ADP is not an agonist at P2X1 receptors: Evidence for separate receptors stimulated by ATP and ADP on human platelets

British Journal of Pharmacology

Volumn 131, Issue 1, 2000, Pages 108-114

  Mahaut Smith, Martyn P ^a   Ennion, Steven J ^b   Rolf, Michael G ^a   Evans, Richard J ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

ADP; Hexokinase; P2 receptors; Platelets; Purinoceptors

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; CALCIUM; HEXOKINASE; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE P2X1 RECEPTOR; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; KINETICS; MALE; MEGAKARYOCYTE; MEMBRANE CURRENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; THROMBOCYTE; XENOPUS;

EID: 0033821625     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703517     Document Type: Article

References (57)

1. 3) receptor
2. The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors
3. P2Y receptors: In the middle of the road
4. 2 purinoceptors on vascular endothelial cells: Physiological significance and transduction mechanisms
5. Aggregation of blood platelets by adenosine diphosphate and its reversal
6. Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man
7. An antagonist-insensitive P(2X) receptor expressed in epithelia and brain
8. Overview. Purinergic Mechanisms
9. A P2X purinoceptor expressed by a subset of sensory neurons
10. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
11. Role of intracellular signalling events in ADP-induced platelet aggregation
12. 2+ activates phospholipase C
13. 2-purinoceptors in the smooth muscle of the rat tail artery: A comparison between contractile and electrophysiological responses
14. Pharmacological characterization of heterologously expressed ATP-gated cation channels (P(2X) purinoceptors)
15. P2X receptors: Cloned and expressed
16. 1-deficient mice
17. -P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets
18. Towards a revised nomenclature for P1 and P2 receptors. TIPS
19. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets
20. 1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation
21. 1 receptor: Similarities to the platelet ADP receptor
22. Secretable storage pools in platelets
23. Receptors for ADP on human blood platelets
24. High-performance liquid chromatographic assay of the diadenosine polyphosphates in human platelets
25. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
26. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
27. 2+-permeable cation channels in mouse, rat and guinea-pig megakaryocytes: A patch clamp study
28. 2 receptor subtypes in the cardiovascular system
29. 1 receptor-null mice
30. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
31. 3 receptor subunits can account for ATP-gated currents in sensory neurons
32. Effects of diadenosine polyphosphates (Ap(n)As) and adenosine polyphospho guanosines (Ap(n)Gs) on rat mesenteric artery P2X receptor ion channels
33. 1 not P2T purinoceptors in human platelets
34. 2+ release in a non-excitable cell, the rat megakaryocyte
35. Receptor-activated single channels in intact human platelets
36. Rapid ADP-evoked currents in human platelets recorded with the nystatin permeabilized patch technique
37. 1 receptors
38. 2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor
39. Nucleotide receptors
40. The human platelet ADP receptor activates G(i2) proteins
41. 1 receptor
42. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways
43. Receptors for purines and pyrimidines
44. 1 purinoceptors in human platelets
45. Purinoceptor-evoked calcium signalling in human platelets
46. 2+ store
47. The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets
48. Resting and ADP-evoked changes in cytosolic free sodium concentration in human platelets loaded with the indicator SBFI
49. Role of P2Y1 purinoceptor in ADP-induced platelet activation
50. Characterization of P2x1 purinoceptors on rat platelets: Effect of clopidogrel
51. Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes
52. 7)
53. 2+ oscillation in rat megakaryocytes evoked by a novel type of purinoceptor
54. A new class of ligand-gated ion channel defined by P(2X) receptor for extracellular ATP. Nature
55. 1 purinoceptors in human platelets and megakaryoblastic cell lines
56. Differential distribution of two ATP-gated ion channels (P(2X) receptors) determined by immunocytochemistry
57. Selectivity of diadenosine polyphosphates for rat P2X receptor subunits