PPA250 [3-(2,4-difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy}-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 1, 2002, Pages 52-57

  Ohtsuka, Mari ^a   Konno, Fujiko ^b   Honda, Haruyoshi ^a   Oikawa, Takayuki ^a   Ishikawa, Masago ^b   Iwase, Nobuhisa ^a   Isomae, Kazuo ^a   Ishii, Fumio ^b   Hemmi, Hiromichi ^a   Sato, Susumu ^a  

^a SSP CO LTD   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DIFLUOROPHENYL) 6 [2 [4 (1H IMIDAZOL 1 YLMETHYL)PHENOXY]ETHOXY] 2 PHENYLPYRIDINE; ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD LEVEL; CHRONIC ARTHRITIS; CONTROLLED STUDY; DIMERIZATION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MALE; MOUSE; NONHUMAN; POLYARTHRITIS; PRIORITY JOURNAL; SEPSIS; STRUCTURE ANALYSIS; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CELL LINE; COLLAGEN; DIMERIZATION; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; IMIDAZOLES; KINETICS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PYRIDINES; SHOCK, SEPTIC;

EID: 0036784509     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.035857     Document Type: Article

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