2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS)

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1361-1366

  Hansen Jr , Donald W ^a   Peterson, Karen B ^a   Trivedi, Mahima ^a   Kramer, Steven W ^a   Webber, Ronald K ^a   Tjoeng, Foe S ^a   Moore, William M ^a   Jerome, Gina M ^a   Kornmeier, Christine M ^a   Manning, Pamela T ^a   Connor, Jane R ^a   Misko, Thomas P ^a   Currie, Mark G ^a   Pitzele, Barnett S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 IMINOHOMOPIPERIDINIUM SALT; HEXAHYDRO 3 (2 PROPOENYL) 1H AZEPIN 2 IMINE MONOHYDROCHLORIDE; HEXAHYDRO 7 PROPYL 1H AZEPIN 2 IMINE MONOHYDROCHLORIDE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ENTERITIS; ENZYME INHIBITION; ENZYME LOCALIZATION; MOUSE; NONHUMAN; OSTEOARTHRITIS; RAT; RHEUMATOID ARTHRITIS; SEPSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZEPINES; BIOLOGICAL AVAILABILITY; CELL LINE; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; IMINES; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0042293632     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9704715     Document Type: Article

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