Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase

Biochemical Journal

Volumn 320, Issue 1, 1996, Pages 193-196

  Werner, Ernst R ^a   Pitters, Eva ^b   Schmidt, Kurt ^b   Wachter, Helmut ^a   Werner Felmayer, Gabriele ^a   Mayer, Bernd ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ENZYME; DIHYDROPTERIDINE REDUCTASE; NITRIC OXIDE SYNTHASE; PTERIDINE; TETRAHYDROBIOPTERIN;

ARTICLE; BRAIN METABOLISM; CELL METABOLISM; CONTROLLED STUDY; DIASTEREOISOMER; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION;

EID: 0029827739     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3200193     Document Type: Article

References (18)

1. Griffith, O. W. and Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736
2. Moncada, S., Palmer, R. M. and Higgs, E. A. (1991) Pharmacol. Rev. 43, 109-142
3. Werner, E. R., Werner-Felmayer, G., Wachter, H. and Mayer, B. (1995) Rev. Physiol. Biochem. Pharmacol. 127, 95-135
4. Baek, K. J., Thiel, B. A., Lucas, S. and Stuehr, D. J. (1993) J. Biol. Chem. 268, 21120-21129
5. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bachinger, H. P. and Mayer, B. (1995) EMBO. J. 14, 3687-3695
6. Mayer, B. and Werner, E. R. (1995) Naunyn-Schmiedebergs Arch. Pharmacol. 351, 453-463
7. Giovanelli, J., Campos, K. L. and Kaufman, S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7091-7095
8. Witteveen, C. F. B., Giovanelli, J. and Kaufman, S. (1996) J. Biol. Chem. 271, 4143-4147
9. Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R. and Mayer, B. (1994) J. Biol. Chem. 269, 13861-13866
10. Werner, E. R., Schmid, M., Werner-Felmayer, G., Mayer, B. and Wachter, H. (1994) Biochem. J. 304, 189-193
11. Harteneck, C., Klatt, P., Schmidt, K. and Mayer, B. (1994) Biochem. J. 304, 683-686
12. Mayer, B., List, B. M., Klatt, P., Harteneck, C. and Schmidt, K. (1996) Methods Enzymol. 268, 420-427
13. Mayer, B., Klatt, P., Werner, E. R. and Schmidt, K. (1994) Neuropharmacology 33, 1253-1259
14. Brunner, F. and Kukovetz, W. R. (1991) Br. J. Pharmacol. 102, 373-380
15. Klatt, P., Pfeiffer, S., List, B. M., Lehner, D., Glatter, O., Bachinger, H. P., Werner, E. R., Schmidt, K. and Mayer, B. (1996) J. Biol. Chem. 271, 7336-7342
16. Craine, J. E., Hall, E. S. and Kaufman, S. (1972) J. Biol. Chem. 247, 6082-6091
17. Whiteley, J.M, Varughese, K. I., Xuong, N. H., Matthews, D. A. and Grimshaw, C. E. (1993) Pteridines 4, 159-173
18. Mayer, B., John, M., Heinzel, B., Werner, E. R., Wachter, H., Schultz, G. and Böhme, E. (1991) FEBS Lett. 288, 187-191