Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: Crystallographic and computational analyses of inhibitor potency

Biochemistry

Volumn 41, Issue 47, 2002, Pages 13915-13925

  Rosenfeld, Robin J ^a   Garcin, Elsa D ^a   Panda, Koustubh ^b   Andersson, Gunilla ^c   Åberg, Anders ^c   Wallace, Alan V ^d   Morris, Garrett M ^a   Olson, Arthur J ^a   Stuehr, Dennis J ^b   Tainer, John A ^a   Getzoff, Elizabeth D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c ASTRAZENECA R AND D   (Sweden)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES;

COMPUTATIONAL METHODS; CONFORMATIONS; HYDROGEN BONDS; PHYSIOLOGY; PROTEINS; SIGNALING; X RAY CRYSTALLOGRAPHY;

BIOCHEMISTRY;

3 BROMO 7 NITROINDAZOLE; 5 NITROINDAZOLE; 6 NITROINDAZOLE; 7 NITROINDAZOLE; CHLORZOXAZONE; INDAZOLE DERIVATIVE; NITRIC OXIDE SYNTHASE; NITROINDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; INHIBITION KINETICS; MOLECULAR RECOGNITION; PREDICTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CHLORZOXAZONE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDAZOLES; ISOENZYMES; MODELS, MOLECULAR; MUSCLE RELAXANTS, CENTRAL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; NITRO COMPOUNDS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 18744380020     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026313j     Document Type: Article

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