(-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4- pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1357-1360

  Wishka, D G ^a   Graber, D R ^a   Kopta, L A ^a   Olmsted, R A ^a   Friis, J M ^a   Hosley, J D ^a   Adams, W J ^a   Seest, E P ^a   Castle, T M ^a   Dolak, L A ^a   Keiser, B J ^a   Yagi, Y ^a   Jeganathan, A ^a   Schlachter, S T ^a   Murphy, M J ^a   Cleek, G J ^a   Nugent, R A ^a   Poppe, S M ^a   Swaney, S M ^a   Han, F ^a   Watt, W ^a   White, W L ^a   Poel, T J ^a   Thomas, R C ^a   Voorman, R L ^a   Stefanski, K J ^a   Stehle, R G ^a   Tarpley, W G ^a   Morris, J ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 6 CHLORO 2[(1 FURO[2,3 C]PYRIDIN 5 YL ETHYL)THIO] 4 PYRIMIDAMINE; DELAVIRDINE; PIPERAZINE DERIVATIVE; R 88703; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG RESISTANCE; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; LETTER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MALE; MUTATION; PYRIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM;

EID: 0032560237     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801049     Document Type: Letter

References (17)