-
1
-
-
0024832408
-
Highly specific inhibition of human immunodefi-ciency virus type 1 by a novel 6-substituted acyclouridine derivative
-
Baba, M., Tanaka, H., De Clercq, E., Pauwels, R., Balzarini, J., Schols, D., Nakashima, H., Perno, C-F., Walker, R.T. and Miyasaka, T. Highly specific inhibition of human immunodefi-ciency virus type 1 by a novel 6-substituted acyclouridine derivative. Biochem. Biophys. Res. Commun. 1989, 165, 1375-1381.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.165
, pp. 1375-1381
-
-
Baba, M.1
Tanaka, H.2
De Clercq, E.3
Pauwels, R.4
Balzarini, J.5
Schols, D.6
Nakashima, H.7
Perno, C.-F.8
Walker, R.T.9
Miyasaka, T.10
-
2
-
-
0024408374
-
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio) thymine
-
Miyasaka, T., Tanaka, H., Baba, M., Hayakawa, H., Walker, R.T., Balzarini, J. and De Clercq, E. A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio) thymine. J. Med. Chem. 1989, 32, 2507-2509.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 2507-2509
-
-
Miyasaka, T.1
Tanaka, H.2
Baba, M.3
Hayakawa, H.4
Walker, R.T.5
Balzarini, J.6
De Clercq, E.7
-
3
-
-
0025014499
-
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
-
Pauwels, R., Andries, K., Desmyter, J., Schols, D., Kukla, M.J., Breslin, H.J., Raeymaeckers, A., Van Gelder, J., Woestenborghs, R., Heykants, J., Schellekens, K., Janssen, M.A.C., De Clercq, E. and Janssen, P.A.J. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 1990, 343, 470-474.
-
(1990)
Nature
, vol.343
, pp. 470-474
-
-
Pauwels, R.1
Andries, K.2
Desmyter, J.3
Schols, D.4
Kukla, M.J.5
Breslin, H.J.6
Raeymaeckers, A.7
Van Gelder, J.8
Woestenborghs, R.9
Heykants, J.10
Schellekens, K.11
Janssen, M.A.C.12
De Clercq, E.13
Janssen, P.A.J.14
-
4
-
-
0032918170
-
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
-
De Clercq, E. Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. Il Farmaco 1999, 54, 26-45.
-
(1999)
Il Farmaco
, vol.54
, pp. 26-45
-
-
De Clercq, E.1
-
5
-
-
0037130296
-
New development in anti-HIV chemotherapy
-
De Clercq, E. New development in anti-HIV chemotherapy. Biochim. Biophys. Acta 2002, 1587, 258-275.
-
(2002)
Biochim. Biophys. Acta
, vol.1587
, pp. 258-275
-
-
De Clercq, E.1
-
6
-
-
0036104758
-
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors; past, present and future perspectives
-
Campani, G., Ramunno, A., Maga, G., Nacci, V., Fattorusso, C., Catalanotti, B., Morelli, E. and Novellino, E. Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors; past, present and future perspectives. Curr. Pharm. Design 2002, 8, 6615-657.
-
(2002)
Curr. Pharm. Design
, vol.8
, pp. 6615-6657
-
-
Campani, G.1
Ramunno, A.2
Maga, G.3
Nacci, V.4
Fattorusso, C.5
Catalanotti, B.6
Morelli, E.7
Novellino, E.8
-
7
-
-
0029096567
-
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
-
Tanaka, H., Takahima, H., Ubasawa, M., Sekiya, K., Inouye, N., Baba, M., Shigeta, S., Walker, R.T., De Clercq, E. and Miyasaka, T. Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. J. Med. Chem. 1995, 38, 2860-2865.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2860-2865
-
-
Tanaka, H.1
Takahima, H.2
Ubasawa, M.3
Sekiya, K.4
Inouye, N.5
Baba, M.6
Shigeta, S.7
Walker, R.T.8
De Clercq, E.9
Miyasaka, T.10
-
8
-
-
0028329454
-
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro
-
Baba, M.M., Shigeta, S., Yuasa, S., Takashima, H., Sekiya, K., Ubasawa, M., Tanaka, H., Miyasaka, T., Walker, R.T. and De Clercq, E. Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro. Antimicrob. Agents Chemother. 1994, 38, 688-692.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 688-692
-
-
Baba, M.M.1
Shigeta, S.2
Yuasa, S.3
Takashima, H.4
Sekiya, K.5
Ubasawa, M.6
Tanaka, H.7
Miyasaka, T.8
Walker, R.T.9
De Clercq, E.10
-
9
-
-
0028029961
-
New tetrahydroimidazo[4,5-1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs
-
Pauwels, R., Andries, K., Debyser, Z., Kukla, M.-J., Schols, D., Breslin, H.J., Woestenborghs, R., Desmyter, J., Janssen, M.A.C., De Clercq, E. and Janssen, P.A.J.New tetrahydroimidazo[4,5-1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs. Antimicrob. Agents Chemother. 1994, 38, 2863-2870.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2863-2870
-
-
Pauwels, R.1
Andries, K.2
Debyser, Z.3
Kukla, M.-J.4
Schols, D.5
Breslin, H.J.6
Woestenborghs, R.7
Desmyter, J.8
Janssen, M.A.C.9
De Clercq, E.10
Janssen, P.A.J.11
-
10
-
-
0026347180
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2
-
Kukla, M.J., Breslin, H.J., Diamond, C.J., Grous, P.P., Ho, C.Y., Miranda, M., Rodgers, J.D., Sherrill, R.G., De Clercq, E., Pauwels, R., Andries, K., Moens, L.J., Janssen, M.A.C. and Janssen, P.A.J Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2. J. Med. Chem. 1991, 34, 3187-3197.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 3187-3197
-
-
Kukla, M.J.1
Breslin, H.J.2
Diamond, C.J.3
Grous, P.P.4
Ho, C.Y.5
Miranda, M.6
Rodgers, J.D.7
Sherrill, R.G.8
De Clercq, E.9
Pauwels, R.10
Andries, K.11
Moens, L.J.12
Janssen, M.A.C.13
Janssen, P.A.J.14
-
11
-
-
0025973691
-
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives
-
Kukla M.J., Breslin, H.J., Pauwels, R., Fedde, C.L., Miranda, M., Scott, M.K., Sherrill, R.G., Raeymaekers, A., Van Gelder, A., Andries, K., Janssen, M.A.C., De Clercq, E. and Janssen, P.A.J. Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives. J. Med. Chem. 1991, 34, 746-751
-
(1991)
J. Med. Chem.
, vol.34
, pp. 746-751
-
-
Kukla, M.J.1
Breslin, H.J.2
Pauwels, R.3
Fedde, C.L.4
Miranda, M.5
Scott, M.K.6
Sherrill, R.G.7
Raeymaekers, A.8
Van Gelder, A.9
Andries, K.10
Janssen, M.A.C.11
De Clercq, E.12
Janssen, P.A.J.13
-
12
-
-
0028029961
-
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs
-
Pauwels, R., Andries, K., Debyzer, Z., Kukla, M.J., Schols, D., Breslin, H.J., Woestenborghs, R., Desmyter, J., Janssen, M.A.C., De Clercq, E. and Janssen, P.A.J. New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2′,3′-dideoxynucleoside analogs. Antimicrob. Agents Chemother. 1994, 38, 2863-2870.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2863-2870
-
-
Pauwels, R.1
Andries, K.2
Debyzer, Z.3
Kukla, M.J.4
Schols, D.5
Breslin, H.J.6
Woestenborghs, R.7
Desmyter, J.8
Janssen, M.A.C.9
De Clercq, E.10
Janssen, P.A.J.11
-
13
-
-
0025679303
-
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
-
Merluzzi, V.J., Hargrave, K.D., Labadia, M., Grozinger, K., Skoog, M., Wu, J.C., Shin, C.-K., Eckner, K., Hattox, S., Adams, J., Rosenthal, A.S., Faanes, R., Eckner, R.J., Koup, R.A. and Sullivan, J.L. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science 1990, 250, 1411-1413.
-
(1990)
Science
, vol.250
, pp. 1411-1413
-
-
Merluzzi, V.J.1
Hargrave, K.D.2
Labadia, M.3
Grozinger, K.4
Skoog, M.5
Wu, J.C.6
Shin, C.-K.7
Eckner, K.8
Hattox, S.9
Adams, J.10
Rosenthal, A.S.11
Faanes, R.12
Eckner, R.J.13
Koup, R.A.14
Sullivan, J.L.15
-
14
-
-
0025740266
-
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones
-
Hargrave, K.D., Proudfoot, J.R., Grozinger, K.G., Cullen, E., Kapadia, S.R., Patel, U.R., Fuchs, V.U., Maudlin, S.C., Vitous, J., Behnke, M.L., Klunder, J.M., Pal, K., Skiles, J.W., McNeil, D.W., Rose, J.M., Chow, G.C., Skoog, M.T., Wu, J.C., Schmidt, G., Engel, W.W., Eberlein, W.G. and Saboe, T.D. Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones. J. Med. Chem. 1991, 34, 2231-2241
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2231-2241
-
-
Hargrave, K.D.1
Proudfoot, J.R.2
Grozinger, K.G.3
Cullen, E.4
Kapadia, S.R.5
Patel, U.R.6
Fuchs, V.U.7
Maudlin, S.C.8
Vitous, J.9
Behnke, M.L.10
Klunder, J.M.11
Pal, K.12
Skiles, J.W.13
McNeil, D.W.14
Rose, J.M.15
Chow, G.C.16
Skoog, M.T.17
Wu, J.C.18
Schmidt, G.19
Engel, W.W.20
Eberlein, W.G.21
Saboe, T.D.22
more..
-
15
-
-
0026003110
-
Pyridinone derivatives: Specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity
-
Goldman, M.E., Nunberg, J.H., O'Brien, J.A., Quintero, J.C., Schleif, W.A., Freund, K.F., Gaul, S.L., Saari, W.S., J.S. W.S., Hoffman, J.M., Anderson, P.S., Hupe, D.J., Emini, E.A. and Stern, A.M. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. Proc. Natl. Acad. Sci. USA 1991, 88, 6863-6867.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 6863-6867
-
-
Goldman, M.E.1
Nunberg, J.H.2
O'Brien, J.A.3
Quintero, J.C.4
Schleif, W.A.5
Freund, K.F.6
Gaul, S.L.7
Saari, W.S.8
Saari, J.S.9
Hoffman, J.M.10
Anderson, P.S.11
Hupe, D.J.12
Emini, E.A.13
Stern, A.M.14
-
16
-
-
0025996983
-
Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication
-
Romero, D.L., Busso, M., Tan, C.-K., Reusser, F., Palmer, J.R., Poppe, S.M., Aristoff P.A., Downey, K.M., So, A.G., Resnick, L., and Tarpley, W.G. Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication. Proc. Natl. Acad. Sci. USA 1991, 88, 8806-8810.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 8806-8810
-
-
Romero, D.L.1
Busso, M.2
Tan, C.-K.3
Reusser, F.4
Palmer, J.R.5
Poppe, S.M.6
Aristoff, P.A.7
Downey, K.M.8
So, A.G.9
Resnick, L.10
Tarpley, W.G.11
-
17
-
-
0027178052
-
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
-
Dueweke, T.J., Poppe, S.M., Romero, D.L., Swaney, S.M., So, A.G., Downey, K.M., Althaus, I.W., Reusser, F., Busso, M., Resnick, L., Mayers, D.L., Lane, J., Aristoff, P.A., Thomas, R.C., and Tarpley, W.G. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. 1993, 37, 1127-1131.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1127-1131
-
-
Dueweke, T.J.1
Poppe, S.M.2
Romero, D.L.3
Swaney, S.M.4
So, A.G.5
Downey, K.M.6
Althaus, I.W.7
Reusser, F.8
Busso, M.9
Resnick, L.10
Mayers, D.L.11
Lane, J.12
Aristoff, P.A.13
Thomas, R.C.14
Tarpley, W.G.15
-
18
-
-
0026650693
-
Synthesis of [1-[2′,5′-bis-O-(t-butyldimethylsilyl)-(β-D-xylo- and β-D-ribofuranosyl)thymine]-3′-spiro-5″-[4″ -amino-1″, 2″-oxathiole-2″,2″-dioxide]] (TSAO). A novel type of specific anti-HIV agents
-
Pérez-Pérez, M.-J., San-Félix, A., Camarasa, M.J., Balzarini, J. and De Clercq, E. Synthesis of [1-[2′,5′-bis-O-(t-butyldimethylsilyl)-(β-D-xylo- and β-D-ribofuranosyl)thymine]-3′-spiro-5″-[4″ -amino-1″, 2″-oxathiole-2″,2″-dioxide]] (TSAO). A novel type of specific anti-HIV agents. Tetrahedron Letters 1992, 33, 3029-3032.
-
(1992)
Tetrahedron Letters
, vol.33
, pp. 3029-3032
-
-
Pérez-Pérez, M.-J.1
San-Félix, A.2
Camarasa, M.J.3
Balzarini, J.4
De Clercq, E.5
-
19
-
-
0026771409
-
3′-Spironucleosides (TSAO derivatives), a new class of specific human immunodeficiency virus type 1 inhibitors. Synthesis and antiviral activity of 3′-spiro-5″-[4″-amino-1″,2″ -oxathiole-2″,2″-dioxide]pyrimidine nucleosides
-
Camarasa, M.-J., Pérez-Pérez, M.J., San-Félix, A., Balzarini, J. and De Clercq, E. 3′-Spironucleosides (TSAO derivatives), a new class of specific human immunodeficiency virus type 1 inhibitors. Synthesis and antiviral activity of 3′-spiro-5″-[4″-amino-1″,2″ -oxathiole-2″,2″-dioxide]pyrimidine nucleosides. J. Med. Chem. 1992, 35, 2721-2727.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2721-2727
-
-
Camarasa, M.-J.1
Pérez-Pérez, M.J.2
San-Félix, A.3
Balzarini, J.4
De Clercq, E.5
-
20
-
-
0026606044
-
2′,5′-Bis-O -(tert-butyldimethylsilyl)- 3′-spiro- 5″-(4″-amino-1″,2″-oxathiole-2″,2″ -dioxide)pyrimidine (TSAO) nucleoside analogues: Highly selective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase
-
Balzarini, J., Pérez-Pérez, M.-J., San-Félix, A., Schols, D., Perno, C.-F., Vandamme, A.-M., Camarasa, M.-J. and De Clercq, E. 2′,5′-Bis-O -(tert-butyldimethylsilyl)- 3′-spiro- 5″-(4″-amino-1″,2″-oxathiole-2″,2″ -dioxide)pyrimidine (TSAO) nucleoside analogues: highly selective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. Proc. Natl. Acad. Sci. USA 1992, 89, 4392-4396
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4392-4396
-
-
Balzarini, J.1
Pérez-Pérez, M.-J.2
San-Félix, A.3
Schols, D.4
Perno, C.-F.5
Vandamme, A.-M.6
Camarasa, M.-J.7
De Clercq, E.8
-
21
-
-
0027407551
-
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of α-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase
-
Pauwels, R., Andries, K., Debyser, Z., P. Van Daele, D. Schols, P. Stoffels, K. De Vreese, R. Woestenborghs, A.-M. Vandamme, C.G.M. Janssen, J. Anné, G. Cauwenbergh, J. Desmyter, J. Heykants, M.A.C. Janssen, E. De Clercq, and P.A.J. Janssen. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of α-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proc. Natl. Acad. Sci. USA 1993, 90, 1711-1715.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1711-1715
-
-
Pauwels, R.1
Andries, K.2
Debyser, Z.3
Van Daele, P.4
Schols, D.5
Stoffels, P.6
De Vreese, K.7
Woestenborghs, R.8
Vandamme, A.-M.9
Janssen, C.G.M.10
Anné, J.11
Cauwenbergh, G.12
Desmyter, J.13
Heykants, J.14
Janssen, M.A.C.15
De Clercq, E.16
Janssen, P.A.J.17
-
22
-
-
0028998825
-
The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase
-
Ahgren, C., Backro, K., Bell, F.W., Cantrell, A.S., Clemens, M., Colacino, J.M., Deeter, J.B., Engelhardt, J.A., Hogberg, M., Jaskunas, S.R., Johansson, N.G., Jordan, C.L., Kasher, J.S., Kinnick, M.D., Lind, P., Lopez, C., Morin J.M. Jr., Muesing, M.A., Noreen, R., Öberg, B., Paget, C.J., Palkowitz, J.A., Parrish, C.A., Pranc, P., Rippy, M.K., Rydergard, C., Sahlberg, C., Swanson, S., Ternasky, R.J., Unge, T., Vasileff, R.T., Vrang, L., West, S.J., Zhang, H. and Zhou, X.X. The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 1995, 39, 1329-1335.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1329-1335
-
-
Ahgren, C.1
Backro, K.2
Bell, F.W.3
Cantrell, A.S.4
Clemens, M.5
Colacino, J.M.6
Deeter, J.B.7
Engelhardt, J.A.8
Hogberg, M.9
Jaskunas, S.R.10
Johansson, N.G.11
Jordan, C.L.12
Kasher, J.S.13
Kinnick, M.D.14
Lind, P.15
Lopez, C.16
Morin Jr., J.M.17
Muesing, M.A.18
Noreen, R.19
Öberg, B.20
Paget, C.J.21
Palkowitz, J.A.22
Parrish, C.A.23
Pranc, P.24
Rippy, M.K.25
Rydergard, C.26
Sahlberg, C.27
Swanson, S.28
Ternasky, R.J.29
Unge, T.30
Vasileff, R.T.31
Vrang, L.32
West, S.J.33
Zhang, H.34
Zhou, X.X.35
more..
