3,3a-dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 211-214

  Corbett, Jeffrey W ^a   Pan, Senliang ^a   Markwalder, Jay A ^a   Cordova, Beverly C ^a   Klabe, Ronald M ^a   Garber, Sena ^a   Rodgers, James D ^a   Erickson Viitanen, Susan K ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2A,5 DIHYDRO 2H THIENO[4,3,2 DE]QUINAZOLINE 4(3H) THIONE; 3,3A DIHYDROPYRANO[4,3,2 DE]QUINAZOLIN 2(1H) ONE DERIVATIVE; 6 CHLORO 4 (2 CYCLOPROPYLVINYL) 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 6 CHLORO 4 CYCLOPROPYLETHYNYL 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG RESISTANCE; HETEROCYCLIC COMPOUNDS, 2-RING; HETEROCYCLIC COMPOUNDS, 3-RING; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; POINT MUTATION; PYRANS; QUINAZOLINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035931438     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00624-7     Document Type: Article

References (19)