Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 8, 1997, Pages 3984-3989

  Esnouf, Robert M ^a,b,c   Ren, Jingshan ^a   Hopkins, Andrew L ^a   Ross, Carl K ^d   Jones, E Yvonne ^a,b   Stammers, David K ^a,d   Stuart, David I ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

AIDS; delavirdine; drug design; x ray crystallography

Indexed keywords

DELAVIRDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COMPLEX FORMATION; CROSS RESISTANCE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; GENE MUTATION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

HIV 1; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030935265     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.8.3984     Document Type: Article

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