Implications for Isoform-selective Inhibitor Design Derived from the Binding Mode of Bulky Isothioureas to the Heme Domain of Endothelial Nitric-oxide Synthase

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26486-26491

  Raman, C S ^a,d   Li, Huiying ^a   Martásek, Pavel ^b   Babu, Boga Ramesh ^c,e   Griffith, Owen W ^c   Masters, Bettie Sue S ^b   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e Diagnostic Systems Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; NITROGEN COMPOUNDS; PATHOLOGY;

PHYSIOLOGICAL FUNCTIONS;

BIOCHEMISTRY;

CITRULLINE; HEME; N(G) HYDROXYARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THIOUREA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; ISOPROTEIN; NOS3 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY DIFFRACTION; ANIMAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; PROTEIN BINDING;

ANIMALS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HEME; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN BINDING; PROTEIN ISOFORMS; THIOUREA;

EID: 0035854721     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102255200     Document Type: Article

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