-
23
-
-
0028850110
-
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs
-
Bell, F.W., Cantrell, A.S., Högberg, M., Jaskunas, S.R., Johansson, N.G., Jordan, C.L., Kinnick, M.D., Lind, L., Morin J.M. Jr., Noréen, R., Öberg, B., Palkowitz, J.A., Parrish, C.A., Pranc, P., Sahlberg, C., Ternansky, R.J., Vasileff, R.T., Vrang, L., West, S.J., Zhang, H. and Zhou, X.-X. Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs. J. Med. Chem. 1995, 38, 4929-4936.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4929-4936
-
-
Bell, F.W.1
Cantrell, A.S.2
Högberg, M.3
Jaskunas, S.R.4
Johansson, N.G.5
Jordan, C.L.6
Kinnick, M.D.7
Lind, L.8
Morin Jr., J.M.9
Noréen, R.10
Öberg, B.11
Palkowitz, J.A.12
Parrish, C.A.13
Pranc, P.14
Sahlberg, C.15
Ternansky, R.J.16
Vasileff, R.T.17
Vrang, L.18
West, S.J.19
Zhang, H.20
Zhou, X.-X.21
more..
-
24
-
-
0028885715
-
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127
-
Zhang, H., Vrang, L., Backbro, K., Lind, P., Sahlberg, C., Unge, T., and Öberg, B. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127. Antiviral Res. 1995, 28, 331-342.
-
(1995)
Antiviral Res.
, vol.28
, pp. 331-342
-
-
Zhang, H.1
Vrang, L.2
Backbro, K.3
Lind, P.4
Sahlberg, C.5
Unge, T.6
Öberg, B.7
-
25
-
-
0037679871
-
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues
-
Högberg, M., Sahlberg, C., Engelhardt, P., Noréen, R., Kangasmetsä, J., Johansson, N.G., Öberg, B., Vrang, L., Zhang, H., Sahlberg, B.-L., Unge, T., Lövgren, S., Fridborg, K. and Bä ckbro, K. Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. J. Med. Chem. 1999, 42, 4150-4160.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4150-4160
-
-
Högberg, M.1
Sahlberg, C.2
Engelhardt, P.3
Noréen, R.4
Kangasmetsä, J.5
Johansson, N.G.6
Öberg, B.7
Vrang, L.8
Zhang, H.9
Sahlberg, B.-L.10
Unge, T.11
Lövgren, S.12
Fridborg, K.13
Bäckbro, K.14
-
26
-
-
0032537615
-
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Sahlberg, C., Noréen, R., Engelhardt, P., Högberg, M., Nangasmetsä, J., Vrang, L. and Zhang, H. Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. 1998, 8, 1511-1516.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 1511-1516
-
-
Sahlberg, C.1
Noréen, R.2
Engelhardt, P.3
Högberg, M.4
Nangasmetsä, J.5
Vrang, L.6
Zhang, H.7
-
27
-
-
0029809694
-
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus typ 1 (HIV-1) replication
-
Balzarini, J., Pelemans, H., Aquaro, S., Perno, C.-F., Witvrouw, M., Schols, D., De Clercq, E. and Karlsson, A. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus typ 1 (HIV-1) replication. Mol. Pharmacol. 1996, 50, 394-401.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 394-401
-
-
Balzarini, J.1
Pelemans, H.2
Aquaro, S.3
Perno, C.-F.4
Witvrouw, M.5
Schols, D.6
De Clercq, E.7
Karlsson, A.8
-
28
-
-
0028940526
-
Oxathiin carboxanilide derivatives: A class of non-nucleoside HIV-1-specific reverse transcriptase inhibitors (NNRTIs) that are active against mutant HIV-1 strains resistant to other NNRTIs
-
Balzarini, J., Jonckheere, H., Harrison, W.A., Dao, D.C., Anné, J., De Clercq, E. and Karlsson, A. Oxathiin carboxanilide derivatives: a class of non-nucleoside HIV-1-specific reverse transcriptase inhibitors (NNRTIs) that are active against mutant HIV-1 strains resistant to other NNRTIs. Antiviral Chem. Chemother. 1995, 6, 169-178.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 169-178
-
-
Balzarini, J.1
Jonckheere, H.2
Harrison, W.A.3
Dao, D.C.4
Anné, J.5
De Clercq, E.6
Karlsson, A.7
-
29
-
-
0028838466
-
Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide
-
Buckheit, R.W. Jr., Kinjerski, T.L., Fliakas-Boltz, V., Russell, J.D., Stup, T.L., Pallansch, L.A., Brouwer, W.G., Dao, D.C., Harrison, W.A., Schultz, R.J., Bader, J.P. and Yang, S.S. Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide. Antimicrob. Agents Chemother. 1995, 39, 2718-2727.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2718-2727
-
-
Buckheit Jr., R.W.1
Kinjerski, T.L.2
Fliakas-Boltz, V.3
Russell, J.D.4
Stup, T.L.5
Pallansch, L.A.6
Brouwer, W.G.7
Dao, D.C.8
Harrison, W.A.9
Schultz, R.J.10
Bader, J.P.11
Yang, S.S.12
-
30
-
-
8244226649
-
Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates
-
Buckheit, R.W. Jr., Snow, M.J., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D., Pallansch, L.A., Brouwer, W.G. and Yang, S.S. Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates. Antimicrob. Agents Chemother. 1997, 41, 831-837.
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 831-837
-
-
Buckheit Jr., R.W.1
Snow, M.J.2
Fliakas-Boltz, V.3
Kinjerski, T.L.4
Russell, J.D.5
Pallansch, L.A.6
Brouwer, W.G.7
Yang, S.S.8
-
31
-
-
0027273015
-
Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication
-
Kleim, J.-P., Bender, R., Billhardt, U.-M., Meichsner, C., Riess, G., Rösner, M., Winkler, I. and Paessens, A. Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication. Antimicrob. Agents Chemother. 1993, 37, 1659-1664.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1659-1664
-
-
Kleim, J.-P.1
Bender, R.2
Billhardt, U.-M.3
Meichsner, C.4
Riess, G.5
Rösner, M.6
Winkler, I.7
Paessens, A.8
-
32
-
-
0029147651
-
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
-
Kleim, J.-P., Bender, R., Kirsch, R., Meichsner, C., Paessens, A., Rösner, M., Rübsamen-Waigmann, H., Kaiser, R., Wichers, M., Schneweis, K.E., Winkler, I. and Riess, G. Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. 1995, 39, 2253-2257.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2253-2257
-
-
Kleim, J.-P.1
Bender, R.2
Kirsch, R.3
Meichsner, C.4
Paessens, A.5
Rösner, M.6
Rübsamen-Waigmann, H.7
Kaiser, R.8
Wichers, M.9
Schneweis, K.E.10
Winkler, I.11
Riess, G.12
-
33
-
-
0034630305
-
Long-term exposure of combinations of the novel quinoxaline GW420867X with lamivudine, abacavir and a variety of non-nucleoside reverse transcriptase inhibitors to HIV-1-infected cell cultures
-
in press
-
Balzarini, J., De Clercq, E., Carbonez, A., Burt, V. and Kleim, J.-P. Long-term exposure of combinations of the novel quinoxaline GW420867X with lamivudine, abacavir and a variety of non-nucleoside reverse transcriptase inhibitors to HIV-1-infected cell cultures AIDS Res. Hum. Retrovir 2000, in press.
-
(2000)
AIDS Res. Hum. Retrovir.
-
-
Balzarini, J.1
De Clercq, E.2
Carbonez, A.3
Burt, V.4
Kleim, J.-P.5
-
34
-
-
0027521797
-
3,4-Dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs): A new class of specific inhibitors of human immunodeficiency virus type 1
-
Artico, M., Massa, S., Mai, A., Marongiu, M.E., Piras, G., Tramontano, E. and La Colla,P. 3,4-Dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs): a new class of specific inhibitors of human immunodeficiency virus type 1. Antiviral Chem. Chemother. 1993, 4, 361-368.
-
(1993)
Antiviral Chem. Chemother.
, vol.4
, pp. 361-368
-
-
Artico, M.1
Massa, S.2
Mai, A.3
Marongiu, M.E.4
Piras, G.5
Tramontano, E.6
La Colla, P.7
-
35
-
-
0028869436
-
Synthesis and antiviral activity of new 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), specific inhibitors of human immunodeficiency virus type 1
-
Massa, S., Mai, A., Artico, M., Sbardella, G., Tramontano, E., Loi, A.G., Scano, P. and La Colla, P. Synthesis and antiviral activity of new 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), specific inhibitors of human immunodeficiency virus type 1. Antiviral Chem. Chemother. 1995, 6, 1-8.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 1-8
-
-
Massa, S.1
Mai, A.2
Artico, M.3
Sbardella, G.4
Tramontano, E.5
Loi, A.G.6
Scano, P.7
La Colla, P.8
-
36
-
-
0029095334
-
Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines
-
Mai A, Artico, M., Sbardella, G., Massa, S., Loi, A.G., Tramontano, E., Scano, P. and La Colla, P. Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines. J Med Chem. 1995, 38, 3258-3263
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3258-3263
-
-
Mai, A.1
Artico, M.2
Sbardella, G.3
Massa, S.4
Loi, A.G.5
Tramontano, E.6
Scano, P.7
La Colla, P.8
-
37
-
-
0031729622
-
Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent non-nucleoside inhibitors of the human immunodeficiency virus reverse transcriptase
-
Sudbeck E.A, Mao, C., Vig, R., Venkatachalam, T.K., Tuel-Ahlgren, L. and Uckun, F.M. Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent non-nucleoside inhibitors of the human immunodeficiency virus reverse transcriptase. Antimicrob. Agents Chemother. 1998, 42, 3225-3233.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 3225-3233
-
-
Sudbeck, E.A.1
Mao, C.2
Vig, R.3
Venkatachalam, T.K.4
Tuel-Ahlgren, L.5
Uckun, F.M.6
-
38
-
-
0027930721
-
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
-
Tucker, T.J., Lyle, T.A., Wiscount, C.M., Britcher, S.F., Young, S.D., Sanders, W.M., Lumma, W.C., Goldman, M.E., O'Brien, J.A., Ball, R.G., Homnick, C.F., Schleif, W.A., Emini, E.A., Huff, J.R. and Anderson, P.S. Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. J. Med. Chem. 1994, 37, 2437-2444.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2437-2444
-
-
Tucker, T.J.1
Lyle, T.A.2
Wiscount, C.M.3
Britcher, S.F.4
Young, S.D.5
Sanders, W.M.6
Lumma, W.C.7
Goldman, M.E.8
O'Brien, J.A.9
Ball, R.G.10
Homnick, C.F.11
Schleif, W.A.12
Emini, E.A.13
Huff, J.R.14
Anderson, P.S.15
-
39
-
-
0028785708
-
L-743,726 (DMP-266): A novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
-
Young, S.D., Britcher, S.F., Tran, L.O., Payne, L.S., Lumma, W.C., Lyle, T.A., Huff, J.R., Anderson, P.S., Olsen, D.B., Carroll, S.S., Pettibone, D.J., O'Brien, J.A., Ball, R.G., Balani, S.K., Lin, J.H., Chen, I.-W., Schleif, W.A., Sardana, V.V., Long, W.J., Byrnes, V.W. and Emini, E.A. L-743,726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents. Chemother. 1995, 39, 2602-2605.
-
(1995)
Antimicrob. Agents. Chemother.
, vol.39
, pp. 2602-2605
-
-
Young, S.D.1
Britcher, S.F.2
Tran, L.O.3
Payne, L.S.4
Lumma, W.C.5
Lyle, T.A.6
Huff, J.R.7
Anderson, P.S.8
Olsen, D.B.9
Carroll, S.S.10
Pettibone, D.J.11
O'Brien, J.A.12
Ball, R.G.13
Balani, S.K.14
Lin, J.H.15
Chen, I.-W.16
Schleif, W.A.17
Sardana, V.V.18
Long, W.J.19
Byrnes, V.W.20
Emini, E.A.21
more..
-
40
-
-
0028569182
-
Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones
-
Carroll, S.S., Stahlhut, M., Geib, J. and Olsen, D.B. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. J. Biol. Chem. 1994, 269, 32351-32357.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 32351-32357
-
-
Carroll, S.S.1
Stahlhut, M.2
Geib, J.3
Olsen, D.B.4
-
41
-
-
0034618157
-
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors
-
Patel, M., McHugh R.J. Jr., Cordova, B.C., Klabe, R.M., Erickson-Viitanen, S., Trainor, G.L. and Rodgers, J.D. Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. 2000, 10, 1729-1731.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 1729-1731
-
-
Patel, M.1
McHugh Jr., R.J.2
Cordova, B.C.3
Klabe, R.M.4
Erickson-Viitanen, S.5
Trainor, G.L.6
Rodgers, J.D.7
-
42
-
-
0035806181
-
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors
-
Cocuzza, A.J., Chidester, D.R., Cordova, B.C., Klabe, R.M., Jeffrey, S., Diamond, S., Weigelt, C.A., Ko, S.S., Bacheler, L.T., Erickson-Viitanen, S.K. and Rodgers, J.D. 4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. 2001, 11, 1389-1392.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 1389-1392
-
-
Cocuzza, A.J.1
Chidester, D.R.2
Cordova, B.C.3
Klabe, R.M.4
Jeffrey, S.5
Diamond, S.6
Weigelt, C.A.7
Ko, S.S.8
Bacheler, L.T.9
Erickson-Viitanen, S.K.10
Rodgers, J.D.11
-
43
-
-
3042777884
-
-
DuPont Pharmaceuticals Co, USA. PCT Int. Appl, WO 000 00, 479 (CI. CO7D243/04)
-
Rodgers, J.D., Cocuzza, A.J. 2000. DuPont Pharmaceuticals Co, USA. PCT Int. Appl, WO 000 00, 479 (CI. CO7D243/04).
-
(2000)
-
-
Rodgers, J.D.1
Cocuzza, A.J.2
-
44
-
-
0032786364
-
Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1
-
Corbett, J.W., Ko, S.S., Rodgers, J.D., Jeffrey, S., Bacheler, L.T., Klabe, R.M., Diamond, S., Lai, C.M., Rabel, S.R., Saye, J.A., Adams, S.P., Trainor, G.L., Anderson, P.S., Erickson- Viitanen, S.K. Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 1999, 43, 2893-2897.
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 2893-2897
-
-
Corbett, J.W.1
Ko, S.S.2
Rodgers, J.D.3
Jeffrey, S.4
Bacheler, L.T.5
Klabe, R.M.6
Diamond, S.7
Lai, C.M.8
Rabel, S.R.9
Saye, J.A.10
Adams, S.P.11
Trainor, G.L.12
Anderson, P.S.13
Erickson- Viitanen, S.K.14
-
45
-
-
0027156955
-
Thiazolobenzimidazole: Biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor
-
Buckheit, R.W. Jr., Hollingshead, M.G., Germany-Decker, J., White, E.L., McMahon, J.B., Allen, L.B., Ross, L.J., Decker, W.D., Westbrook, L., Shannon, W.M., Weislow, O., Bader, J.P. and Boyd, M.R. Thiazolobenzimidazole: biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 1993, 21, 247-265.
-
(1993)
Antiviral Res.
, vol.21
, pp. 247-265
-
-
Buckheit Jr., R.W.1
Hollingshead, M.G.2
Germany-Decker, J.3
White, E.L.4
McMahon, J.B.5
Allen, L.B.6
Ross, L.J.7
Decker, W.D.8
Westbrook, L.9
Shannon, W.M.10
Weislow, O.11
Bader, J.P.12
Boyd, M.R.13
-
46
-
-
0030814399
-
Structural features and anti-human immunodeficiency virus (HIV) activity of the isomers of 1-(2′,6′-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor
-
Chimirri, A., Grasso, S., Molica, C., Monforte, A.-M., Monforte, P., Zappalà, M., Bruno, G., Nicolò, F., Witvrouw, M., Jonckheere, H., Balzarini, J. and De Clercq, E. Structural features and anti-human immunodeficiency virus (HIV) activity of the isomers of 1-(2′,6′-difluorophenyl -1H,3H-thiazolo[3,4-a]benzimidazole, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral Chem. Chemother. 1997, 8, 363-370.
-
(1997)
Antiviral Chem. Chemother.
, vol.8
, pp. 363-370
-
-
Chimirri, A.1
Grasso, S.2
Molica, C.3
Monforte, A.-M.4
Monforte, P.5
Zappalà, M.6
Bruno, G.7
Nicolò, F.8
Witvrouw, M.9
Jonckheere, H.10
Balzarini, J.11
De Clercq, E.12
-
47
-
-
0027376921
-
Viral resistance to the thiazolo-iso-indolinones, a new class of nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase
-
Maass, G., Immendoerfer, U., Koenig, B., Leser, U., Mueller, B., Goody, R. and Pfaff, E. Viral resistance to the thiazolo-iso-indolinones, a new class of nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 1993, 37, 2612-2617.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 2612-2617
-
-
Maass, G.1
Immendoerfer, U.2
Koenig, B.3
Leser, U.4
Mueller, B.5
Goody, R.6
Pfaff, E.7
-
48
-
-
0027257652
-
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo [2,3-a]isoindol-5(9H)-ones and related compounds with anti-HIV-1 activity
-
Mertens, A., Zilch, H., Konig, B., Schafer, W., Poll, T., Kampe, W., Seidel, H., Leser, U. and Leinert, H. Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo [2,3-a]isoindol-5(9H)-ones and related compounds with anti-HIV-1 activity. J. Med. Chem. 1993, 36, 2526-2535.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 2526-2535
-
-
Mertens, A.1
Zilch, H.2
Konig, B.3
Schafer, W.4
Poll, T.5
Kampe, W.6
Seidel, H.7
Leser, U.8
Leinert, H.9
-
49
-
-
14444278270
-
Pyrimidine thioethers: A novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV
-
Nugent, R.A., Schlachter, S.T., Murphy, M.J., Cleek, G.J., Poel, T.J., Wishka, D.G., Graber, D.R., Yagi, Y., Keiser, B.J., Olmsted, R.A., Kopta, L.A., Swaney, S.M., Poppe, S.M., Morris, J., Tarpley, W.G. and Thomas, R.C. Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J. Med. Chem. 1998, 41, 3793-3803.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3793-3803
-
-
Nugent, R.A.1
Schlachter, S.T.2
Murphy, M.J.3
Cleek, G.J.4
Poel, T.J.5
Wishka, D.G.6
Graber, D.R.7
Yagi, Y.8
Keiser, B.J.9
Olmsted, R.A.10
Kopta, L.A.11
Swaney, S.M.12
Poppe, S.M.13
Morris, J.14
Tarpley, W.G.15
Thomas, R.C.16
-
50
-
-
0032560237
-
(-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor
-
Wishka, D.G., Graber, D.R., Kopta, L.A., Olmsted, R.A., Friis, J.M., Hosley, J.D., Adams, W.J., Seest, E.P., Castle, T.M., Dolak, L.A., Keiser, B.J., Yagi, Y., Jeganathan, A., Schlachter, S.T., Murphy, M.J., Cleek, G.J., Nugent, R.A., Poppe, S.M., Swaney, S.M., Han, F., Watt, W., White, W.L., Poel, T.-J., Thomas, R.C., Voorman, R.L., Stefanski, K.J., Stehle, R.G., Tarpley, W.G. and Morris, J. (-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor. J. Med. Chem. 1998, 41, 1357-1360.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1357-1360
-
-
Wishka, D.G.1
Graber, D.R.2
Kopta, L.A.3
Olmsted, R.A.4
Friis, J.M.5
Hosley, J.D.6
Adams, W.J.7
Seest, E.P.8
Castle, T.M.9
Dolak, L.A.10
Keiser, B.J.11
Yagi, Y.12
Jeganathan, A.13
Schlachter, S.T.14
Murphy, M.J.15
Cleek, G.J.16
Nugent, R.A.17
Poppe, S.M.18
Swaney, S.M.19
Han, F.20
Watt, W.21
White, W.L.22
Poel, T.-J.23
Thomas, R.C.24
Voorman, R.L.25
Stefanski, K.J.26
Stehle, R.G.27
Tarpley, W.G.28
Morris, J.29
more..
