Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3- and 4-substituted derivatives

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 1034-1040

  Genin, Michael J ^a   Biles, Carolyn ^a   Keiser, Barb J ^c   Poppe, Susan M ^b   Swaney, Steven M ^b   Tarpley, W Gary ^b   Yagi, Yoshihiko ^c   Romero, Donna L ^a  

^a Medicinal Chemistry Research   (United States)

^b Infectious Diseases Research   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 4 CYANOMETHYL 3 METHYL 1,5 DIPHENYLPYRAZOLE; DELAVIRDINE; PYRAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG RESISTANCE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; DELAVIRDINE; DRUG RESISTANCE, MICROBIAL; HIV-1 REVERSE TRANSCRIPTASE; MUTATION; PYRAZOLES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034624679     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990383f     Document Type: Article

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