Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 16, 1996, Pages 3217-3227

  Cushman, Mark ^a   Golebiewski, W Marek ^a   Graham, Lisa ^b   Turpin, Jim A ^b   Rice, William G ^b   Fliakas Boltz, Valerie ^c   Buckheit Jr , Robert W ^c  

^a PURDUE UNIVERSITY   (United States)

^b SAIC FREDERICK INC   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS ENZYME; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CROSS RESISTANCE; DRUG CONFORMATION; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; AURINTRICARBOXYLIC ACID; BENZOATES; BINDING SITES; BIPHENYL COMPOUNDS; CELLS, CULTURED; DIDANOSINE; DRUG RESISTANCE, MICROBIAL; HIV CORE PROTEIN P24; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE;

EID: 0029783936     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960082v     Document Type: Article

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