2-Aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 3320-3323

  Connolly, Stephen ^a,b   Aberg, Anders ^b   Arvai, Andrew ^c   Beaton, Haydn G ^a   Cheshire, David R ^a   Cook, Anthony R ^a   Cooper, Sally ^a   Cox, David ^a   Hamley, Peter ^a   Mallinder, Phil ^a   Millichip, Ian ^a   Nicholls, David J ^a   Rosenfeld, Robin J ^c   St Gallay, Stephen A ^a   Tainer, John ^c   Tinker, Alan C ^a   Wallace, Alan V ^a  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPYRIDINE; 4 METHYLAMINOPYRIDINE; 4 PIPERIDINE CARBAMATE; AMIDE; AMINOPYRIDINE DERIVATIVE; CARBAMIC ACID; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; NITROGEN; PIPERIDINE DERIVATIVE; PYRIDINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; INFLAMMATION; METHYLATION; REACTION ANALYSIS;

AMINOPYRIDINES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; MICE; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 2542531589     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031035n     Document Type: Article

References (18)

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