-
51
-
-
0032497648
-
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit the human immunodeficiency virus type 1 (HIV-1) replication
-
in press
-
Arranz, E., Díaz, J.A., Ingate, S.T., Witvrouw, M., Pannecouque, C., Balzarini, J., De Clercq, E. and Vega, S. Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit the human immunodeficiency virus type 1 (HIV-1) replication. J. Med. Chem. 1998, in press.
-
(1998)
J. Med. Chem.
-
-
Arranz, E.1
Díaz, J.A.2
Ingate, S.T.3
Witvrouw, M.4
Pannecouque, C.5
Balzarini, J.6
De Clercq, E.7
Vega, S.8
-
52
-
-
0031938084
-
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: A new class of nonnucleoside human immuno-deficiency virus type 1 (HIV-1) reverse transcriptase inhibitors (NNRTIs) with anti-HIV-1 activity
-
Witvrouw, M., Arranz, M.E., Pannecouque, C., Declercq, R., Jonckheere, H., Schmit, J.-C., Vandamme, A.M., Diaz, J.A., Ingate, S.T., Desmyter, J., Esnouf, R., Van Meervelt, L., Vega, S., Balzarini, J. and De Clercq, E. 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immuno-deficiency virus type 1 (HIV-1) reverse transcriptase inhibitors (NNRTIs) with anti-HIV-1 activity. Antimicrob. Agents Chemo-ther. 1998, 42, 618-623.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 618-623
-
-
Witvrouw, M.1
Arranz, M.E.2
Pannecouque, C.3
Declercq, R.4
Jonckheere, H.5
Schmit, J.-C.6
Vandamme, A.M.7
Diaz, J.A.8
Ingate, S.T.9
Desmyter, J.10
Esnouf, R.11
Van Meervelt, L.12
Vega, S.13
Balzarini, J.14
De Clercq, E.15
-
53
-
-
0029123985
-
Potent and specific inhibition of human immunodeficiency virus type 1 replication by 4-(2,6-dichloro-phenyl)1,2,5-thiadiazol-3-Y1 N,N-dialkylcarbamate derivatives
-
Ijichi, K., Fujiwara, M., Hanasaki, Y., Watanabe, H., Katsuura, K., Takayama, H., Shirakawa, S., Sakai, S.-I., Shigeta, S., Konno, K., Yokota, T. and Baba, M. Potent and specific inhibition of human immunodeficiency virus type 1 replication by 4-(2,6-dichloro-phenyl)1,2,5-thiadiazol-3-Y1 N,N-dialkylcarbamate derivatives. Antimicrob. Agents Chemother. 1995, 39, 2337-2340.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2337-2340
-
-
Ijichi, K.1
Fujiwara, M.2
Hanasaki, Y.3
Watanabe, H.4
Katsuura, K.5
Takayama, H.6
Shirakawa, S.7
Sakai, S.-I.8
Shigeta, S.9
Konno, K.10
Yokota, T.11
Baba, M.12
-
54
-
-
19244377980
-
Anti-HIV-1 activity of thiadiazole derivatives: A structure-activity relationship, reverse transcriptase inhibition, and lipophilicity
-
Ijichi, K., M. Fujiwara, H. Nagano, Y, Matsumoto, Y. Hanasaki, T. Ide, K. Katsuura, H. Takayama, S. Shirakawa, N. Aimi, S. Shigeta, K. Konno, M. Matsushima, T. Yokota, and M. Baba. Anti-HIV-1 activity of thiadiazole derivatives: a structure-activity relationship, reverse transcriptase inhibition, and lipophilicity. Antiviral Res. 1996,31, 87-94.
-
(1996)
Antiviral Res.
, vol.31
, pp. 87-94
-
-
Ijichi, K.1
Fujiwara, M.2
Nagano, H.3
Matsumoto, Y.4
Hanasaki, Y.5
Ide, T.6
Katsuura, K.7
Takayama, H.8
Shirakawa, S.9
Aimi, N.10
Shigeta, S.11
Konno, K.12
Matsushima, M.13
Yokota, T.14
Baba, M.15
-
55
-
-
0030976265
-
Thiadiazole derivatives: Highly potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replications in vitro
-
Fujiwara, M., Ijichi, K., Hanasaki, Y., Ide, T., Katsuura, K., Takayama, H., Aimi, N., Shigeta, S., Konno, K., Yokota, T., Baba, M. Thiadiazole derivatives: highly potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replications in vitro. Microbiol. Immunol. 1997, 41, 301-308.
-
(1997)
Microbiol. Immunol.
, vol.41
, pp. 301-308
-
-
Fujiwara, M.1
Ijichi, K.2
Hanasaki, Y.3
Ide, T.4
Katsuura, K.5
Takayama, H.6
Aimi, N.7
Shigeta, S.8
Konno, K.9
Yokota, T.10
Baba, M.11
-
56
-
-
0029060789
-
Thiadiazole derivatives: Highly potent and specific HIV-1 reverse transcriptase inhibitors
-
Hanasaki, Y., Watanabe, H., Katsuura, K., Takayama, H., Shirakawa, S. Yamaguchi, K., Sakai, S., Ijichi, K., Fujiwara, M., Konno, K., Yokota, T., Shigeta, S. and Baba, M. Thiadiazole derivatives: highly potent and specific HIV-1 reverse transcriptase inhibitors. J. Med. Chem. 1995, 38, 2038-2040.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2038-2040
-
-
Hanasaki, Y.1
Watanabe, H.2
Katsuura, K.3
Takayama, H.4
Shirakawa, S.5
Yamaguchi, K.6
Sakai, S.7
Ijichi, K.8
Fujiwara, M.9
Konno, K.10
Yokota, T.11
Shigeta, S.12
Baba, M.13
-
57
-
-
0032757544
-
Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217
-
Fujiwara, M., Kodama, E.N., Okamoto, M., Tokuhisa, K., Teruhiko, I., Hanasaki, Y., Katsuura, K., Takayama, H., Aimi, N., Mitsuya, H., Shigeta, S., Konno, K., Yokota, T. and Baba, M. Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217. Antiviral Chem. Chemother. 1999, 10, 315-230.
-
(1999)
Antiviral Chem. Chemother.
, vol.10
, pp. 230-315
-
-
Fujiwara, M.1
Kodama, E.N.2
Okamoto, M.3
Tokuhisa, K.4
Teruhiko, I.5
Hanasaki, Y.6
Katsuura, K.7
Takayama, H.8
Aimi, N.9
Mitsuya, H.10
Shigeta, S.11
Konno, K.12
Yokota, T.13
Baba, M.14
-
58
-
-
0027447592
-
Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob
-
McMahon, J.B., Gulakowski, R.J., Weislow, O.S., Schultz, R.J., V.L. Narayanan, D.J. Clanton, R. Pedemonte, F.W. Wassmundt, Buckheit R.W. Jr., Decker, W.D., White, E.L., Bader, J.P. and Boyd, M.R. Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 1993, 37, 754-760.
-
(1993)
Agents Chemother.
, vol.37
, pp. 754-760
-
-
McMahon, J.B.1
Gulakowski, R.J.2
Weislow, O.S.3
Schultz, R.J.4
Narayanan, V.L.5
Clanton, D.J.6
Pedemonte, R.7
Wassmundt, F.W.8
Buckheit Jr., R.W.9
Decker, W.D.10
White, E.L.11
Bader, J.P.12
Boyd, M.R.13
-
59
-
-
9544251506
-
A diarylsulphone non-nucleoside reverse transcriptase inhibitor with a unique sensitivity profile to drug-resistant virus isolates
-
Buckheit, R.W. Jr., Fliakas-Boltz, V., Russel, J.D., Snow, M., Pallansch, L.A., Yang, S.S., Bader, J.P., Khan, T.N. and Zanger, M. A diarylsulphone non-nucleoside reverse transcriptase inhibitor with a unique sensitivity profile to drug-resistant virus isolates. Antiviral Chem. Chemother. 1996, 7, 243-252.
-
(1996)
Antiviral Chem. Chemother.
, vol.7
, pp. 243-252
-
-
Buckheit Jr., R.W.1
Fliakas-Boltz, V.2
Russel, J.D.3
Snow, M.4
Pallansch, L.A.5
Yang, S.S.6
Bader, J.P.7
Khan, T.N.8
Zanger, M.9
-
60
-
-
0030045677
-
2-Sulfonyl-4-chloroanilino moiety: A potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones
-
Artico, M., Silvestri, R., Massa, S., Loi, A.G., Corrias, S., Piras, G., and La Colla, P. 2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones. J. Med. Chem. 1996, 39, 522-530.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 522-530
-
-
Artico, M.1
Silvestri, R.2
Massa, S.3
Loi, A.G.4
Corrias, S.5
Piras, G.6
La Colla, P.7
-
61
-
-
0034075488
-
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations
-
Artico, M., Silvestri, R., Pagnozzi, E., Bruno, B., Novellino, E., Greco, G., Massa, S., Ettorre, A., Loi, A.G., Scintu, F. and La Colla, P. Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations. J. Med. Chem. 2000, 43, 1886-1891.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1886-1891
-
-
Artico, M.1
Silvestri, R.2
Pagnozzi, E.3
Bruno, B.4
Novellino, E.5
Greco, G.6
Massa, S.7
Ettorre, A.8
Loi, A.G.9
Scintu, F.10
La Colla, P.11
-
62
-
-
0029783936
-
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors
-
Cushman, M., Golebiewski, W.M., Graham, L., Turpin, J.A., Rice, W.G., Fliakas-Boltz, V. and Buckheit R.W. Jr. Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 1996, 39, 3217-3227.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3217-3227
-
-
Cushman, M.1
Golebiewski, W.M.2
Graham, L.3
Turpin, J.A.4
Rice, W.G.5
Fliakas-Boltz, V.6
Buckheit Jr., R.W.7
-
63
-
-
0032482316
-
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors
-
Cushman, M., Casimiro-Garcia, A., Hejchman, E., Ruell, J.A., Huang, M., Schaeffer, C.A., Williamson, K., Rice, W.G. and Buckheit, R.W. Jr. New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 1998, 41, 2076-2089.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2076-2089
-
-
Cushman, M.1
Casimiro-Garcia, A.2
Hejchman, E.3
Ruell, J.A.4
Huang, M.5
Schaeffer, C.A.6
Williamson, K.7
Rice, W.G.8
Buckheit Jr., R.W.9
-
64
-
-
0032744956
-
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors
-
Casimiro-Garcia, A., Micklatcher, M., Turpin, J.A., Stup, T.L., Watson, K., Buckheit, R.W. and Cushman, M. Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 1999, 42, 4861-4874.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4861-4874
-
-
Casimiro-Garcia, A.1
Micklatcher, M.2
Turpin, J.A.3
Stup, T.L.4
Watson, K.5
Buckheit, R.W.6
Cushman, M.7
-
65
-
-
0035935730
-
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors
-
Xu, G., Micklatcher, M., Silvestri, M.A., Hartman, T.L., Burrier, J., Osterling, M.C., Wargo, H., Turpin, J.A., Buckheit R.W. Jr., and Cushman, M. The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 2001, 44, 4092-4113.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 4092-4113
-
-
Xu, G.1
Micklatcher, M.2
Silvestri, M.A.3
Hartman, T.L.4
Burrier, J.5
Osterling, M.C.6
Wargo, H.7
Turpin, J.A.8
Buckheit Jr., R.W.9
Cushman, M.10
-
66
-
-
0026647540
-
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum
-
Kashman, Y., Gustafson, K.R., Fuller, R.W., Cardellina J.H. II, McMahon, J.B., Currens, M.J., Buckheit R.W. Jr., Hughes, S.H., Cragg, G.M. and Boyd, M.R. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. J. Med. Chem. 1992, 35, 2735-2743.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2735-2743
-
-
Kashman, Y.1
Gustafson, K.R.2
Fuller, R.W.3
Cardellina II, J.H.4
McMahon, J.B.5
Currens, M.J.6
Buckheit Jr., R.W.7
Hughes, S.H.8
Cragg, G.M.9
Boyd, M.R.10
-
67
-
-
0030892239
-
Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10, 11-dimethyldihydropyran-12-ol ring (ring C)
-
Zembower, D.E., Liao, S., Flavin, M.T., Xu, Z.-Q., Stup, T.L., Buckheit R.W. Jr., Khilevich, A., Mar, A.A. and Sheinkman, A.K. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10, 11-dimethyldihydropyran-12-ol ring (ring C). J. Med. Chem. 1997, 40, 1005-1017.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1005-1017
-
-
Zembower, D.E.1
Liao, S.2
Flavin, M.T.3
Xu, Z.-Q.4
Stup, T.L.5
Buckheit Jr., R.W.6
Khilevich, A.7
Mar, A.A.8
Sheinkman, A.K.9
-
68
-
-
13344277278
-
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers
-
Flavin, M.T., Rizzo, J.D., Khilevich, A., Kucherenko, A., Sheinkman, A.K., Vilaychack, V., Lin, L., Chen, W., Greenwood, E.M., Pengsuparp, P., Pezzuto, J.M., Hughes, S.H., Flavin, T.M., Cibulski, M., Boulanger, W.A., Shone, R.L. and Xu, Z.-X. Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers. J. Med. Chem. 1996, 39, 1303-1313.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1303-1313
-
-
Flavin, M.T.1
Rizzo, J.D.2
Khilevich, A.3
Kucherenko, A.4
Sheinkman, A.K.5
Vilaychack, V.6
Lin, L.7
Chen, W.8
Greenwood, E.M.9
Pengsuparp, P.10
Pezzuto, J.M.11
Hughes, S.H.12
Flavin, T.M.13
Cibulski, M.14
Boulanger, W.A.15
Shone, R.L.16
Xu, Z.-X.17
-
69
-
-
0027725169
-
The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn
-
Patil, A.D., Freyer, A.J., Eggleston, D.S., Haltiwanger, R.C., Bean, M.F., Taylor, P.B., Caranfa, M.J., Breen, A.L., Bartus, H.R., Johnson, R.K., Hertzberg, R.P. and Westley, J.W. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J. Med. Chem. 1993, 36, 4131-4138.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 4131-4138
-
-
Patil, A.D.1
Freyer, A.J.2
Eggleston, D.S.3
Haltiwanger, R.C.4
Bean, M.F.5
Taylor, P.B.6
Caranfa, M.J.7
Breen, A.L.8
Bartus, H.R.9
Johnson, R.K.10
Hertzberg, R.P.11
Westley, J.W.12
-
70
-
-
0344172806
-
Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide
-
Buckheit, R.W. Jr., White, E.L., Fliakas-Boltz, V., Russell, J., Stup, T.L., Kinjerski, T.L., Osterling, M.C., Weigand, A. and Bader, J.P. Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide. Antimicrob. Agents Chemother. 1999, 43, 1827-1834.
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 1827-1834
-
-
Buckheit Jr., R.W.1
White, E.L.2
Fliakas-Boltz, V.3
Russell, J.4
Stup, T.L.5
Kinjerski, T.L.6
Osterling, M.C.7
Weigand, A.8
Bader, J.P.9
-
71
-
-
17944366732
-
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues
-
Ludovici, D.W., Kavash, R.W., Kukla, M.J., Ho, C.Y., Ye, H., De Corte, B.L., Andries, K., de Bethune, M.P., Azijn, H., Pauwels, R., Moereels, H.E., Heeres, J., Koymans, L.M., de Jonge, M.R., Van Aken, K.J., Daeyaert, F.F., Lewi, P.J., Das, K., Arnold, E. and Janssen, P.A. Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. Bioorg. Med. Chem. Lett. 2001, 11, 2229-2234.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2229-2234
-
-
Ludovici, D.W.1
Kavash, R.W.2
Kukla, M.J.3
Ho, C.Y.4
Ye, H.5
De Corte, B.L.6
Andries, K.7
de Bethune, M.P.8
Azijn, H.9
Pauwels, R.10
Moereels, H.E.11
Heeres, J.12
Koymans, L.M.13
de Jonge, M.R.14
Van Aken, K.J.15
Daeyaert, F.F.16
Lewi, P.J.17
Das, K.18
Arnold, E.19
Janssen, P.A.20
more..
