Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding

Biochemistry

Volumn 36, Issue 17, 1997, Pages 5097-5103

  Gachhui, Ratan ^a   Ghosh, Dipak K ^a   Wu, Chaoqun ^a   Parkinson, John ^b   Crane, Brian R ^c   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b BAYER AG   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE; OXYGENASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL MUTAGENESIS; ENZYME BINDING; ENZYME STRUCTURE; GENE MUTATION; MATHEMATICAL MODEL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; ANTIOXIDANTS; ARGININE; BIOPTERIN; CATTLE; CHROMATOGRAPHY, GEL; GLUTAMIC ACID; HEME; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE; OXYGENASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ESCHERICHIA COLI;

EID: 0030917621     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970331x     Document Type: Article

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