2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1

Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2001, Pages 1866-1882

  Chan, J H ^a   Hong, J S ^a,b   Hunter III, R N ^a   Orr, G F ^a   Cowan, J R ^a   Sherman, D B ^a,c   Sparks, S M ^a,d   Reitter, B E ^a   Andrews III, C W ^a   Hazen, R J ^a   St Clair, M ^a   Boone, L R ^a   Ferris, R G ^a   Creech, K L ^a   Roberts, G B ^a   Short, S A ^a   Weaver, K ^a   Ott, R J ^a   Ren, J ^a,e   Hopkins, A ^a,e   Stuart, D I ^a,e,f   Stammers, D K ^a,e,f   more..

^a GLAXOSMITHKLINE   (United States)

^b SCYNEXIS Inc   (United States)

^c BD Technologies   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZONITRILE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFONE; SULFOXIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS STRAIN; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE, TRANSFORMED; CRYSTALLOGRAPHY, X-RAY; HIV-1 REVERSE TRANSCRIPTASE; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NITRILES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 0035821597     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0004906     Document Type: Article

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