-
72
-
-
0031805095
-
S-1153 inhibits replication of known rug-resistant strains of human immunodeficiency virus type 1
-
Fujiwara, T., Sato, A., El-Farrash, M., Miki, S., Abe, K., Isaka, Y., Kodama, M., Wu, Y., Chen, L.B., Harada, H., Sugimoto, H., Hatanaka, M. and Hinuma, Y. S-1153 inhibits replication of known rug-resistant strains of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 1998, 42, 1340-1345.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 1340-1345
-
-
Fujiwara, T.1
Sato, A.2
El-Farrash, M.3
Miki, S.4
Abe, K.5
Isaka, Y.6
Kodama, M.7
Wu, Y.8
Chen, L.B.9
Harada, H.10
Sugimoto, H.11
Hatanaka, M.12
Hinuma, Y.13
-
73
-
-
0027195714
-
5-Chloro-3-(phenylsulfonyl) indole-2-carboxamide: A novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase
-
Williams, T.M., Ciccarone, T.M., MacTough, S.C., Rooney, C.S., Balani, S.K., Condra, J.H., Emini, E.A., Goldman, M.E., Greenlee, W.J., Kauffman, L.R., O'Brien, J.A., Sardana, V.V., Schleif, W.A., Theoharides, A.D. and Anderson, P.S. 5-Chloro-3-(phenylsulfonyl) indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase. J. Med. Chem. 1993, 36, 1291-1294.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 1291-1294
-
-
Williams, T.M.1
Ciccarone, T.M.2
MacTough, S.C.3
Rooney, C.S.4
Balani, S.K.5
Condra, J.H.6
Emini, E.A.7
Goldman, M.E.8
Greenlee, W.J.9
Kauffman, L.R.10
O'Brien, J.A.11
Sardana, V.V.12
Schleif, W.A.13
Theoharides, A.D.14
Anderson, P.S.15
-
74
-
-
0028043362
-
Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors
-
Buckheit, R.W. Jr., Fliakas-Boltz, V., Decker, W.D., Roberson, J.L., Pyle, C.A., White, E.L., Bowdon, B.J., McMahon, J.B., Boyd, M.R., Bader, J.P., Nickel, D.G., Bart, H. and Antonucci, T.K. Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors. Antiviral Res. 1996, 25, 43-56.
-
(1996)
Antiviral Res.
, vol.25
, pp. 43-56
-
-
Buckheit Jr., R.W.1
Fliakas-Boltz, V.2
Decker, W.D.3
Roberson, J.L.4
Pyle, C.A.5
White, E.L.6
Bowdon, B.J.7
McMahon, J.B.8
Boyd, M.R.9
Bader, J.P.10
Nickel, D.G.11
Bart, H.12
Antonucci, T.K.13
-
75
-
-
0026715578
-
Imidazo[2′,3′:6,5 ] dipyrido[3,2- b: 2′,3′-e]-1, 4-diazepines: Nonnucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine
-
Terrett, N.K., Bojanic, D., Merson, J.R. and Stephenson, P.T. Imidazo[2′,3′:6,5 ] dipyrido[3,2- b: 2′,3′-e]-1, 4-diazepines: nonnucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine. Bioorg. Med. Chem. Lett. 1992, 2, 1745-1750.
-
(1992)
Bioorg. Med. Chem. Lett.
, vol.2
, pp. 1745-1750
-
-
Terrett, N.K.1
Bojanic, D.2
Merson, J.R.3
Stephenson, P.T.4
-
76
-
-
0027137488
-
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines
-
Livermore, D.G.H., Bethell, R.C., Cammack, N., Hancock, A.P., Hann, M.M., Green, D.V.S., Lamont, R.B., Noble, S.A., Orr, D.C., Payne, J.J., Ramsay, M.V.J., Shingler, A.H., Smith, C., Storer, R., Williamson, C. and Willson, T. Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines. J. Med. Chem. 1993, 36, 3784-3794.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 3784-3794
-
-
Livermore, D.G.H.1
Bethell, R.C.2
Cammack, N.3
Hancock, A.P.4
Hann, M.M.5
Green, D.V.S.6
Lamont, R.B.7
Noble, S.A.8
Orr, D.C.9
Payne, J.J.10
Ramsay, M.V.J.11
Shingler, A.H.12
Smith, C.13
Storer, R.14
Williamson, C.15
Willson, T.16
-
77
-
-
0029893162
-
New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase
-
Bellarosa, D., Antonelli, G., Bambacioni, F., Giannotti, D., Viti, G., Nannicini, R., Giachetti, A., Dianzani, F., Witvrouw, M., Pauwels, R., Desmyter, J. and De Clercq, E. New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase. Antiviral Res. 1996, 30, 109-124.
-
(1996)
Antiviral Res.
, vol.30
, pp. 109-124
-
-
Bellarosa, D.1
Antonelli, G.2
Bambacioni, F.3
Giannotti, D.4
Viti, G.5
Nannicini, R.6
Giachetti, A.7
Dianzani, F.8
Witvrouw, M.9
Pauwels, R.10
Desmyter, J.11
De Clercq, E.12
-
78
-
-
0029981307
-
The benzylthiopyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase
-
Althaus, I.W., Chou, K.-C., Lemay, R.J., Franks, K.M., Deibel, M.R., Kezdy, F.J., Resnick, L., Busso, M.E., So, A.G., Downey, K.M., Romero, D.L., Thomas, R.C., Aristoff, P.A., Tarpley, W.G. and Reusser, F. The benzylthiopyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase. Biochem. Pharmacol. 1996, 51, 743-750.
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 743-750
-
-
Althaus, I.W.1
Chou, K.-C.2
Lemay, R.J.3
Franks, K.M.4
Deibel, M.R.5
Kezdy, F.J.6
Resnick, L.7
Busso, M.E.8
So, A.G.9
Downey, K.M.10
Romero, D.L.11
Thomas, R.C.12
Aristoff, P.A.13
Tarpley, W.G.14
Reusser, F.15
-
79
-
-
0028877325
-
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors
-
Dollé, V., Nguyen, C.H., Aubertin, A.M., Kirn, A., Andreola, M.L., Jamieson, G., Tarrago-Litvak, L. and Bisagni, E. A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. J. Med. Chem. 1995, 38, 4679-4686.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4679-4686
-
-
Dollé, V.1
Nguyen, C.H.2
Aubertin, A.M.3
Kirn, A.4
Andreola, M.L.5
Jamieson, G.6
Tarrago-Litvak, L.7
Bisagni, E.8
-
80
-
-
0031049742
-
Design, synthesis and antiviral activity of new pyridinone derivatives
-
Jourdan, F., Renault, J., Fossey, C., Bureau, R., Ladurée, D., Robba, M., Aubertin, A.M. and Kirn, A. Design, synthesis and antiviral activity of new pyridinone derivatives. Antiviral Chem. Chemother. 1997, 8, 161-172.
-
(1997)
Antiviral Chem. Chemother.
, vol.8
, pp. 161-172
-
-
Jourdan, F.1
Renault, J.2
Fossey, C.3
Bureau, R.4
Ladurée, D.5
Robba, M.6
Aubertin, A.M.7
Kirn, A.8
-
81
-
-
0030759473
-
Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils
-
Kim, D.-K., Gam, J., Kim, Y.-W., Lim, J., Kim, H.-T. and Kim, K.H. Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils. J. Med. Chem. 1997, 40, 2363-2373.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2363-2373
-
-
Kim, D.-K.1
Gam, J.2
Kim, Y.-W.3
Lim, J.4
Kim, H.-T.5
Kim, K.H.6
-
82
-
-
0030814171
-
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones
-
Kelly, T.A., McNeil, D.W., Rose, J.M., David, E., Shih, C.-K. and Grob, P.M. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones. J. Med. Chem. 1997, 40, 2430-2433.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2430-2433
-
-
Kelly, T.A.1
McNeil, D.W.2
Rose, J.M.3
David, E.4
Shih, C.-K.5
Grob, P.M.6
-
83
-
-
0030011406
-
Pyrrolo-benzothiazepinones and pyrrolobenzoxazepinones: Novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity
-
Campiani, G., Nacci, V., Fiorini, I., De Filippis, M.P., Garofalo, A., Greco, G., Novellino, E., Altamura, S. and Di Renzo, L. Pyrrolo-benzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity. J. Med. Chem. 1996, 39, 2672-2680.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2672-2680
-
-
Campiani, G.1
Nacci, V.2
Fiorini, I.3
De Filippis, M.P.4
Garofalo, A.5
Greco, G.6
Novellino, E.7
Altamura, S.8
Di Renzo, L.9
-
84
-
-
0028932873
-
Characterization of the antiviral activity of highly substituted pyrroles: A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitor
-
Antonucci, T., Warmus, J.S., Hodges, J.C. and Nickell, D.G. Characterization of the antiviral activity of highly substituted pyrroles: a novel class of non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral Chem. Chemother. 1995, 6, 98-108.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 98-108
-
-
Antonucci, T.1
Warmus, J.S.2
Hodges, J.C.3
Nickell, D.G.4
-
85
-
-
10544230205
-
v.Pyridazino[3,4-b][1,5]benzoxazepin-5(6H)-ones: Synthesis and biological evaluation
-
Barth, B., Dierich, M., Heinisch, G., Jenny, V., Matuszczak, B., Mereiter, K., Planer, R., Schöpf, I., Stoiber, H., Traugott, T. and Aufschnaiter,P. v.Pyridazino[3,4-b][1,5]benzoxazepin-5(6H)-ones: synthesis and biological evaluation. Antiviral Chem. Chemother. 1996, 7, 300-312.
-
(1996)
Antiviral Chem. Chemother.
, vol.7
, pp. 300-312
-
-
Barth, B.1
Dierich, M.2
Heinisch, G.3
Jenny, V.4
Matuszczak, B.5
Mereiter, K.6
Planer, R.7
Schöpf, I.8
Stoiber, H.9
Traugott, T.10
Aufschnaiter, P.11
-
86
-
-
0003502490
-
Synthesis and biological evaluation of imidazo[1,2-d][1,4] benzodiazepines and related compounds as potential anti-HIV-1 agents
-
Krikorian, D., Parushev, S., Tarpanov, V., Mechkarova, P., Mikhova, B., Botta, M., Corelli, F., Maga, G. and Spadari, S. Synthesis and biological evaluation of imidazo[1,2-d][1,4] benzodiazepines and related compounds as potential anti-HIV-1 agents. Med. Chem. Res. 1997, 7, 546-556.
-
(1997)
Med. Chem. Res.
, vol.7
, pp. 546-556
-
-
Krikorian, D.1
Parushev, S.2
Tarpanov, V.3
Mechkarova, P.4
Mikhova, B.5
Botta, M.6
Corelli, F.7
Maga, G.8
Spadari, S.9
-
87
-
-
0031899273
-
Synthesis and biological evaluation of 5H-indolo [3,2b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126
-
Silvestri, R., Artico, M., Bruno, B., Massa, S., Novellino, E., Greco, G., Marongiu, M.E., Pani, A,, De Montis, A. and La Colla, P. Synthesis and biological evaluation of 5H-indolo [3,2b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126. Antiviral Chem. Chemother. 1998, 9, 139-148.
-
(1998)
Antiviral Chem. Chemother.
, vol.9
, pp. 139-148
-
-
Silvestri, R.1
Artico, M.2
Bruno, B.3
Massa, S.4
Novellino, E.5
Greco, G.6
Marongiu, M.E.7
Pani, A.8
De Montis, A.9
La Colla, P.10
-
88
-
-
0032901392
-
Pyrido [1,2a] indole derivatives identified as novel non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
-
Taylor, D.L., Ahmed, P.S., Chambers, P., Tyms, A.S., Bedard, J., Duchaine, J., Falardeau, G., Lavallée, J.F., Brown, W., Rando, R.F. and Bowlin, T. Pyrido [1,2a] indole derivatives identified as novel non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. Antiviral Chem. Chemother. 1999, 10, 79-86.
-
(1999)
Antiviral Chem. Chemother.
, vol.10
, pp. 79-86
-
-
Taylor, D.L.1
Ahmed, P.S.2
Chambers, P.3
Tyms, A.S.4
Bedard, J.5
Duchaine, J.6
Falardeau, G.7
Lavallée, J.F.8
Brown, W.9
Rando, R.F.10
Bowlin, T.11
-
89
-
-
0030317268
-
Nevirapine, zidovudine and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial
-
D'Aquila, R.T., Hughes, M.D., Johnson, V.A., Fischl, M.A., Sommadossi, J.P., Liou, S.H., Timpone, J., Myers, M., Basgoz, N., Niu, M. and Hirsch, M.S. Nevirapine, zidovudine and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 1996, 124, 1019-1030.
-
(1996)
Ann. Intern. Med.
, vol.124
, pp. 1019-1030
-
-
D'Aquila, R.T.1
Hughes, M.D.2
Johnson, V.A.3
Fischl, M.A.4
Sommadossi, J.P.5
Liou, S.H.6
Timpone, J.7
Myers, M.8
Basgoz, N.9
Niu, M.10
Hirsch, M.S.11
-
90
-
-
0026715575
-
Synthesis and anti-HIV activity of pyrrolo-[1,2-d]-(1,4)-benzodiazepin-6-ones
-
De Lucca, G.V. and Otto, M.J. Synthesis and anti-HIV activity of pyrrolo-[1,2-d]-(1,4)-benzodiazepin-6-ones. Bioorg. Med. Chem. Lett. 1992, 2, 1639-1644.
-
(1992)
Bioorg. Med. Chem. Lett.
, vol.2
, pp. 1639-1644
-
-
De Lucca, G.V.1
Otto, M.J.2
-
91
-
-
0031954544
-
1,2,5-Benzothiadiazepine and pyrrolo[2,1-d][1,2,5]benzo-thiadiazepine derivatives with specific anti-human immunodeficiency virus type 1 activity
-
Di Santo, R., Costi, R., Artico, M., Massa, S., Marongiu, M.E., Loi, A.G., De Montis, A. and La Colla, P. 1,2,5-Benzothiadiazepine and pyrrolo[2,1-d][1,2,5]benzo-thiadiazepine derivatives with specific anti-human immunodeficiency virus type 1 activity. Antiviral Chem. Chemother. 1998, 9, 127-137.
-
(1998)
Antiviral Chem. Chemother.
, vol.9
, pp. 127-137
-
-
Di Santo, R.1
Costi, R.2
Artico, M.3
Massa, S.4
Marongiu, M.E.5
Loi, A.G.6
De Montis, A.7
La Colla, P.8
-
92
-
-
0032747299
-
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity
-
Campiani, G., Morelli, E., Fabbrini, M., Nacci, V., Greco, G., Novellino, E., Ramunno, A., Maga, G., Spadari, S., Caliendo, G., Bergamini, A., Faggioli, E., Uccella, I., Bolacchi, F., Marini, S., Coletta, M., Nacca, A. and Caccia, S. Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. J. Med. Chem. 1999, 42, 4462-4470.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4462-4470
-
-
Campiani, G.1
Morelli, E.2
Fabbrini, M.3
Nacci, V.4
Greco, G.5
Novellino, E.6
Ramunno, A.7
Maga, G.8
Spadari, S.9
Caliendo, G.10
Bergamini, A.11
Faggioli, E.12
Uccella, I.13
Bolacchi, F.14
Marini, S.15
Coletta, M.16
Nacca, A.17
Caccia, S.18
-
93
-
-
0030992580
-
Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents
-
Hara, H., Fujihashi, T., Sakata, T., Kaji, A. and Kaji, H. Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents. AIDS Res. Hum. Retrovir. 1997, 13, 695-705.
-
(1997)
AIDS Res. Hum. Retrovir.
, vol.13
, pp. 695-705
-
-
Hara, H.1
Fujihashi, T.2
Sakata, T.3
Kaji, A.4
Kaji, H.5
-
94
-
-
0029041267
-
Benzophenone derivatives: A novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase
-
Wyatt, P.G., Bethell, R.C., Cammack, N., Charon, D., Dodic, N., Dumaitre, B., Evans, D.N., Green, D.V.S., Hopewell, P.L., Humber, D.C., Lamont, R.B., Orr, D.C., Plested, S.J., Ryan, D.M., Sollis, S.L., Storer, R. and Weingarten, G.G. Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase. J. Med. Chem. 1995, 38, 1657-1665.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 1657-1665
-
-
Wyatt, P.G.1
Bethell, R.C.2
Cammack, N.3
Charon, D.4
Dodic, N.5
Dumaitre, B.6
Evans, D.N.7
Green, D.V.S.8
Hopewell, P.L.9
Humber, D.C.10
Lamont, R.B.11
Orr, D.C.12
Plested, S.J.13
Ryan, D.M.14
Sollis, S.L.15
Storer, R.16
Weingarten, G.G.17
-
95
-
-
0034624679
-
Novel 1,5-diphenyl-pyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3- and 4-substituted derivatives
-
Genin, M.J., Biles, C., Keiser, B.J., Poppe, S.M., Swaney, S.M., Tarpley, W.G., Yagi, Y. and Romero, D.L. Novel 1,5-diphenyl-pyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives. J. Med. Chem. 2000, 43, 1034-1040.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1034-1040
-
-
Genin, M.J.1
Biles, C.2
Keiser, B.J.3
Poppe, S.M.4
Swaney, S.M.5
Tarpley, W.G.6
Yagi, Y.7
Romero, D.L.8
-
96
-
-
0035833106
-
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents
-
Barreca, M.L., Chimirri, A., De Luca, L., Monforte, A.-M., Monforte, P., Rao, A., Zappala, M., Balzarini, J., De Clercq, E., Pannecouque, C. and Witvrouw, M. Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents. Bioorg. Med. Chem. Lett. 2001, 11, 1793-1796.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 1793-1796
-
-
Barreca, M.L.1
Chimirri, A.2
De Luca, L.3
Monforte, A.-M.4
Monforte, P.5
Rao, A.6
Zappala, M.7
Balzarini, J.8
De Clercq, E.9
Pannecouque, C.10
Witvrouw, M.11
-
97
-
-
0035931438
-
3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent nonnucleoside reverse transcriptase inhibitors
-
Corbett, J.W., Pan, S., Markwalder, J.A., Cordova, B.C., Klabe, R.M., Garber, G., Rodgers, J.D. and Erickson-Viitanen, S.K. 3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent nonnucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. 2001, 11, 211-214.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 211-214
-
-
Corbett, J.W.1
Pan, S.2
Markwalder, J.A.3
Cordova, B.C.4
Klabe, R.M.5
Garber, G.6
Rodgers, J.D.7
Erickson-Viitanen, S.K.8
-
98
-
-
17944376896
-
Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU)
-
Ludovici, D.W., Kukla, M.J., Grous, P.G., Krishnan, S., Andries, K., de Béthune, M.-J., Azijn, H., Pauwels, R., De Clercq, E., Arnold, E. and Janssen, P.A.J. Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU). Bioorg. Med. Chem. Lett. 2001, 11, 2225-2228.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2225-2228
-
-
Ludovici, D.W.1
Kukla, M.J.2
Grous, P.G.3
Krishnan, S.4
Andries, K.5
de Béthune, M.-J.6
Azijn, H.7
Pauwels, R.8
De Clercq, E.9
Arnold, E.10
Janssen, P.A.J.11
-
99
-
-
17944374798
-
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues
-
Ludovici, D.W., De Corte, B.L., Kukla, M.J., Ye, H., Ho, C.Y., Lichtenstein, M.A., Kavash, R.W., Andries, K., de Béthune, M.-P., Azijn, H., Pauwels, R., Lewi, P.J., Heeres, J., Koymans, L.M.H., de Jonge, M.R., Van Aken, K.J.A., Daeyaert, F.F.D., Das, K., Arnold, E. and Janssen, P.A.J. Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorg. Med. Chem. Lett. 2001, 11, 2235-2239.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2235-2239
-
-
Ludovici, D.W.1
De Corte, B.L.2
Kukla, M.J.3
Ye, H.4
Ho, C.Y.5
Lichtenstein, M.A.6
Kavash, R.W.7
Andries, K.8
de Béthune, M.-P.9
Azijn, H.10
Pauwels, R.11
Lewi, P.J.12
Heeres, J.13
Koymans, L.M.H.14
de Jonge, M.R.15
Van Aken, K.J.A.16
Daeyaert, F.F.D.17
Das, K.18
Arnold, E.19
Janssen, P.A.J.20
more..
