Coordinated signaling through both G12/13 and Gi pathways is sufficient to activate GPIIb/IIIa in human platelets

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 47588-47595

  Dorsam, Robert T ^a   Kim, Soochong ^a   Jin, Jianguo ^a   Kunapuli, Satya P ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CALCIUM; ENZYME INHIBITION; MOLECULES; PROTEINS;

PLATELETS;

BIOCHEMICAL ENGINEERING;

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALPHA 2A ADRENERGIC RECEPTOR; CALCIUM; DIMETHYL ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FIBRINOGEN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 2B; GUANINE NUCLEOTIDE BINDING PROTEIN 3A; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN P160; PROTEINASE ACTIVATED RECEPTOR 1; PURINE P2Y RECEPTOR; THROMBIN; THROMBOXANE A2; TYROSYLPHENYLALANYLLEUCYLLEUCYLARGINYLASPARAGYLPROLINE; UNCLASSIFIED DRUG; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; CHELATING AGENT; CYCLIC AMP; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MAP3K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN SERINE THREONINE KINASE; RHO KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE;

ARTICLE; CALCIUM CELL LEVEL; CHELATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LOW DRUG DOSE; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOCYTE AGGREGATION; THROMBOCYTE STRUCTURE; BIOLOGICAL MODEL; CHEMISTRY; ELECTROPHYSIOLOGY; METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

RICKETTSIA SP. PAR; STAPHYLOCOCCUS PHAGE 3A;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOSINE DIPHOSPHATE; BLOOD PLATELETS; CALCIUM; CHELATING AGENTS; CYCLIC AMP; EGTAZIC ACID; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; EPINEPHRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE KINASE 1; MODELS, BIOLOGICAL; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; THROMBOXANE A2;

EID: 0037032558     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208778200     Document Type: Article

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