Novel and orally bioavailable inducible nitric oxide synthase inhibitors: Synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1361-1366

  Ueda, Shigeo ^a   Terauchi, Hideo ^a   Suzuki, Kenji ^a   Yano, Akihiro ^a   Matsumoto, Masashi ^a   Kubo, Taeko ^a   Minato, Hisao ^a   Arai, Yukiyo ^a   Tsuji, Jun Ichi ^a   Watanabe, Nobuhide ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

iNOS; Selectivity; Selenazolidine

Indexed keywords

ES 2133; NITRIC OXIDE SYNTHASE INHIBITOR; SELENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG SCREENING; DRUG SYNTHESIS; OPTICS;

EID: 13944280212     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.01.013     Document Type: Article

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30. D +139 (c 0.84, MeOH). Characteristic data for other novel compounds (4a-c, 8, and 8a-c) were given in Supplementary data
31. -1; T = 100(2) K; R = 0.0223; S = 1.017. Flack's χ parameter (0.016(7)) indicated that the absolute configuration at the 4- and 5-positions of compound 4 is R,R. Full information on the crystal structure can be ordered from Cambridge Crystallographic Data Centre (CCDC), deposition number CCDC 257366