-
100
-
-
3042853234
-
R165335-TMC125, a novel non nucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains
-
Toronto, Canada Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
Andries, K., De Béthune, M.-P., Kukla, M.J., Azijn, H., Lewi, P.J., Janssen, P.A.J. and Pauwels, R. 2000. R165335-TMC125, a novel non nucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains. In Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada.
-
(2000)
-
-
Andries, K.1
De Béthune, M.-P.2
Kukla, M.J.3
Azijn, H.4
Lewi, P.J.5
Janssen, P.A.J.6
Pauwels, R.7
-
101
-
-
0038327026
-
TMC125, a next-generation NNRTI, demonstrates high potency after 7 days therapy in treatment-experienced HIV-1-infected individuals with phenotypic NNRTI resistance
-
Seattle, Washington, USA Abstracts of the Ninth Conference on Retroviruses and Opportunistic Infections
-
Gazzard, B., Pozniak, A., Arasteh, K., Staszewski, S., Rozenbaum, W., Yeni, P., van't Klooster, G., De Dier, K., Peeters, M., de Béthune, M.P., Graham, N. and Pauwels, R. 2002. TMC125, a next-generation NNRTI, demonstrates high potency after 7 days therapy in treatment-experienced HIV-1-infected individuals with phenotypic NNRTI resistance. In Abstracts of the Ninth Conference on Retroviruses and Opportunistic Infections. Seattle, Washington, USA.
-
(2002)
-
-
Gazzard, B.1
Pozniak, A.2
Arasteh, K.3
Staszewski, S.4
Rozenbaum, W.5
Yeni, P.6
van't Klooster, G.7
De Dier, K.8
Peeters, M.9
de Béthune, M.P.10
Graham, N.11
Pauwels, R.12
-
102
-
-
3042734703
-
-
Seattle, Washington, USA Abstracts of the Ninth Conference on Retroviruses and Opportunistic Infections
-
Sankatsing, S., Weverling, G., van't Klooster, G., Prins, J. and Lange, J. 2002. In Abstracts of the Ninth Conference on Retroviruses and Opportunistic Infections. Seattle, Washington, USA.
-
(2002)
-
-
Sankatsing, S.1
Weverling, G.2
van't Klooster, G.3
Prins, J.4
Lange, J.5
-
103
-
-
0035821597
-
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1
-
Chan, J.H., Hong, S.J., Hunter R.N. III, Orr, E.G., Cowan, J.R., Sherman, D.B., Sparks, S.M. and Reitter, B.E. 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J. Med. Chem. 2001, 44, 1866-1882.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1866-1882
-
-
Chan, J.H.1
Hong, S.J.2
Hunter III, R.N.3
Orr, E.G.4
Cowan, J.R.5
Sherman, D.B.6
Sparks, S.M.7
Reitter, B.E.8
-
104
-
-
0035139222
-
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2
-
Buckheit, R.W. Jr., Watson, K., Fliakas-Boltz, V., Russell, J., Loftus, T.L., Osterling, M.C., Turpin, J.A., Pallansch, L.A., White, E.L., Lee, J.-W., Lee, S.-H., Oh, J.-W., Kwon, H.-S., Chung, S.-G. and Cho, E.-H. SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2. Antimicrob. Agents Chemother. 2001, 45, 393-400.
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 393-400
-
-
Buckheit Jr., R.W.1
Watson, K.2
Fliakas-Boltz, V.3
Russell, J.4
Loftus, T.L.5
Osterling, M.C.6
Turpin, J.A.7
Pallansch, L.A.8
White, E.L.9
Lee, J.-W.10
Lee, S.-H.11
Oh, J.-W.12
Kwon, H.-S.13
Chung, S.-G.14
Cho, E.-H.15
-
105
-
-
0036394644
-
Pridine oxide derivatives: Structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture
-
Balzarini, J., Stevens, M., Andrei, G., Snoeck, R., Strunk, R., Pierce, J.B., Lacadie, J.A., De Clercq, E., Pannecouque, C. Pridine oxide derivatives: structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture. Helv. Chimica Acta 2002, 85, 2961-2974.
-
(2002)
Helv. Chimica Acta
, vol.85
, pp. 2961-2974
-
-
Balzarini, J.1
Stevens, M.2
Andrei, G.3
Snoeck, R.4
Strunk, R.5
Pierce, J.B.6
Lacadie, J.A.7
De Clercq, E.8
Pannecouque, C.9
-
106
-
-
0041421236
-
Inhibition of human immunodeficiency virus (HIV) by a new class of pyridine oxide derivatives
-
Stevens, M., Pannecouque, C., De Clercq, E. and Balzarini, J. Inhibition of human immunodeficiency virus (HIV) by a new class of pyridine oxide derivatives. Antimicrob. Agents Chemother 2003, 47, 2351-2357.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 2351-2357
-
-
Stevens, M.1
Pannecouque, C.2
De Clercq, E.3
Balzarini, J.4
-
107
-
-
0141925605
-
Novel human immunodeficiency virus (HIV) inhibitors having a dual mode of anti-HIV action
-
Stevens, M., Pannecouque, C., De Clercq, E. and Balzarini, J. Novel human immunodeficiency virus (HIV) inhibitors having a dual mode of anti-HIV action. Antimicrob. Agents Chemother 2003, 47, 3109-3116.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 3109-3116
-
-
Stevens, M.1
Pannecouque, C.2
De Clercq, E.3
Balzarini, J.4
-
108
-
-
0001178693
-
Biochemical pharmacology of nucleoside and non-nucleoside analogues active against HIV reverse transcriptase
-
Merigan, T.C., J.G. Bartlett, and D.P. Bolognesi (eds.). Second Ed. Williams & Wilkins, Baltimore, MD (1998)
-
Balzarini, J. and De Clercq, E. 1998. Biochemical pharmacology of nucleoside and non-nucleoside analogues active against HIV reverse transcriptase. In: Textbook of AIDS Medicine. Merigan, T.C., J.G. Bartlett, and D.P. Bolognesi (eds.). Second Ed. Williams & Wilkins, Baltimore, MD, pp. 815-847 (1998).
-
(1998)
Textbook of AIDS Medicine
, pp. 815-847
-
-
Balzarini, J.1
De Clercq, E.2
-
109
-
-
0029815914
-
Analysis of inhibition of retroviral reverse transcriptase
-
Balzarini, J., and E. De Clercq. Analysis of inhibition of retroviral reverse transcriptase. Methods in Enzymology 1996, 275, 472-502.
-
(1996)
Methods in Enzymology
, vol.275
, pp. 472-502
-
-
Balzarini, J.1
De Clercq, E.2
-
110
-
-
0028947588
-
High resolution structure of HIV-1 RT: Insights from four RT-inhibitor complexes
-
Ren, J.S., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D. and Stammmers, D. High resolution structure of HIV-1 RT: Insights from four RT-inhibitor complexes. Nat. Struct. Biol. 1995, 2, 293-302.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 293-302
-
-
Ren, J.S.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
Kirby, I.6
Keeling, J.7
Darby, G.8
Jones, Y.9
Stuart, D.10
Stammmers, D.11
-
111
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
Esnouf, R., J. Ren, C. Ross, Y. Jones, D. Stammers, and D. Stuart. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nature Struct. Biol. 1995, 2, 303-308.
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
112
-
-
0026693137
-
A Crystal structure at 3.5Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt, L.A, Wang, J., Friedman, J.M., Rice, P.A. and Steitz, T. A Crystal structure at 3.5Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992, 256, 1783-1790.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.5
-
113
-
-
34250082672
-
Review of HIV-1 reverse transcriptase three-dimensional structure: Implications for drug design
-
Nanni, R.G., Ding, J., Jacobo-Molina, A., Hughes, S.H., and Arnold, E. Review of HIV-1 reverse transcriptase three-dimensional structure: Implications for drug design. Perspect. Drug. Discov. Des. 1993, 1, 129-150.
-
(1993)
Perspect. Drug. Discov. Des.
, vol.1
, pp. 129-150
-
-
Nanni, R.G.1
Ding, J.2
Jacobo-Molina, A.3
Hughes, S.H.4
Arnold, E.5
-
114
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å shows bent DNA
-
Jacobo-Molina, A., Ding, J., Nanni, R.G., Clarck, A.D., Lu, X., Tantillo, C., Williams, R.L., Kame, G., Ferris, A.L., Clarck, P., Hitzi, A., Hughes, S.H. and Arnold, E. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å shows bent DNA. Proc. Natl. Acad. Sci. 1993, 90, 6320-6324.
-
(1993)
Proc. Natl. Acad. Sci.
, vol.90
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.2
Nanni, R.G.3
Clarck, A.D.4
Lu, X.5
Tantillo, C.6
Williams, R.L.7
Kame, G.8
Ferris, A.L.9
Clarck, P.10
Hitzi, A.11
Hughes, S.H.12
Arnold, E.13
-
115
-
-
0033169086
-
Strategies to suppress resistance to drugs targeted at human immunodeficiency virus reverse transcriptase by combination therapy
-
Balzarini, J. Strategies to suppress resistance to drugs targeted at human immunodeficiency virus reverse transcriptase by combination therapy. Commentary. Biochem. Pharmacol. 1999, 58, 1-27.
-
(1999)
Commentary. Biochem. Pharmacol.
, vol.58
, pp. 1-27
-
-
Balzarini, J.1
-
116
-
-
0031799218
-
Anti-human immunodeficiency virus drug combination strategies
-
Vandamme, A.-M., Van Vaerenbergh, K. and De Clercq, E. Anti-human immunodeficiency virus drug combination strategies. Antivir. Chem. Chemother. 1998, 9, 187-203.
-
(1998)
Antivir. Chem. Chemother.
, vol.9
, pp. 187-203
-
-
Vandamme, A.-M.1
Van Vaerenbergh, K.2
De Clercq, E.3
-
117
-
-
0029052967
-
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase
-
Patel, P.H., Jacobo-Molina, A., Ding, J., Tantillo, C., Clarck, A.D., Raag R. Jr., Nanni, R.G., Hughes, S.H. and Arnold, E. Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Biochemistry 1995, 34, 5351-5363.
-
(1995)
Biochemistry
, vol.34
, pp. 5351-5363
-
-
Patel, P.H.1
Jacobo-Molina, A.2
Ding, J.3
Tantillo, C.4
Clarck, A.D.5
Raag Jr., R.6
Nanni, R.G.7
Hughes, S.H.8
Arnold, E.9
-
118
-
-
0026724892
-
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2′,5′-bis-O-(tert-butyldimetlhylsilyl)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″-2″ -oxathiole-2″, 2″-di-oxide)thymine (TSAO-T)
-
Balzarini, J., Pérez-Pérez, M.-J., San-Félix, A., Camarasa, M.-J., Bathurst, I.C., P.J. Barr, and De Clercq, E. Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2′,5′-bis-O-(tert-butyldimetlhylsilyl)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″-2″ -oxathiole-2″, 2″-di-oxide)thymine (TSAO-T). J. Biol. Chem. 1992, 267, 11831-11838.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11831-11838
-
-
Balzarini, J.1
Pérez-Pérez, M.-J.2
San-Félix, A.3
Camarasa, M.-J.4
Bathurst, I.C.5
Barr, P.J.6
De Clercq, E.7
-
119
-
-
0026695234
-
Specific HIV-1 reverse transcriptase inhibitors
-
Debyser, Z., Pauwels, R., Andries, K. and De Clercq, E. Specific HIV-1 reverse transcriptase inhibitors. J. Enzyme Inhibition 1992, 6, 47-53
-
(1992)
J. Enzyme Inhibition
, vol.6
, pp. 47-53
-
-
Debyser, Z.1
Pauwels, R.2
Andries, K.3
De Clercq, E.4
-
120
-
-
0026341962
-
Kinetic interaction of human immunodeficiency virus type 1 reverse transcriptase with the antiviral tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepine-2-(1H)-thione compound, R82150
-
Frank, K.B., Noll, G.J., Connell, E.V. and Sim, I.S. Kinetic interaction of human immunodeficiency virus type 1 reverse transcriptase with the antiviral tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepine-2-(1H)-thione compound, R82150. J. Biol. Chem. 1991, 266, 14232-14236.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14232-14236
-
-
Frank, K.B.1
Noll, G.J.2
Connell, E.V.3
Sim, I.S.4
-
121
-
-
0026014455
-
A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates
-
White, E.L., Buckheit R.W. Jr., Ross, L.J., Germany, J.M., Andries, K., Pauwels, R., Janssen, W P.A.J., Shannon, M. and Chirigos, M.A. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991, 26, 257-266.
-
(1991)
Antiviral Res.
, vol.26
, pp. 257-266
-
-
White, E.L.1
Buckheit Jr., R.W.2
Ross, L.J.3
Germany, J.M.4
Andries, K.5
Pauwels, R.6
Janssen W, P.A.J.7
Shannon, M.8
Chirigos, M.A.9
-
122
-
-
0026100860
-
A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site
-
Wu, J.C., Warren, T.C., Adams, J., Proudfoot, J., Skiles, J., Raghavan, P., Perry, C., Potocki, I., Farina, P.R. and Grob, P.M. A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site. Biochemistry 1991, 30, 2022-2026.
-
(1991)
Biochemistry
, vol.30
, pp. 2022-2026
-
-
Wu, J.C.1
Warren, T.C.2
Adams, J.3
Proudfoot, J.4
Skiles, J.5
Raghavan, P.6
Perry, C.7
Potocki, I.8
Farina, P.R.9
Grob, P.M.10
-
123
-
-
0026318332
-
Reconstitution and properties of homologous and chimeric HIV-1. HIV-2 p66.p51 reverse transcriptase
-
Howard, K.J., Frank, K.B., Sim, I.S. and Le Grice, S.F. Reconstitution and properties of homologous and chimeric HIV-1. HIV-2 p66.p51 reverse transcriptase. J. Biol. Chem. 1991, 266, 23003-23009.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 23003-23009
-
-
Howard, K.J.1
Frank, K.B.2
Sim, I.S.3
Le Grice, S.F.4
-
124
-
-
0026052102
-
Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonucleoside analog inhibitors
-
Shih, C.K., Rose, J.M., Hansen, G.L., Wu, J.C., Bacolla, A. and Griffin, J.A. Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonucleoside analog inhibitors. Proc. Natl. Acad. Sci. USA 1991, 88, 9878-9882.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 9878-9882
-
-
Shih, C.K.1
Rose, J.M.2
Hansen, G.L.3
Wu, J.C.4
Bacolla, A.5
Griffin, J.A.6
-
125
-
-
0029989631
-
Use of chimeric human immunodeficiency virus types 1 and 2 reverse transcriptases for structure-function analysis and for mapping susceptibility to nonnucleoside inhibitors
-
Yang, G., Song, Q., Charles, M., Drosopoulos, W.C., Arnold, E. and Prasad, V.R. Use of chimeric human immunodeficiency virus types 1 and 2 reverse transcriptases for structure-function analysis and for mapping susceptibility to nonnucleoside inhibitors. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1996, 11, 326-333.
-
(1996)
J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.
, vol.11
, pp. 326-333
-
-
Yang, G.1
Song, Q.2
Charles, M.3
Drosopoulos, W.C.4
Arnold, E.5
Prasad, V.R.6
-
126
-
-
0027225174
-
Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors
-
Hizi, A., Tal, R., Shaharabany, M., Currens, M.J., Boyd, M.R., Hughes, S.H. and McMahon, J.B. Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors. Antimicrob. Agents Chemother. 1993, 37, 1037-1042.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1037-1042
-
-
Hizi, A.1
Tal, R.2
Shaharabany, M.3
Currens, M.J.4
Boyd, M.R.5
Hughes, S.H.6
McMahon, J.B.7
-
127
-
-
0031947138
-
Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor
-
Isaka, Y., Sato, A., Kawauchi, S., Suyama, A., Miki, S., Hayami, M. and Fujiwara, T. Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor. Microbiol. Immunol. 1998, 42, 195-202.
-
(1998)
Microbiol. Immunol.
, vol.42
, pp. 195-202
-
-
Isaka, Y.1
Sato, A.2
Kawauchi, S.3
Suyama, A.4
Miki, S.5
Hayami, M.6
Fujiwara, T.7
-
128
-
-
0032540238
-
An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukaemia virus RT exists as a monomer
-
Misra, H.S., Pandey, P.K. and Pandey, V.N. An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukaemia virus RT exists as a monomer. J. Biol. Chem. 1998, 273, 9785-9789.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9785-9789
-
-
Misra, H.S.1
Pandey, P.K.2
Pandey, V.N.3
-
129
-
-
0032525275
-
Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: Critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerises
-
Amacker, M. and Hubscher, U. Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerises. J. Mol. Biol. 1998, 278, 757-765.
