Pyrimidine thioethers: A novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV

Journal of Medicinal Chemistry

Volumn 41, Issue 20, 1998, Pages 3793-3803

  Nugent, Richard A ^a   Schlachter, Stephen T ^a   Murphy, Michael J ^a   Cleek, Gary J ^a   Poel, Toni J ^a   Wishka, Donn G ^a   Graber, David R ^a   Yagi, Yoshihiko ^a   Keiser, Barbara J ^a   Olmsted, Robert A ^a   Kopta, Laurie A ^a   Swaney, Steven M ^a   Poppe, Susan M ^a   Morris, Joel ^a   Tarpley, W Gary ^a   Thomas, Richard C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DELAVIRDINE; N,N DIETHYL 4 [(4 AMINO 6 CHLORO 2 PYRIMIDINYL)THIO] 2 BUTENAMIDE; N,N DIMETHYL 4 [(4 AMINO 6 CHLORO 2 PYRIMIDINYL)THIO] 2 BUTENAMIDE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-HIV AGENTS; CELL LINE; DELAVIRDINE; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; LEUCINE; MICE; PROLINE; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 14444278270     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800806     Document Type: Article

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