Selective inhibitors of inducible nitric oxide synthase: Potential agents for the treatment of inflammatory diseases?

Current Topics in Medicinal Chemistry

Volumn 6, Issue 2, 2006, Pages 77-92

  Tinker, Alan C ^a   Wallace, Alan V ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

cGMP; Cofactors; Crystallography; Guanidine; Phosphorylation; Physicochemical properties; Simple carbamidines

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; 1,1 DIMETHYLGUANIDINE; AMIDINE; AMINODIHYDROTHIAZOLE DERIVATIVE; AMINOETHYLISOTHIOURONIUM; AMINOGUANIDINE; AMINOGUANIDINE DERIVATIVE; ANTIINFLAMMATORY AGENT; ARGININE; ARGININE DERIVATIVE; CANAVANINE; GUANIDINE DERIVATIVE; GW 273629; HOMOARGININE; INDUCIBLE NITRIC OXIDE SYNTHASE; METHYLGUANIDINE; N(G) METHYLARGININE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; S BENZYLISOTHIOUREA; S ETHYLISOTHIOUREA; SC 51; TETRAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; THIOUREA DERIVATIVE; U 19451A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BINDING SITE; CHRONIC INFLAMMATION; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME SUBSTRATE; HUMAN; INFLAMMATORY DISEASE; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ENZYME INHIBITORS; HUMANS; INFLAMMATION; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE II; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646169337     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606775270297     Document Type: Review

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