-
(1998)
J. Mol. Biol.
, vol.278
, pp. 757-765
-
-
Amacker, M.1
Hubscher, U.2
-
130
-
-
0034083833
-
Mutations in retroviral genes associated with drug resistance: 2000-2001 update
-
Schinazi, R.F., Larder, B.A. and Mellors, J.N. Mutations in retroviral genes associated with drug resistance: 2000-2001 update. Int. Antivir. News 2000, 8, 65-91.
-
(2000)
Int. Antivir. News
, vol.8
, pp. 65-91
-
-
Schinazi, R.F.1
Larder, B.A.2
Mellors, J.N.3
-
131
-
-
0036156328
-
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptase: Role of the subunits in resistance/senstivity to non-nucleoside reverse transcriptase inhibitors
-
Auwerx, J., North, T.W., Preston, B.D., Klarmann, G.J., De Clercq, E. and Balzarini, J. Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptase: role of the subunits in resistance/senstivity to non-nucleoside reverse transcriptase inhibitors. Mol. Pharmacol. 2002, 61, 400-406.
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 400-406
-
-
Auwerx, J.1
North, T.W.2
Preston, B.D.3
Klarmann, G.J.4
De Clercq, E.5
Balzarini, J.6
-
132
-
-
0034053131
-
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases
-
Ren, J., Diprose, J., Warren, J., Esnouf, R.M., Bird, L.E., Ikemizu, S., Slater, M., Milton, J., Balzarini, J., Stuart, D.I. and Stammers, D.K. Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. J. Biol. Chem. 2000, 275, 5633-5639.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5633-5639
-
-
Ren, J.1
Diprose, J.2
Warren, J.3
Esnouf, R.M.4
Bird, L.E.5
Ikemizu, S.6
Slater, M.7
Milton, J.8
Balzarini, J.9
Stuart, D.I.10
Stammers, D.K.11
-
133
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence, R.A., Kati, W.M., Anderson, K.S. and Johnson, K.A. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 1995, 267, 988-993.
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
134
-
-
0029153101
-
Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds
-
Fletcher, R.S., Arion, D., Borkow, G., Wainberg, M.A., Dmitrienko, G.I. and Parniak, M.A. Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Biochemistry 1995, 34, 10106-10112.
-
(1995)
Biochemistry
, vol.34
, pp. 10106-10112
-
-
Fletcher, R.S.1
Arion, D.2
Borkow, G.3
Wainberg, M.A.4
Dmitrienko, G.I.5
Parniak, M.A.6
-
135
-
-
0028922944
-
Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme
-
Fletcher, R.S., Syed, K., Mithani, S., Dmitrienko, G.I. and Parniak, M.A. Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme. Biochemistry 1995, 34, 4346-4353.
-
(1995)
Biochemistry
, vol.34
, pp. 4346-4353
-
-
Fletcher, R.S.1
Syed, K.2
Mithani, S.3
Dmitrienko, G.I.4
Parniak, M.A.5
-
136
-
-
0028271687
-
Structure of the bindng site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
-
Smerdon, S.J., Jäger, J., Wang, J., Kohlstaedt, L.A., Chirino, A.J., Friedman, J.M., Rice, P.A. and Steitz, T.A. Structure of the bindng site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc. Natl. Sci. USA. 1994, 91, 3911-3915.
-
(1994)
Proc. Natl. Sci. USA
, vol.91
, pp. 3911-3915
-
-
Smerdon, S.J.1
Jäger, J.2
Wang, J.3
Kohlstaedt, L.A.4
Chirino, A.J.5
Friedman, J.M.6
Rice, P.A.7
Steitz, T.A.8
-
137
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase. Implications of drug resistance
-
Huang, H.F., Chopra, R., Verdine, G.L. and Harrison, S.C. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase. Implications of drug resistance. Science 1998, 282, 1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.F.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
138
-
-
0028151170
-
Crystals of HIV-1 reverse transcriptase diffracting to 2.2 Å resolution
-
Stammers, D.K., Somers, D.O., Ross, C.K., Kirby, I., Ray, P.H., Wilson, J.E., Norman, M., Ren, J.S., Esnouf, R.M., Garman, E.F., Jones, E.Y. and Stuart, D.I. Crystals of HIV-1 reverse transcriptase diffracting to 2.2 Å resolution. J. Mol. Biol. 1994, 242, 586-588.
-
(1994)
J. Mol. Biol.
, vol.242
, pp. 586-588
-
-
Stammers, D.K.1
Somers, D.O.2
Ross, C.K.3
Kirby, I.4
Ray, P.H.5
Wilson, J.E.6
Norman, M.7
Ren, J.S.8
Esnouf, R.M.9
Garman, E.F.10
Jones, E.Y.11
Stuart, D.I.12
-
139
-
-
0028842293
-
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
-
Hellmig, B., Woolf, D.J., Debouck, C. and Harrison, S.C. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 1995, 92, 1222-1226.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1222-1226
-
-
Hellmig, B.1
Woolf, D.J.2
Debouck, C.3
Harrison, S.C.4
-
140
-
-
3042774335
-
Crystal structures of wild-type and mutant HIV-1 reverse transcriptase and non-nucleoside inhibitors: Implications for drug resistance mechanisms
-
Italy Abstracts of the Second International Workshop on HIV Drug Resistance and Treatment Strategies
-
Hsiou,Y., Das, K., Ding, J., Clarck A.D. Jr., Boyer, P.L., Janssen, P.A.J., Kleim, J.-P., Rosner, M., Hughes, S.H. and Arnold, E. 1998. Crystal structures of wild-type and mutant HIV-1 reverse transcriptase and non-nucleoside inhibitors: Implications for drug resistance mechanisms. In Abstracts of the Second International Workshop on HIV Drug Resistance and Treatment Strategies. Italy.
-
(1998)
-
-
Hsiou, Y.1
Das, K.2
Ding, J.3
Clarck Jr., A.D.4
Boyer, P.L.5
Janssen, P.A.J.6
Kleim, J.-P.7
Rosner, M.8
Hughes, S.H.9
Arnold, E.10
-
141
-
-
0035368238
-
The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
-
Hsiou, Y., Ding, J., Das, K., Clark A.D. Jr., Boyer, P.L., Lewi, P., Janssen, P.A., Kleim, J.P., Rosner, M., Hughes, S.H. and Arnold, E. The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J. Mol. Biol. 2001, 309, 437-445.
-
(2001)
J. Mol. Biol.
, vol.309
, pp. 437-445
-
-
Hsiou, Y.1
Ding, J.2
Das, K.3
Clark Jr., A.D.4
Boyer, P.L.5
Lewi, P.6
Janssen, P.A.7
Kleim, J.P.8
Rosner, M.9
Hughes, S.H.10
Arnold, E.11
-
142
-
-
0035965124
-
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation nonnucleoside inhibitors
-
Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I. and Stammers, D.K. Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation nonnucleoside inhibitors. J. Mol. Biol. 2001, 312, 795-805.
-
(2001)
J. Mol. Biol.
, vol.312
, pp. 795-805
-
-
Ren, J.1
Nichols, C.2
Bird, L.3
Chamberlain, P.4
Weaver, K.5
Short, S.6
Stuart, D.I.7
Stammers, D.K.8
-
143
-
-
0036776359
-
Crystal structures of zidovudine- or lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184 and 215
-
Chamberlain, P.P., Ren, J., Nichols, C.E., Douglas, L., Lennerstrand, J., Larder, B.A., Stuart, D.I. and Stammers, D.K. Crystal structures of zidovudine- or lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184 and 215. J. Virol. 2002, 76, 10015-10019.
-
(2002)
J. Virol.
, vol.76
, pp. 10015-10019
-
-
Chamberlain, P.P.1
Ren, J.2
Nichols, C.E.3
Douglas, L.4
Lennerstrand, J.5
Larder, B.A.6
Stuart, D.I.7
Stammers, D.K.8
-
144
-
-
0032167707
-
Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration
-
Esnouf, R.M., Ren, J., Garman, E.F., 'ON Somers, D., Ross, C.K., Jones, E.Y., Stammers, D.K. and Stuart, D.I. Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration. Acta Cryst. 1998, D54, 938-953.
-
(1998)
Acta Cryst.
, vol.D54
, pp. 938-953
-
-
Esnouf, R.M.1
Ren, J.2
Garman, E.F.3
'ON Somers, D.4
Ross, C.K.5
Jones, E.Y.6
Stammers, D.K.7
Stuart, D.I.8
-
145
-
-
0030935265
-
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
-
Esnouf, R.M., Ren, J., Hopkins, A.L., Ross, A.K., Jones, E.Y., Stammers, D.K. and Stuart, D.I. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Proc. Natl. Acad. Sci. 1997, 94, 3984-3989.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 3984-3989
-
-
Esnouf, R.M.1
Ren, J.2
Hopkins, A.L.3
Ross, A.K.4
Jones, E.Y.5
Stammers, D.K.6
Stuart, D.I.7
-
146
-
-
0029976422
-
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors
-
Miyasaka, C., Walker, R.T., Tanaka, H., Stammers, D.K. and Stuart, D.I. Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J. Med. Chem. 1996, 39, 1589-1600.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1589-1600
-
-
Miyasaka, C.1
Walker, R.T.2
Tanaka, H.3
Stammers, D.K.4
Stuart, D.I.5
-
147
-
-
0035821586
-
Identification of a putative binding site for [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″,2″ -oxathiole-2″, 2″-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase
-
Rodríguez- Barrios, F., Pérez, C., Lobatón, E., Velázquez, S., Chamorro, C., San-Félix, A., Pé rez-Pérez, M.-J., Camarasa, M.-J., Pelemans, H., Balzarini, J. and Gago, F. Identification of a putative binding site for [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″,2″ -oxathiole-2″, 2″-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. J. Med. Chem. 2001, 44, 1853-1865.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1853-1865
-
-
Rodríguez- Barrios, F.1
Pérez, C.2
Lobatón, E.3
Velázquez, S.4
Chamorro, C.5
San-Félix, A.6
Pé rez-Pérez, M.-J.7
Camarasa, M.-J.8
Pelemans, H.9
Balzarini, J.10
Gago, F.11
-
148
-
-
0029804757
-
Differences in the inhibition of human immunodeficiency virus type 1 reverse trans-criptase DNA polymerase activity by analogs of nevirapine and [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′ -spiro-5″-(4″-amino-1″, 2″-oxathiole-2″ ,2″-dioxide] (TSAO)
-
Arion, D., Fletcher, R.S., Borkow, G., Camarasa, M.J., Balzarini, J., Dmitrienko, G.I. and Parniak, M.A. Differences in the inhibition of human immunodeficiency virus type 1 reverse trans-criptase DNA polymerase activity by analogs of nevirapine and [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′ -spiro-5″-(4″-amino-1″, 2″-oxathiole-2″ ,2″-dioxide] (TSAO). Mol. Pharmacol. 1996, 50, 1057-1064.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1057-1064
-
-
Arion, D.1
Fletcher, R.S.2
Borkow, G.3
Camarasa, M.J.4
Balzarini, J.5
Dmitrienko, G.I.6
Parniak, M.A.7
-
149
-
-
0034673154
-
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[spiro-[4″-amino-2″,2″-dioxo-1″,2″ -oxathiole-5″, 3′-[2′,5′ -bis-O-(tert-butyldimethylsilyl) -β-D-ribofuranosyl]]]-3-ethylthymine
-
Sluis-Cremer, N., Dmitrienko, G.I., Balzarini, J., Camarasa, M. and Parniak, P.A. Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[spiro-[4″-amino-2″,2″-dioxo-1″,2″ -oxathiole-5″,3′-[2′, 5′ -bis-O-(tert-butyldimethylsilyl) -β -D-ribofuranosyl]]]-3-ethylthymine. Biochemistry 2000, 39, 1427-1433.
-
(2000)
Biochemistry
, vol.39
, pp. 1427-1433
-
-
Sluis-Cremer, N.1
Dmitrienko, G.I.2
Balzarini, J.3
Camarasa, M.4
Parniak, P.A.5
-
150
-
-
0032574687
-
The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer
-
Harris, D., Lee, R., Misra, H.S., Pandey, P.K. and Pandey, V.N. The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer. Biochemistry 1998, 37, 5903-5908.
-
(1998)
Biochemistry
, vol.37
, pp. 5903-5908
-
-
Harris, D.1
Lee, R.2
Misra, H.S.3
Pandey, P.K.4
Pandey, V.N.5
-
151
-
-
0025297454
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase
-
Restle, T., Müller, B. and Goody, R.S. Dimerization of human immunodeficiency virus type 1 reverse transcriptase. J. Biol. Chem. 1990, 265, 8986-8988.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8986-8988
-
-
Restle, T.1
Müller, B.2
Goody, R.S.3
-
152
-
-
0028308202
-
Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain
-
Divita, G., Restle, T., Goody, R.S., Chermann, J.-C. and Baillon, J.G. Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain. J. Biol. Chem. 1994, 269, 13080-13083.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13080-13083
-
-
Divita, G.1
Restle, T.2
Goody, R.S.3
Chermann, J.-C.4
Baillon, J.G.5
-
153
-
-
0028851734
-
Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors
-
Divita, G., Baillon, J.G., Rittinger, K., Chermann, J.-C. and Goody, R.S. Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors. J. Biol. Chem. 1995, 270, 28642-28646.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28642-28646
-
-
Divita, G.1
Baillon, J.G.2
Rittinger, K.3
Chermann, J.-C.4
Goody, R.S.5
-
154
-
-
0033609895
-
A new potent HIV-1 reverse transcriptase inhibitor
-
Morris, M.C., Robert-Hebmann, V., Chaloin, L., Mery, J., Heitz, F., Devaux, C., Goody, R.S. and Divita, G. A new potent HIV-1 reverse transcriptase inhibitor. J. Biol. Chem. 1999, 274, 24941-24946.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24941-24946
-
-
Morris, M.C.1
Robert-Hebmann, V.2
Chaloin, L.3
Mery, J.4
Heitz, F.5
Devaux, C.6
Goody, R.S.7
Divita, G.8
-
155
-
-
0037195081
-
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors
-
Ren, J., Bird, L.E., Chamberlain, P.P., Stewart-Jones, G.B., Stuart, D.I. and Stammers, D.K. Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to nonnucleoside inhibitors. Proc. Natl. Acad. Sci. USA 2002, 99, 14410-14415.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14410-14415
-
-
Ren, J.1
Bird, L.E.2
Chamberlain, P.P.3
Stewart-Jones, G.B.4
Stuart, D.I.5
Stammers, D.K.6
-
156
-
-
0028285185
-
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C → C181I)RT HIV-1 mutants
-
Balzarini, J., Karlsson, A., Sardana, V.V., Emini, E.A., Camarasa, M.-J. and De Clercq, E. Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C → C181I)RT HIV-1 mutants. Proc. Natl. Acad. Sci. USA 1994, 91, 6599-6603.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6599-6603
-
-
Balzarini, J.1
Karlsson, A.2
Sardana, V.V.3
Emini, E.A.4
Camarasa, M.-J.5
De Clercq, E.6
-
157
-
-
0029075207
-
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
-
Ding, J., Das, K., Moereels, H., Koymans, L., Andries, K., Janssen, P.A.J., Hughes, S.H. and Arnold, E. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat. Struct. Biol. 1995, 2, 407-415.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 407-415
-
-
Ding, J.1
Das, K.2
Moereels, H.3
Koymans, L.4
Andries, K.5
Janssen, P.A.J.6
Hughes, S.H.7
Arnold, E.8
-
158
-
-
0028024028
-
Subunit specificity of mutations that confer resistance to non-nucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase
-
Boyer, P.L., Ding, J., Arnold, E. and Hughes, S.H. Subunit specificity of mutations that confer resistance to non-nucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 1994, 38, 1909-1914.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1909-1914
-
-
Boyer, P.L.1
Ding, J.2
Arnold, E.3
Hughes, S.H.4
-
159
-
-
0028099251
-
138 → Lys on the p51 subunit
-
138 → Lys on the p51 subunit. J. Biol. Chem. 1994, 269, 25255-25258.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25255-25258
-
-
Jonckheere, H.1
Taymans, J.-M.2
Balzarini, J.3
Velazquez, S.4
Camarasa, M.-J.5
Desmyter, J.6
De Clercq, E.7
Anné, J.8
-
160
-
-
0027328082
-
HIV-1 specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase
-
Balzarini J., Karlsson, A., Pérez-Pérez, M.-J., Vrang, L., Walbers, J., Zhang, H., Oberg, B., Vandamme, A.-M. and De Clercq, E. HIV-1 specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Virology 1993, 192, 246-253.
-
(1993)
Virology
, vol.192
, pp. 246-253
-
-
Balzarini, J.1
Karlsson, A.2
Pérez-Pérez, M.-J.3
Vrang, L.4
Walbers, J.5
Zhang, H.6
Oberg, B.7
Vandamme, A.-M.8
De Clercq, E.9
-
161
-
-
0027202617
-
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′ -spiro-5″-(4″-amino-1″, 2″-oxathiole-2″ ,2″-dioxide)]-β-D-pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors
-
Balzarini, J., Karlsson, A., Vandamme, A.-M., Pérez-Pérez, M.-J., Zhang, H., Vrang, L., Öberg, B., Bäckbro, K., Unge, T., San-Félix, A., Velazquez, S., Camarasa, M.-J. and De Clercq, E. Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′ -spiro-5″-(4″-amino-1″, 2″-oxathiole-2″ ,2″-dioxide)]-β-D-pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors Proc. Natl. Acad. Sci. USA 1993, 90, 6952-6956.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6952-6956
-
-
Balzarini, J.1
Karlsson, A.2
Vandamme, A.-M.3
Pérez-Pérez, M.-J.4
Zhang, H.5
Vrang, L.6
Öberg, B.7
Bäckbro, K.8
Unge, T.9
San-Félix, A.10
Velazquez, S.11
Camarasa, M.-J.12
De Clercq, E.13
-
162
-
-
0028068907
-
Sensitivity of (138 Glu_Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors
-
Balzarini, J., Kleim, J.-P., Riess, G., Camarasa, M.-J., De Clercq, E. and Karlsson, A. Sensitivity of (138 Glu_Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors. Biochem. Biophys. Res. Commun. 1994, 201, 1305-1312.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.201
, pp. 1305-1312
-
-
Balzarini, J.1
Kleim, J.-P.2
Riess, G.3
Camarasa, M.-J.4
De Clercq, E.5
Karlsson, A.6
-
163
-
-
17544387814
-
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives
-
Esnouf, R.M., Stuart, D.I., De Clercq, E., Schwartz, E. and Balzarini, J. Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. Biochem. Biophys. Res. Commun. 1997, 234, 458-464.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.234
, pp. 458-464
-
-
Esnouf, R.M.1
Stuart, D.I.2
De Clercq, E.3
Schwartz, E.4
Balzarini, J.5
-
164
-
-
0032514718
-
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives
-
Ren, J., Esnouf, R.M., Hopkins, A.L., Warren, J., Balzarini, J., Stuart, D.I. and Stammers, D. Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Biochemistry 1998, 37, 14394-14403.
