The natural product noformycin is an inhibitor of inducible-nitric oxide synthase

Biochemical and Biophysical Research Communications

Volumn 225, Issue 2, 1996, Pages 621-626

  Green, Barbara Gordon ^a   Chabin, Renee ^a   Grant, Stephan K ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b R80M 136 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NOFORMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; ENZYME INHIBITION; ENZYME KINETICS; PRIORITY JOURNAL;

EID: 0030583298     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.1220     Document Type: Article

References (45)

1. 1. For reviews concerning nitric oxide synthases see: (a) Marletta, M. A. (1989) TIBS 14, 488-492;
2. (b) Nathan, C. (1992) FASEB J. 6, 3051-3064;
3. (c) Lowenstein, C. J., and Snyder, S. H. (1992) Cell 70, 705-707.
4. 2. White, K. A., and Marletta, M. A. (1992) Biochem. 31(29), 6627-6631.
5. 3. Stuehr, D. J., and Ikeda-Saito, M. (1992) J. Biol. Chem. 267(29), 20547-20550.
6. 4. McMillan, K., and Masters, B. S. S. (1993) Biochem. 32(38), 9876-9880.
7. 5. Kwon, N. S., Nathan, C. F., and Stuehr, D. J. (1989) J. Biol. Chem. 264(3), 20496-20501.
8. 6. Stuehr, D. J., Kwon, N. S., and Nathan, C. F. (1990) Biochem. Biophys. Res. Comm. 168(2), 558-565.
9. 7. Gross, S. S., Stuehr, D. J., Aisaka, K., Jaffe, E. A., Levi, R., and Griffith, O. W. (1990) Biochem. Biophys. Res. Comm. 170(1), 96-103.
10. 8. Gross, S. S., Jaffe, E. A., Levi, R., and Kilbourn, R. G. (1991) Biochem. Biophys. Res. Comm. 178(3), 823-829.
11. 9. Lambert, L. E., Whitten, J. P., Baron, B. M., Cheng, H. C., Doherty, N. S., and McDonald, I. (1991) Life Sciences 48, 69-75.
12. 10. Joly, G. A., Ayres, M., Chelly, F., and Kilbourn, R. G. (1994) Biochem. Biophys. Res. Comm. 199(1), 147-154.
13. 11. Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., and Nathan, C. F. (1991) FASEB J. 5, 98-103.
14. 12. O'Donnell, V. B., Smith, G. C. M., and Jones, O. T. G. (1994) Molec. Pharmacol. 46, 778-785.
15. 13. Pfeiffer, C. J., and Qiu, B. S. (1995) J. Pharm. Pharmacol. 47, 827-832.
16. 14. Cattell, V., and Jansen, A. (1995) Histochem. J. 27, 777-784.
17. 15. Lyons, C. R. (1995) Adv. Immunol. 60, 323-371.
18. 16. Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A., and Evans, C. H. (1994) Arthritis & Rheumatism 37(7), 1062-1069.
19. 17. Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A., and Evans, C. H. (1995) J. Rheumatol. 22(10), 1922-1928.
20. 18. Connor, J. R., Manning, P. T., Settle, S. L., Moore, W. M., Jerome, G. M., Webber, R. K., Tjoeng, F. S., and Currie, M. G. (1995) Eur. J. Pharmacol. 273(1-2), 15-24.
21. 19. Harris, D. A., and Woodruff, H. B. (1954) Antibiot. Annu. 1954, 609-614.
22. 20. McClelland, L. (1954) Antibiot. Annu. 1954, 615.
23. 21. Peck, R. L., Peck, H. M., Shafer, H. M., and Wolf, F. J. (1957) U.S. patent 2,804,463 (Merck & Co.).
24. 22. Diana, G. D. (1973) J. Med. Chem. 16(7), 857-859.
25. 23. Furasawa, Cutting, P., Buckley, P., and Furusawa, S. (1964) Proc. Soc. Exp. Biol. Med. 116, 938-944.
26. 24. Southan, G. J., Szabó, C., O'Connor, M. P., Salzman, A. L., and Thiemermann, C. (1995) Eur. J. Pharmacol. 291, 311-318.
27. 25. Moore, W. M., Webber, R. K., Fok, K. F., Jerome, G. M., Connor, J. R., Manning, P. T., Wyatt, P. S., Misko, T. P., Tjoeng, F. S., and Currie, M. G. (1996) J. Med. Chem. 39, 669-672.
28. 26. Calaycay, J., McCauley, E., Griffin, P., Wong, K., Kelly, T., Geller, D., MacNaul, K., Hutchinson, N., Williams, H., Mumford, R., and Schmidt, J. (1996) in The Biology of Nitric Oxide: Part 5 (S. Moncada, J. Stamler, S. Gross, and E. A. Higgs, Eds.), p. 56. Portland Press, London, U.K.
29. 27. Robertson, C. A., Green, B. G., Niedzwiecki, L., Harrsion, R. K., and Grant, S. K. (1993) Biochem. Biophys. Res. Comm. 197(2), 523-528.
30. 28. Saltzman, B. E. (1954) Anal. Chem. 26(12), 1949-1955.
31. 29. Dixon, M. (1953) Biochem. J. 55, 161.
32. 30. Chabin, R. M., McCauley, E., Calaycay, J. R., Kelly, T. M., MacNaul, K. L., Wolfe, G. C., Hutchinson, N. I., Madhusudana, S., Schmidt, J. A., Kozarich, J. W., and Wong, K. K. (1996) Biochemistry, in press.
33. 31. Feldman, P. L., Chi, S., Sennequier, N., and Stuehr, D. J. (1996) Bioorg. Med. Chem. Lett. 6(1), 111-114.
34. 32. Beauman, B. L., Burnside, J., Edwards, B., and Causey, W. (1976) J. Infec. Dis. 134(286), 1972-1974.
35. 33. Filice, G. A. (1987) J. Infec. Dis. 156, 113-21.
36. 34. Beaman, B. L., and Beaman, L. (1994) Clin. Microl. Rev. 7, 818-826.
37. 35. Nathan, C., and Hibbs, J., Jr. (1991) Curr. Opin. Immunol. 3, 65-70.
38. 36. Nathan, C., and Xie, Q.-w. (1994) Cell 78, 915-918.
39. 37. MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q.-w., Sokol, K., Hutchinson, N. I., Chen, H., and Mudgett, J. S. (1995) Cell 81, 641-650.
40. 38. Chen, Y., and Rosazza, J. P. N. (1994) Biochem. Biophys. Res. Comm. 203(2), 1251-1258.
41. 39. Chen, Y., and Rosazza, J. P. N. (1995) J. Bacteriol. 177(17), 5122-5128.
42. 40. Furchgott, R. F., and Zawadzki, J. V. (1980) Nature 288, 373-376.
43. 41. Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G. (1987) Proc. Natl. Acad. Sci. USA 84, 9265-9269.
44. 42. Palmer, R. M. J., Ferrige, A. G., and Moncada, S. (1987) Nature 327, 524.
45. 43. Garthwaite, J., Charles, S. L., and Chess-Williams, R. (1988) Nature 336, 385-388.