Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-{spiro[4'-amino-2',2'-dioxo- 1',2'-oxathiole-5',3'- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]]}-3-ethylthymine

Biochemistry

Volumn 39, Issue 6, 2000, Pages 1427-1433

  Sluis Cremer, Nicolas ^a   Dmitrienko, Gary I ^b   Balzarini, Jan ^c   Camarasa, Maria José ^d   Parniak, Michael A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2',5' BIS O (TERT BUTYLDIMETHYLSILYL)] 3' SPIRO 5' (4' AMINO 1',2' OXATHIOLE 2',2' DIOXIDE) 3 ETHYLTHYMINE; 1 [SPIRO[4' AMINO 2',2' DIOXO 1',2' OXATHIOLE 5',3' [2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA RIBOFURANOSYL]]] 3 ETHYLTHYMINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBUNIT; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

ANILIDES; ANTI-HIV AGENTS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMERIZATION; ENZYME ACTIVATION; ENZYME STABILITY; FURANS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; NEVIRAPINE; PROTEIN DENATURATION; REVERSE TRANSCRIPTASE INHIBITORS; SPIRO COMPOUNDS; THYMIDINE; UREA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034673154     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991682+     Document Type: Article

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