Bicyclic amidine inhibitors of nitric oxide synthase: Discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 8, 2005, Pages 1997-2001

  Guthikonda, Ravindra N ^a   Shah, Shrenik K ^a   Pacholok, Stephen G ^a   Humes, John L ^a   Mumford, Richard A ^a   Grant, Stephan K ^a   Chabin, Renee M ^a   Green, Barbara G ^a   Tsou, Nancy ^a   Ball, Richard ^a   Fletcher, Daniel S ^a   Luell, Silvi ^a   Euan MacIntyre, D ^a   MacCoss, Malcolm ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amidine; iNOS; Nitric oxide synthase

Indexed keywords

AMIDINE; IMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY ANALYSIS;

EID: 20144387150     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.067     Document Type: Article

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