-
(1998)
Biochemistry
, vol.37
, pp. 14394-14403
-
-
Ren, J.1
Esnouf, R.M.2
Hopkins, A.L.3
Warren, J.4
Balzarini, J.5
Stuart, D.I.6
Stammers, D.7
-
165
-
-
3042775471
-
Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance
-
Int. Antiviral News, MediTech Media Ltd
-
Mellors, J.W., Larder, B.A. and Schinazi, R.F. 1998. Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. Int. Antiviral News, MediTech Media Ltd.
-
(1998)
-
-
Mellors, J.W.1
Larder, B.A.2
Schinazi, R.F.3
-
166
-
-
0027209906
-
Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors
-
Byrnes, V.W., Sardana, V.V., Schleif, W.A., Condra, J.H., Waterbury, J.A., Wolfgang, J.A., Long, W.J., Schneider, C.L., Schlabach, A.J., Wolanski, B.S., Graham, D.J., Gotlib, L., Rhodes, A., Titus, D.L., Roth, E., Blahy, O.M., Quintero, J.C., Staszewski, S. and Emini, E.A. Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors. Antimicrob. Agents Chemother. 1993, 37, 1576-1579.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1576-1579
-
-
Byrnes, V.W.1
Sardana, V.V.2
Schleif, W.A.3
Condra, J.H.4
Waterbury, J.A.5
Wolfgang, J.A.6
Long, W.J.7
Schneider, C.L.8
Schlabach, A.J.9
Wolanski, B.S.10
Graham, D.J.11
Gotlib, L.12
Rhodes, A.13
Titus, D.L.14
Roth, E.15
Blahy, O.M.16
Quintero, J.C.17
Staszewski, S.18
Emini, E.A.19
-
167
-
-
0027278781
-
Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents
-
Richman, D.D. Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents. Antimicrob. Agents Chemother. 1993, 37, 1207-1213.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1207-1213
-
-
Richman, D.D.1
-
168
-
-
0027214433
-
Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells by combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy
-
Balzarini, J. Karlsson, A., Pérez-Pérez, M.-J., Camarasa, M.-J., Tarpley, W.G., and De Clercq, E. Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells by combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy. J. Virol. 1993, 67, 5353-5359.
-
(1993)
J. Virol.
, vol.67
, pp. 5353-5359
-
-
Balzarini, J.1
Karlsson, A.2
Pérez-Pérez, M.-J.3
Camarasa, M.-J.4
Tarpley, W.G.5
De Clercq, E.6
-
169
-
-
0027957791
-
Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
-
Richman, D.D., Havlir, D., Corbeil, J., Looney, D., Ignacio, C., Spector, S.A., Sullivan, J., Cheeseman, S., Barringer, K., Pauletti, D., Myers, C.-K., and Griffin, J. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J. Virol. 1994, 68, 1660-1666.
-
(1994)
J. Virol.
, vol.68
, pp. 1660-1666
-
-
Richman, D.D.1
Havlir, D.2
Corbeil, J.3
Looney, D.4
Ignacio, C.5
Spector, S.A.6
Sullivan, J.7
Cheeseman, S.8
Barringer, K.9
Pauletti, D.10
Myers, C.-K.11
Griffin, J.12
-
170
-
-
0026806436
-
Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors
-
Vasudevachari, M.B., Battista, C., Lane, H.C., Psallidopoulos, M.C., Zhao, B., Cook, J., Palmer, J.R., Romero, D.L., Tarpley, W.G. and Salzman, N.P. Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors. Virology 1992, 190, 269-277.
-
(1992)
Virology
, vol.190
, pp. 269-277
-
-
Vasudevachari, M.B.1
Battista, C.2
Lane, H.C.3
Psallidopoulos, M.C.4
Zhao, B.5
Cook, J.6
Palmer, J.R.7
Romero, D.L.8
Tarpley, W.G.9
Salzman, N.P.10
-
171
-
-
3042856675
-
Development of high-level resistance to DMP 266 requires multiple mutations in the reverse transcriptase gene
-
6-9 July 1995, Sardinia, Italy, no. 13 Abstracts of the Fourth International Workshop on HIV Drug Resistance
-
Winslow, D.L., Garber, S., Reid, C., Scarnati, H., Korant, B., Emini, E. and Anton, E.D. 1995. Development of high-level resistance to DMP 266 requires multiple mutations in the reverse transcriptase gene. In Abstracts of the Fourth International Workshop on HIV Drug Resistance, 6-9 July 1995, Sardinia, Italy, no. 13.
-
(1995)
-
-
Winslow, D.L.1
Garber, S.2
Reid, C.3
Scarnati, H.4
Korant, B.5
Emini, E.6
Anton, E.D.7
-
172
-
-
3042857907
-
Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266
-
7-12 July 1996, Whistler, Canada, no. 10
-
Winslow, D.L., Reid, C., Garber, S., Scarnati, H., Rayner, M. and Anton, E. 1996. Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266. In Abstracts of the Fifth International Workshop on HIV Drug Resistance, 7-12 July 1996, Whistler, Canada, no. 10.
-
(1996)
Abstracts of the Fifth International Workshop on HIV Drug Resistance
-
-
Winslow, D.L.1
Reid, C.2
Garber, S.3
Scarnati, H.4
Rayner, M.5
Anton, E.6
-
173
-
-
3042812647
-
Virological Resistance to Efavirenz
-
Geneva, Switzerland, no. 41213 Abstracts of the 12th World AIDS Conference
-
Bacheler, L., Weislow, O., Snyder, S. and Hanna, P.G. 1998. Virological Resistance to Efavirenz. Abstracts of the 12th World AIDS Conference, Geneva, Switzerland, no. 41213.
-
(1998)
-
-
Bacheler, L.1
Weislow, O.2
Snyder, S.3
Hanna, P.G.4
-
174
-
-
0029011342
-
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains
-
Balzarini, J., Brouwer, W.G., Felauer, E.E., De Clercq, E. and Karlsson, A. Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains. Antiviral Res. 1995, 27, 219-236.
-
(1995)
Antiviral Res.
, vol.27
, pp. 219-236
-
-
Balzarini, J.1
Brouwer, W.G.2
Felauer, E.E.3
De Clercq, E.4
Karlsson, A.5
-
175
-
-
0029125583
-
Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s
-
Fan, N., K.B. Rank, D.B. Evans, R.C. Thomas, W.G. Tarpley, and S.K. Sharma.. Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s. FEBS Lett. 1995, 370, 59-62.
-
(1995)
FEBS Lett.
, vol.370
, pp. 59-62
-
-
Fan, N.1
Rank, K.B.2
Evans, D.B.3
Thomas, R.C.4
Tarpley, W.G.5
Sharma, S.K.6
-
176
-
-
3042733475
-
RT gene mutations associated with resistance to efavirenz
-
Sustiva Resistance Study Team Abstracts of the Second International Workshop on HIV Drug Resistance
-
Bacheler, L.T., Anton, E., Jeffrey, S., George, H., Hollis, G., Abremski, A. and Sustiva Resistance Study Team. 1998. RT gene mutations associated with resistance to efavirenz. In Abstracts of the Second International Workshop on HIV Drug Resistance.
-
(1998)
-
-
Bacheler, L.T.1
Anton, E.2
Jeffrey, S.3
George, H.4
Hollis, G.5
Abremski, A.6
-
177
-
-
0029897567
-
(Alkylamino)piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes
-
Olmsted, R.A., Slade, D.E., Kopta, L.A., Poppe, S.M., Poel, T.J., Newport, S.W., Rank, K.B., Biles, C., Morge, R.A., Dueweke, T.J., Yagi, Y., Romero, D.L., Thomas, R.C., Sharma, S.K. and Tarpley, W.G. (Alkylamino)piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes. J. Virol. 1996, 70, 3698-3705.
-
(1996)
J. Virol.
, vol.70
, pp. 3698-3705
-
-
Olmsted, R.A.1
Slade, D.E.2
Kopta, L.A.3
Poppe, S.M.4
Poel, T.J.5
Newport, S.W.6
Rank, K.B.7
Biles, C.8
Morge, R.A.9
Dueweke, T.J.10
Yagi, Y.11
Romero, D.L.12
Thomas, R.C.13
Sharma, S.K.14
Tarpley, W.G.15
-
178
-
-
0027231438
-
A mutation in revese transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors
-
Dueweke, T.J. Pushkarskaya, T., Poppe, S.M., Swaney, S.M., Zhao, Q., Chen, S.Y., Stevenson, M. and Tarpley, W.G. A mutation in revese transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors. Proc. Natl. Acad. Sci. 1993, 90, 4713-4717.
-
(1993)
Proc. Natl. Acad. Sci.
, vol.90
, pp. 4713-4717
-
-
Dueweke, T.J.1
Pushkarskaya, T.2
Poppe, S.M.3
Swaney, S.M.4
Zhao, Q.5
Chen, S.Y.6
Stevenson, M.7
Tarpley, W.G.8
-
179
-
-
0030926748
-
In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure on the nonnucleoside reverse transcriptase inhibitor HBY 097
-
Kleim, J.P., Winkler, I., Rosner, M., Kirsch, R., Rubsamen-Waigmann, H., Paessens, A. and Reiss, G. In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure on the nonnucleoside reverse transcriptase inhibitor HBY 097. Virology 1997, 231, 112-118.
-
(1997)
Virology
, vol.231
, pp. 112-118
-
-
Kleim, J.P.1
Winkler, I.2
Rosner, M.3
Kirsch, R.4
Rubsamen-Waigmann, H.5
Paessens, A.6
Reiss, G.7
-
180
-
-
0032545420
-
Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase
-
Pelemans, H., Esnouf, R.M., Jonckheere, H., De Clercq, E. and Balzarini, J. Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase. J. Biol. Chem. 1998, 273, 34234-34239.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 34234-34239
-
-
Pelemans, H.1
Esnouf, R.M.2
Jonckheere, H.3
De Clercq, E.4
Balzarini, J.5
-
181
-
-
0031940767
-
A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer
-
Boyer, P.L., Gao, H.-Q. and Hughes, S.H. A mutation at position 190 of human immunodeficiency virus type 1 reverse transcriptase interacts with mutations at positions 74 and 75 via the template primer. Antimicrob. Agents Chemother. 1998, 42, 447-452.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 447-452
-
-
Boyer, P.L.1
Gao, H.-Q.2
Hughes, S.H.3
-
182
-
-
0030070683
-
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-Val or Ile and Val-75-Leu or Ile) HIV-1 mutants
-
Kleim, J.P., Rosner, M., Winkler, I., Paessens, A., Kirsch, R., Hsiou, Y., Arnold, E. and Riess, G. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-Val or Ile and Val-75-Leu or Ile) HIV-1 mutants. Proc. Natl. Acad. Sci. USA 1996, 93, 34-38.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 34-38
-
-
Kleim, J.P.1
Rosner, M.2
Winkler, I.3
Paessens, A.4
Kirsch, R.5
Hsiou, Y.6
Arnold, E.7
Riess, G.8
-
183
-
-
0026454435
-
3-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors
-
Larder, B.A. 3-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 1992, 36, 2664-2669.
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2664-2669
-
-
Larder, B.A.1
-
184
-
-
0028333887
-
Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors
-
Byrnes, V.W., Emini, E.A., Schleif, W.A., Condra, J.H., Schneider, C.L., Long, W.J., Wolfgang, J.A., Graham, D.J., Gotlib, L., Schlabach, A.J., Wolanski, B.S., Blahy, O.M., Quintero, J.C., Rhodes, A., Roth, E., Titus, D.L. and Sardana, V.V. Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors. Antimicrob. Agents Chemother. 1994, 38, 1404-1407.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1404-1407
-
-
Byrnes, V.W.1
Emini, E.A.2
Schleif, W.A.3
Condra, J.H.4
Schneider, C.L.5
Long, W.J.6
Wolfgang, J.A.7
Graham, D.J.8
Gotlib, L.9
Schlabach, A.J.10
Wolanski, B.S.11
Blahy, O.M.12
Quintero, J.C.13
Rhodes, A.14
Roth, E.15
Titus, D.L.16
Sardana, V.V.17
-
185
-
-
0029044698
-
Novel mutations in the reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates
-
Mellors, J., Bazmi, H., Schinazi, R.F., Roy, B.M., Hsiou, Y., Arnold, E., Weir, J. and Mayers, D. Novel mutations in the reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates. Antimicrob. Agents Chemother. 1995, 39, 1087-1092.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1087-1092
-
-
Mellors, J.1
Bazmi, H.2
Schinazi, R.F.3
Roy, B.M.4
Hsiou, Y.5
Arnold, E.6
Weir, J.7
Mayers, D.8
-
186
-
-
0029792446
-
Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet
-
Tachedjian, G., Mellors, J., Bazmi, H., Birch, C. and Mills, J. Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet. J. Virol. 1996, 70, 7171-7181.
-
(1996)
J. Virol.
, vol.70
, pp. 7171-7181
-
-
Tachedjian, G.1
Mellors, J.2
Bazmi, H.3
Birch, C.4
Mills, J.5
-
187
-
-
0035695372
-
Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture
-
Balzarini, J. and De Clercq, E. Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture. AIDS Res. Hum. Retrovir. 2001, 17, 1625-1634.
-
(2001)
AIDS Res. Hum. Retrovir.
, vol.17
, pp. 1625-1634
-
-
Balzarini, J.1
De Clercq, E.2
-
188
-
-
3042818603
-
A conserved drug target in the HIV genome
-
in press
-
Anderson, J.N. 2003. A conserved drug target in the HIV genome. Gene. Ther. Mol. Biol., in press.
-
(2003)
Gene. Ther. Mol. Biol.
-
-
Anderson, J.N.1
-
189
-
-
0028301837
-
Nucleotide composition as a driving force in the evolution of retroviruses
-
Bronson, E.C. and Anderson, J.N. Nucleotide composition as a driving force in the evolution of retroviruses. J. Mol. Evol. 1994, 38, 506-532.
-
(1994)
J. Mol. Evol.
, vol.38
, pp. 506-532
-
-
Bronson, E.C.1
Anderson, J.N.2
-
190
-
-
0028228748
-
High rates of frameshift mutations within homo-oligomeric runs during a single cycle of retroviral replication
-
Burns, D.P.W. and Temin, H.M. High rates of frameshift mutations within homo-oligomeric runs during a single cycle of retroviral replication. J. Virol. 1994, 68, 4196-4203.
-
(1994)
J. Virol.
, vol.68
, pp. 4196-4203
-
-
Burns, D.P.W.1
Temin, H.M.2
-
191
-
-
0030070476
-
Compositional similarities between the human immunodeficiency virus and surface antigens of pathogens
-
Fitzgerald, D.J., Bronson, E.C. and Anderson, J.N. Compositional similarities between the human immunodeficiency virus and surface antigens of pathogens. AIDS Res. Hum. Retrovir. 1995, 12, 99-109.
-
(1995)
AIDS Res. Hum. Retrovir.
, vol.12
, pp. 99-109
-
-
Fitzgerald, D.J.1
Bronson, E.C.2
Anderson, J.N.3
-
192
-
-
0028125063
-
Tenth anniversary perspectives on AIDS, HIV: Between past and future
-
Meyers, G. Tenth anniversary perspectives on AIDS, HIV: between past and future. AIDS Res. Hum. Retrovir. 1994, 10, 1317-1324.
-
(1994)
AIDS Res. Hum. Retrovir.
, vol.10
, pp. 1317-1324
-
-
Meyers, G.1
-
193
-
-
0027976787
-
Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools
-
Meyerhans, A., Vartanian, J.-P., Hultgren, C., Plikat, U., Karlsson, A., Wang, L., Eriksson, S. and Wain-Hobson, S. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. J. Virol. 1994, 68, 535-540.
-
(1994)
J. Virol.
, vol.68
, pp. 535-540
-
-
Meyerhans, A.1
Vartanian, J.-P.2
Hultgren, C.3
Plikat, U.4
Karlsson, A.5
Wang, L.6
Eriksson, S.7
Wain-Hobson, S.8
-
194
-
-
0027946446
-
Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations
-
Martinez, M.A., Vartanian, J.-P. and Wain-Hobson, S. Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations. Proc. Natl. Acad. Sci. USA 1994, 91, 11787-11791.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11787-11791
-
-
Martinez, M.A.1
Vartanian, J.-P.2
Wain-Hobson, S.3
-
195
-
-
0025977774
-
Selection, recombination, and G→A hypermutation of human immunodeficiency virus type 1 genomes
-
Vartanian, J.-P., Meyerhans, A., Åsjö, B. and Wain-Hobson, S. Selection, recombination, and G→A hypermutation of human immunodeficiency virus type 1 genomes. J. Virol. 1991, 65, 1779-1788.
-
(1991)
J. Virol.
, vol.65
, pp. 1779-1788
-
-
Vartanian, J.-P.1
Meyerhans, A.2
Åsjö, B.3
Wain-Hobson, S.4
-
196
-
-
0028180510
-
G→A hypermutation of the human immunodeficiency virus type 1 genome: Evidence for dCTP pool imbalance during reverse transcription
-
Vartanian, J.-P., Meyerhans, A., Sala, M. and Wain-Hobson, S. G→A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription. Proc. Natl. Acad. Sci. USA 1994, 91, 3092-3096.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3092-3096
-
-
Vartanian, J.-P.1
Meyerhans, A.2
Sala, M.3
Wain-Hobson, S.4
-
197
-
-
0028952146
-
HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
-
Coffin, J.M. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 1995, 267, 483-489.
