Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: Structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO• as a cellular signal

FASEB Journal

Volumn 10, Issue 5, 1996, Pages 552-558

  Masters, B S S ^a   Mcmillan, K ^b   Sheta, E A ^c   Nishimura, J S ^a   Roman, L J ^a   Martasek, P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b PHARMACOPEIA INC   (United States)

^c ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Ca2+ calmodulin; Cysteine thiolate bound heme; FAD and FMN; L arginine; L citrulline; Modular structure; NO ; Tetrahydrobiopterin

Indexed keywords

ARGININE; CALMODULIN; CYTOCHROME P450; HEMOPROTEIN; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROXYLATION; MOLECULAR CLONING; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ARGININE; CYSTEINE; FREE RADICALS; HEMEPROTEINS; HUMANS; HYDROXYLATION; ISOENZYMES; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

EID: 0029966119     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.5.8621055     Document Type: Review

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