2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase

Journal of Medicinal Chemistry

Volumn 41, Issue 19, 1998, Pages 3675-3683

  Hagen, Timothy J ^a   Bergmanis, Arija A ^a   Kramer, Steven W ^a   Fok, Kam F ^a   Schmelzer, Albert E ^a   Pitzele, Barnett S ^a   Swenton, Lydia ^c   Jerome, Gina M ^b   Kornmeier, Christine M ^b   Moore, William M ^b   Branson, Linda F ^b   Connor, Jane R ^b   Manning, Pamela T ^b   Currie, Mark G ^b   Hallinan, E Ann ^a  

^a Depts Discov Pharmacol Med Chem   (United States)

^b Discov Pharmacol Searle Monsanto   (United States)

^c Physical Methodology Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYL 5 PENTYLPYRROLIDIN 2 IMINE; NITRIC OXIDE SYNTHASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD PRESSURE; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; IMINES; ISOENZYMES; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED BALB C; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15144344799     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970840x     Document Type: Article

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