-
(1995)
Science
, vol.267
, pp. 483-489
-
-
Coffin, J.M.1
-
198
-
-
0032807745
-
Manganese cations increase the mutation rate of human immunodeficiency virus type 1 ex vivo
-
Vartanian, J.-P., Sala, M., Henry, M., Wain-Hobson, S. and Meyerhans, A. Manganese cations increase the mutation rate of human immunodeficiency virus type 1 ex vivo. J. Gen. Virol. 1999, 80, 1983-1986.
-
(1999)
J. Gen. Virol.
, vol.80
, pp. 1983-1986
-
-
Vartanian, J.-P.1
Sala, M.2
Henry, M.3
Wain-Hobson, S.4
Meyerhans, A.5
-
200
-
-
0034990846
-
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
-
Balzarini, J., Camarasa, M.-J., Pérez-Pérez, M.-J., San-Félix, A., Velázquez, S., Perno, C.-F., De Clercq, E., Anderson, J.N. and Karlsson, A. Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. J. Virol. 2001, 75, 5772-5777.
-
(2001)
J. Virol.
, vol.75
, pp. 5772-5777
-
-
Balzarini, J.1
Camarasa, M.-J.2
Pérez-Pérez, M.-J.3
San-Félix, A.4
Velázquez, S.5
Perno, C.-F.6
De Clercq, E.7
Anderson, J.N.8
Karlsson, A.9
-
202
-
-
3042816120
-
Tolerance and efficacy of delavirdine mesylate (DLV) and zidovudine (ZDV) therapy in the treatment of HIV infected patients (study M/3331/013B)
-
on behalf of the M/3331:013B Study Group United Kingdom Abstracts of the 4th International Congress on Drug Therapy in HIV Infection
-
Joly V. on behalf of the M/3331:013B Study Group. 1998. Tolerance and efficacy of delavirdine mesylate (DLV) and zidovudine (ZDV) therapy in the treatment of HIV infected patients (study M/3331/013B). In Abstracts of the 4th International Congress on Drug Therapy in HIV Infection, United Kingdom.
-
(1998)
-
-
Joly, V.1
-
203
-
-
0003120693
-
Non nucleoside reverse transcriptase inhibitors
-
Joly, V. and Yeni, P. Non nucleoside reverse transcriptase inhibitors. AIDS Rev. 1999, 1, 37-44.
-
(1999)
AIDS Rev.
, vol.1
, pp. 37-44
-
-
Joly, V.1
Yeni, P.2
-
204
-
-
0028930117
-
High-dose nevirapine: Safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection
-
Havlir, D., Cheeseman, S.H., McLaughin, M., Murphy, R., Erice, A., Spector, S.A., Greenough, T.C., Sullivan, J.L., Hall, D. and Myers, M. High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. J. Infect. Dis. 1995, 171, 537-545.
-
(1995)
J. Infect. Dis.
, vol.171
, pp. 537-545
-
-
Havlir, D.1
Cheeseman, S.H.2
McLaughin, M.3
Murphy, R.4
Erice, A.5
Spector, S.A.6
Greenough, T.C.7
Sullivan, J.L.8
Hall, D.9
Myers, M.10
-
205
-
-
3042814953
-
Initial effectiveness and tolerability of nelfinavir (NFV) in combination with efavirenz (EFV, Sustiva, DMP 266) in antiretroviral therapy naïve or nucleoside analogue experience HIV-1 infected patients: Characterization in a phase II, open-label, multi-center study at > 36 weeks
-
and the DMP 266-24 Clinical Study Team San Diego, abstract I-102 38th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
Kagan, S., Jemsek, J., Martin, D.G., Pierone, G., Manion, D.J., Lee, S.R., Ruiz, N. and the DMP 266-24 Clinical Study Team. 1998. Initial effectiveness and tolerability of nelfinavir (NFV) in combination with efavirenz (EFV, Sustiva, DMP 266) in antiretroviral therapy naï ve or nucleoside analogue experience HIV-1 infected patients: characterization in a phase II, open-label, multi-center study at > 36 weeks. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, abstract I-102.
-
(1998)
-
-
Kagan, S.1
Jemsek, J.2
Martin, D.G.3
Pierone, G.4
Manion, D.J.5
Lee, S.R.6
Ruiz, N.7
-
206
-
-
3042854423
-
Cutaneous eruptions associated with nevirapine therapy in HIV-A infected individuals
-
Vancouver, no, Mo.B. 1202 Abstracts of the XI International Conference on AIDS
-
Kohlbrenner, V., Dransfield, K., Cotton, D., Robinson, P. and Myers, M. 1996. Cutaneous eruptions associated with nevirapine therapy in HIV-A infected individuals. In Abstracts of the XI International Conference on AIDS, Vancouver, no, Mo.B. 1202.
-
(1996)
-
-
Kohlbrenner, V.1
Dransfield, K.2
Cotton, D.3
Robinson, P.4
Myers, M.5
-
207
-
-
3042812653
-
A double-blind, placebo-controlled study to assess the safety, tolerability and antiretroviral activity of efavirenz in combination with open-label zidovudine and lamivudine in HIV-1 infected patients (DMP-266-004)
-
Geneva, June 28-July 3, 1998, abstract 22340 12th World AIDS Conference
-
Mayers, D., Jemesk, J., Eyster, E., Tashima, K. and Thompson, M. 1998. A double-blind, placebo-controlled study to assess the safety, tolerability and antiretroviral activity of efavirenz in combination with open-label zidovudine and lamivudine in HIV-1 infected patients (DMP-266-004). 12th World AIDS Conference, Geneva, June 28-July 3, 1998, abstract 22340.
-
(1998)
-
-
Mayers, D.1
Jemesk, J.2
Eyster, E.3
Tashima, K.4
Thompson, M.5
-
208
-
-
0003339807
-
A phase II, multicenter, randomized, open-label study to compare the antiretroviral activity and tolerability of efavirenz (EFV) + indinavir (IDV), versus EFV + zidovudine (ZDV) + lamivudine (3TC), versus IDV + ZDV + 3TC at 36 weeks (DMP 266-006)
-
and the DMP 2666-6 Clinical Study Team San Diego, California, USA, abstract I-103 38th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
Morales-Ramirez, J., Tashima, K., Hardy, D., Johnson, P., Nelson, M., Staszewski, S., Farina, D., Ruiz, N. and the DMP 2666-6 Clinical Study Team. 1998. A phase II, multicenter, randomized, open-label study to compare the antiretroviral activity and tolerability of efavirenz (EFV) + indinavir (IDV), versus EFV + zidovudine (ZDV) + lamivudine (3TC), versus IDV + ZDV + 3TC at 36 weeks (DMP 266-006). 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, California, USA, abstract I-103.
-
(1998)
-
-
Morales-Ramirez, J.1
Tashima, K.2
Hardy, D.3
Johnson, P.4
Nelson, M.5
Staszewski, S.6
Farina, D.7
Ruiz, N.8
-
209
-
-
0032554284
-
Nevirapine-associated Stevens-Johnson syndrome
-
Warren, K.J., Boxwell, D.E., Kim, N.Y. and Drolet, B.A. Nevirapine-associated Stevens-Johnson syndrome. Lancet 1998, 351, 567.
-
(1998)
Lancet
, vol.351
, pp. 567
-
-
Warren, K.J.1
Boxwell, D.E.2
Kim, N.Y.3
Drolet, B.A.4
-
210
-
-
0028900894
-
Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus
-
Cheeseman, S., Havlir, D., McLaughlin, M.M., Greenough, T.C., Sullivan, J.L., Hall, D., Hattox, S.E., Spector, S.A., Stein, D.S., Myers, M. and Richman, D.D. Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1995, 8, 141-151.
-
(1995)
J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.
, vol.8
, pp. 141-151
-
-
Cheeseman, S.1
Havlir, D.2
McLaughlin, M.M.3
Greenough, T.C.4
Sullivan, J.L.5
Hall, D.6
Hattox, S.E.7
Spector, S.A.8
Stein, D.S.9
Myers, M.10
Richman, D.D.11
-
211
-
-
16944364799
-
High-dose nevirapine in previously untreated human immunodeficiency virus type-1-infected persons does not result in sustained suppression ofviral replication
-
De Jong, M., S. Vella, A. Carr, et al.. High-dose nevirapine in previously untreated human immunodeficiency virus type-1-infected persons does not result in sustained suppression ofviral replication. J. Infect Dis. 1997, 175, 966-970.
-
(1997)
J. Infect. Dis.
, vol.175
, pp. 966-970
-
-
De Jong, M.1
Vella, S.2
Carr, A.3
-
212
-
-
8944232862
-
Randomized, controlled phase I/II trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients
-
Davey, R.T Jr., Chaitt, D.G., Reed, G.F., Freimuth, W.W., Herpin, B.R., Metcalf, J.A., Eastman, P.S., Falloon, J., Kovacs, J.A., Polis, M.A., Walker, R.E., Masur, H., Boyle, J., Coleman, S., Cox, S.R., Wathen, L., Daenzer, C.L. and Lane, H.C. Randomized, controlled phase I/II trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients. Antimicrob. Agents Chemother 1996, 40, 1657-1664.
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 1657-1664
-
-
Davey Jr., R.T.1
Chaitt, D.G.2
Reed, G.F.3
Freimuth, W.W.4
Herpin, B.R.5
Metcalf, J.A.6
Eastman, P.S.7
Falloon, J.8
Kovacs, J.A.9
Polis, M.A.10
Walker, R.E.11
Masur, H.12
Boyle, J.13
Coleman, S.14
Cox, S.R.15
Wathen, L.16
Daenzer, C.L.17
Lane, H.C.18
-
213
-
-
0030990223
-
Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection
-
Luzuriaga, K., Bryson, Y., Krogstad, P., Robinson, J., Stechenberg, B., Lamson, M., Cort, S. and Sullivan, J.L. Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection. New Engl. J. Med. 1997, 336, 1343-1349.
-
(1997)
New Engl. J. Med.
, vol.336
, pp. 1343-1349
-
-
Luzuriaga, K.1
Bryson, Y.2
Krogstad, P.3
Robinson, J.4
Stechenberg, B.5
Lamson, M.6
Cort, S.7
Sullivan, J.L.8
-
214
-
-
0032565098
-
A randomized, double-blind trial comparing combinations of nevirapine, didanosine and zidovudine for HIV-infected patients. The INCAS trial
-
151
-
Montaner, J., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., Wainberg, M.A., Smith, D., Robinson, P., Hall, D., Myers, M. and Lange, J.M. A randomized, double-blind trial comparing combinations of nevirapine, didanosine and zidovudine for HIV-infected patients. The INCAS trial. JAMA 1998, 279, 930-937.151.
-
(1998)
JAMA
, vol.279
, pp. 930-937
-
-
Montaner, J.1
Reiss, P.2
Cooper, D.3
Vella, S.4
Harris, M.5
Conway, B.6
Wainberg, M.A.7
Smith, D.8
Robinson, P.9
Hall, D.10
Myers, M.11
Lange, J.M.12
-
215
-
-
0006940622
-
Sustained plasma viral burden reductions and CD4 increases in HIV-1-infected patients with rescriptor plus retrovir plus epivir
-
Chicago, Illinois, USA, abstract no. 699 5th Conference on Retroviruses and Opportunistic Infections
-
Sargent, S., Green, S., Para, M., Freimuth, W., Wahren, L., Getchel, L. and Greenwald, C. 1998. Sustained plasma viral burden reductions and CD4 increases in HIV-1-infected patients with rescriptor plus retrovir plus epivir. 5th Conference on Retroviruses and Opportunistic Infections, Chicago, Illinois, USA, abstract no. 699.
-
(1998)
-
-
Sargent, S.1
Green, S.2
Para, M.3
Freimuth, W.4
Wahren, L.5
Getchel, L.6
Greenwald, C.7
-
216
-
-
0032581593
-
Clinical experience with adding delavirdine to combination therapy in patients in whom multiple antiretroviral treatment including protease inhibitors has failed
-
Bellman, P. Clinical experience with adding delavirdine to combination therapy in patients in whom multiple antiretroviral treatment including protease inhibitors has failed. AIDS 1998, 12, 1333-1340.
-
(1998)
AIDS
, vol.12
, pp. 1333-1340
-
-
Bellman, P.1
-
217
-
-
0026318387
-
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
-
Richman, D., Shih, C.-K., Lowy, I., Rose, J., Prodanovich, P., Goff, S. and Griffin, J. Human immunodeficiency virus type 1 mutants resistant t o nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc. Natl. Acad. Sci. 1991, 88, 11241-11245.
-
(1991)
Proc. Natl. Acad. Sci.
, vol.88
, pp. 11241-11245
-
-
Richman, D.1
Shih, C.-K.2
Lowy, I.3
Rose, J.4
Prodanovich, P.5
Goff, S.6
Griffin, J.7
-
218
-
-
0028898824
-
Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high level resistance to L-697,661, a non-nucleoside reverse transcriptase inhibitor
-
Staszewski, S., Massari, F.E., Kober, A., Gohler, R., Durr, S., Anderson, K.W., Schneider, C.L., Waterbury, J.A., Bakshi, K.K., Taylor, V.I., Hildebrand, C.S., Kreisl, C., Hoffstedt, B., Schleif, W.A., von Briesen, H., Rübsamen-Waigmann, H., Calandra, G.B., Ryan, J.L., Stille, W., Emini, E.A., and Byrnes, V.W. Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high level resistance to L-697,661, a non-nucleoside reverse transcriptase inhibitor. J. Infect. Dis. 1995, 171, 159-165.
-
(1995)
J. Infect. Dis.
, vol.171
, pp. 159-165
-
-
Staszewski, S.1
Massari, F.E.2
Kober, A.3
Gohler, R.4
Durr, S.5
Anderson, K.W.6
Schneider, C.L.7
Waterbury, J.A.8
Bakshi, K.K.9
Taylor, V.I.10
Hildebrand, C.S.11
Kreisl, C.12
Hoffstedt, B.13
Schleif, W.A.14
von Briesen, H.15
Rübsamen-Waigmann, H.16
Calandra, G.B.17
Ryan, J.L.18
Stille, W.19
Emini, E.A.20
Byrnes, V.W.21
more..
-
219
-
-
3042856683
-
Delavirdine (DLV) susceptibility of HIV-1 isolates obtained from patients receiving DLV monotherapy
-
USA Abstracts of the 3rd Conference on Retroviruses and Opportunistic Infections
-
Demeter, L., Shafer, R., Para, M. et al. 1996. Delavirdine (DLV) susceptibility of HIV-1 isolates obtained from patients receiving DLV monotherapy. In Abstracts of the 3rd Conference on Retroviruses and Opportunistic Infections. USA.
-
(1996)
-
-
Demeter, L.1
Shafer, R.2
Para, M.3
-
220
-
-
0342629401
-
Analysis of 5000 HIV-1 clinical samples reveals complex non-nucleoside RT inhibitor resistance patterns
-
Resistance Workshop, San Diego, California, USA, 23-26 June 1999
-
Kemp, S., Bloor, S. Van Cauwenberghe, A., De Koning, I., Van den Eynde, C., Larder, B. and Hertogs, K. 1999. Analysis of 5000 HIV-1 clinical samples reveals complex non-nucleoside RT inhibitor resistance patterns. Resistance Workshop, San Diego, California, USA, 23-26 June 1999. Antiviral Therapy, 4, suppl. 1, p. 20, no. 26.
-
(1999)
Antiviral Therapy
, vol.4
, Issue.26 SUPPL. 1
, pp. 20
-
-
Kemp, S.1
Bloor, S.2
Van Cauwenberghe, A.3
De Koning, I.4
Van den Eynde, C.5
Larder, B.6
Hertogs, K.7
-
221
-
-
84884419717
-
A syndrome of peripheral lipodystrophy, hyperlipidemia and insulin resistance due to HIV protease inhibitors
-
Chicago, Illinois, USA no. 410 Abstracts of the 5th Conference on Retroviruses an Opportunistic Infections
-
Carr, A., Samaras, K., Burton, S., Freund, J., Chisholm, D.J. and Cooper, D.A. A syndrome of peripheral lipodystrophy, hyperlipidemia and insulin resistance due to HIV protease inhibitors. In Abstracts of the 5th Conference on Retroviruses an Opportunistic Infections, Chicago, Illinois, USA, 1998, no. 410.
-
(1998)
-
-
Carr, A.1
Samaras, K.2
Burton, S.3
Freund, J.4
Chisholm, D.J.5
Cooper, D.A.6
-
222
-
-
0030997133
-
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: Retrovirucidal activity of UC-781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
-
Borkow, G, Barnard, J., Nguyen, T.M., Belmonte, A., Wainberg, M.A., and Parniak, M.A. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC-781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. J. Virol. 1997, 71, 3023-3030.
-
(1997)
J. Virol.
, vol.71
, pp. 3023-3030
-
-
Borkow, G.1
Barnard, J.2
Nguyen, T.M.3
Belmonte, A.4
Wainberg, M.A.5
Parniak, M.A.6
-
223
-
-
0030751673
-
The thiocarboxanilide nonnucleoside UC-781 is a tight-binding inhibitor of HIV-1 reverse transcriptase
-
Barnard, J., Borkow, G. and Parniak, M.A. The thiocarboxanilide nonnucleoside UC-781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Biochemistry 1997, 36, 7786-7792.
-
(1997)
Biochemistry
, vol.36
, pp. 7786-7792
-
-
Barnard, J.1
Borkow, G.2
Parniak, M.A.3
-
224
-
-
0032500021
-
Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent
-
Balzarini, J., Naesens, L., Verbeken, E., Laga, M., Van Damme, L., Parniak, M., Van Mellaert, L., Anné, J. and De Clercq, E. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS 1998, 12, 1129-1138.
-
(1998)
AIDS
, vol.12
, pp. 1129-1138
-
-
Balzarini, J.1
Naesens, L.2
Verbeken, E.3
Laga, M.4
Van Damme, L.5
Parniak, M.6
Van Mellaert, L.7
Anné, J.8
De Clercq, E.9
|