Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor

European Journal of Pharmacology

Volumn 509, Issue 1, 2005, Pages 71-76

  Chida, Noboru ^a   Hirasawa, Yoshimi ^a   Ohkawa, Takehiko ^a   Ishii, Yoshinori ^a   Sudo, Yuji ^a   Tamura, Kouichi ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Dimerization; FR260330; Inducible nitric oxide synthase

Indexed keywords

3 (4 CHLOROPHENYL) N [2 OXO 2 [[2 OXO 2 [4 [[6 (TRIFLUOROMETHYL) 4 PYRIMIDINYL]OXY] 1 PIPERIDINYL]ETHYL]AMINO] 1 (2 PYRIDINYLMETHYL)ETHYL] ACRYLAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FR 260330; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IC 50; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN CELL;

EID: 13844271441     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.12.028     Document Type: Article

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