBS Lett 422:291, 1998
20. Hechler B, Léon C, Vial C, Vigne P, Frelin C, Cazenave JP, Gachet C: The P2Y1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation. Blood 92:152, 1998
21. Jin J, Kunapuli SP: Coactivation of two different G protein-coupled receptors is essential for ADP-induccd platelet aggregation. Proc Natl Acad Sci USA 95:8070, 1998
22. Jantzen H-M, Gousset L, Bhaskar V, Vincent D, Tai A, Reynolds EE, Conley PB: Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation. Thronib Haemost 81:111, 1999
23. North RA, Barnard EA: Nucleotide receptors. Curr Opin Neurobiol 7:346, 1997
24. Boyer JL, Romero-Avila T, Schachter JB, Harden TK: Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol 50:1323, 1996
25. Herbert JM, Frehel D, Kieffer G, Gouy D, Berger Y, Necciari J, Defreyn G, Maffrand JP: Clopidogrel, a novel antiplatelet and antithrombotic agent. Cardiovasc Drug Rev 11:180, 1993
26. Lau LF, Pumiglia K, Côté YP, Feinstein MB: Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators. Biochem J 303:391, 1994
27. Cazenave JP, Hemmendinger S, Beretz A, Sutter-Bay A, Launay J: Platelet aggregation: A tool for clinical investigation and pharmacological study. Methodology. Ann Biol Clin 41:167, 1983
28. Humphries RG, Robertson MJ, Leff P: A novel series of P2T purinoceptor antagonists: Definition of the role of ADP in arterial thrombosis. Trends Pharmacol Sci 16:179, 1995
29. Gratacap MP, Payrastre B, Viala C, Mauco G, Plantyvid M, Chap H: Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human platelets. J Biol Chem 273:24314, 1998
30. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP: Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82:643, 1995
31. 2 synthesis. Throinb Haemost 79:1184, 1998
32. Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H: Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets. J Biol Chem 272:26857, 1997
33. Zhang J, Bantic H, Straforini F, Tosi L, Volinia S, Rittenhouse SE: A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. J Biol Chem 273:14081, 1998
34. Hemler ME: Integrin associated proteins. Curr Opin Cell Biol 10:578, 1998
35. 2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production. Thromb Haemost 77:986, 1997
36. 3d. Chung J, Gao AG, Frazier WA: Thrombospondin acts via integrin-associated protein to activate the platelet integrin alphaIIb-beta3. J Biol Chem 272:14740, 1997
37. Born GV: Adenosine diphosphate as a mediator of platelet aggregation in vivo: An editorial view. Circulation 72:741, 1985
38. Gachet C, Cattaneo M Ohlmann P, Hechler B, Lecchi A, Chevalier J, Cassel D, Mannuccio Mannucci P, Cazenave JP: Purinoceptors on blood platelets: Further pharmacological and clinical evidence to suggest the presence of two ADP receptors. Br J Haematol 91:434, 1995
39. Nurden P, Savi P, Heilmann E, Bihour C, Herbert JM, Maffrand JP, Nurden A: An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. J Clin Invest 95:1612, 1995
40. Vassallo RR, Kieber-Emmons T, Cichowski K, Brass LF: Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 267:6081, 1992
41. Ohlmann P, Laugwitz K-L, Nürnberg B, Spicher K, Schultz G, Casenave J-P, Gachet C: The human platelet ADP receptor activates Gi2 proteins. Biochem J 312:775, 1995
42. Giesberts AN, Van Willigen G. Lapetina EG, Akkerman J-W: Regulation of platelet glycoprotein IIb/IIIa (integrin αIIβ3) function via the thrombin receptor. Biochem J 309:613, 1995
43. Lerea KM, Glomset JA, Krebs EG: Agents that elevate cAMP levels in platelets decrease thrombin binding. J Biol Chem 262:282, 1987
44. Kovacsovics TJ, Hartwig JH: Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood 87:618, 1996
45. Klages B, Branch U, Simon MI, Schultz G, Offermanns S: Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745, 1999
46. 3 and its ligand and induces selective movement of ligand-occupied integrin. J Biol Chem 271:7004, 1996
47. Heraud JM, Racaud-Sultan C, Gironcel D, Albigès-Rizo C, Giacomini T, Roques S, Martel V, Breton-Douillon M, Perret B, Chap H: Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4′,5′-hisphosphate are both required for ADP-dependent platelet spreading. J Biol Chem 273:17817, 1998