Diphenyleneiodonium inhibits NF-κB activation and iNOS expression induced by IL-1β: Involvement of reactive oxygen species

Mediators of Inflammation

Volumn 10, Issue 4, 2001, Pages 209-215

  Ferreira Mendes, A ^a,b   Pato Carvalho, A ^b   Margarida Caramona, M ^a   Celeste Lopes, M ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Arthritis; Chondrocyte; Diphenyleneiodonium chloride; Flavonoid containing enzymes; Pro inflammatory cytokines; Reactive oxygen species

Indexed keywords

CYTOKINE; DIPHENYLIODONIUM SALT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTHRITIS; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; FLUORESCENCE; IMMUNOBLOTTING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ANIMALS; CATTLE; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INTERLEUKIN-1; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; ONIUM COMPOUNDS; REACTIVE OXYGEN SPECIES;

ANIMALIA; BOVINAE;

EID: 0034857992     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/09629350120080401     Document Type: Article

References (48)

1. The role of cytokines in the development of osteoarthritis
2. Synovial fluid concentration of five different cytokines in rheumatic disease
3. Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes
4. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1
5. Collagenase and collagenolytic activity in human osteoarthritic cartilage
6. Induction of cyclooxygenase by interleukin 1: Comparative study between human synovial cells and chondrocytes
7. Induction of nitric oxide synthase in human chondrocytes
8. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide
9. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon-gamma and lipopolysaccharide
10. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
11. Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1β and cAMP in rat mesangial cells
12. Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes
13. Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-induced NF-κB activation and iNOS expression in bovine articular chondrocytes
14. Pyrrolidine dithiocarbamate differentially affects interleukin 1β and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells
15. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases
16. Suppression of arthritis by an inhibitor of nitric oxide synthase
17. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase
18. Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L-ornithine, a nitric oxide synthase inhibitor
19. N-Monomethyl-L-arginine, an inhibitor of NOS, suppresses the development of adjuvant arthritis in rats
20. G-monomethyl-L-arginine
21. Chondrocyte apoptosis induced by nitric oxide
22. Interleukin-1β induction of c-fos and collagenase expression in articular chondrocytes: Involvement of reactive oxygen species
23. IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2
24. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production
25. Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate
26. Studies on the inhibitory, mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
27. Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase
28. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs
29. 2 in rat mesangial cells
30. Inverse correlation between tyrosine phosphorylation and collagenase production in chondrocytes
31. 15N]nitrate in biological fluids
32. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
33. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
34. Organometal-induced increases in reactive oxygen species: The potential of 2′,7′-dichlorofluorecein diacetate as an index of neurotoxic damage
35. Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes
36. Redox signaling and the emerging therapeutic potential of thiol antioxidants
37. Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues
38. Generation of reactive oxygen intermediates, activation of NF-κB and induction of apoptosis in human endothelial cells by glucose: Role of nitric oxide synthase?
39. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: Requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants
40. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB
41. Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells
42. Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells
43. Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells
44. Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle
45. An NADPH oxidase superoxide-generating system in the rabbit aorta
46. Endothelial cells potentiate oxidant-mediated Kupffer cell phagocytic killing
47. Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms
48. Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase