Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform

British Journal of Pharmacology

Volumn 117, Issue 4, 1996, Pages 619-632

  Southan, Garry J ^a   Zingarelli, Basilia ^a   O'Connor, Michael ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Blood pressure; EDRF; Endotoxin; Isoform selective inhibition; Isothioureas; Mercaptoalkylguanides; Nitric oxide; Shock; Vasoconstriction; Vasodilatation

Indexed keywords

AMINOETHYLISOTHIOURONIUM; ARGININE; CITRULLINE; ENDOTOXIN; GUANIDINE DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PICRIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CATTLE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0030032721     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15236.x     Document Type: Article

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