Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 → Val or Ile and Val-75 → Leu or Ile) HIV-1 mutants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 34-38

  Kleim, Jörg Peter ^a   Rösner, Manfred ^a   Winkler, Irvin ^a   Paessens, Arno ^b   Kirsch, Reinhard ^a   Hsiou, Yu ^c   Arnold, Edward ^c   Riess, Günther ^a  

^a SANOFI   (France)

^b BAYER AG   (Germany)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE; 3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 6 CHLORO 3,4 DIHYDRO 4 (ISOPROPENYLOXYCARBONYL) 3,3 DIMETHYL 2(1H) QUINOXALINETHIONE; DELAVIRDINE; DIDANOSINE; NEVIRAPINE; QUINOXALINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; S 2720; STAVUDINE; TALVIRALINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS MUTANT; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN;

ANTIVIRAL AGENTS; BASE SEQUENCE; DNA PRIMERS; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MOLECULAR SEQUENCE DATA; MUTATION; QUINOXALINES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; SELECTION (GENETICS); VIRUS REPLICATION;

EID: 0030070683     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.34     Document Type: Article

References (28)

1. Larder, B. A. & Kemp, S. D. (1989) Science 246, 1155-1158.
2. St. Clair, M. H., Martin, J. L., Tudor-Williams, G., Bach, M. C., Vavro, C. L., King, D. M., Kellam, P., Kemp, S. D. & Larder, B. A. (1991) Science 253, 1557-1559.
3. Kellam, P., Boucher, C. A. B. & Larder, B. A. (1992) Proc. Natl. Acad. Sci. USA 89, 1934-1938.
4. Tisdale, M., Kemp, S. D., Parry, N. R. & Larder, B. A. (1993) Proc. Natl. Acad. Sci. USA 90, 5653-5656.
5. Gu, Z., Gao, Q., Fang, H., Salomon, H., Parniak, M. A., Goldberg, E., Cameron, J. & Wainberg, M. A. (1994) Antimicrob. Agents Chemother. 38, 275-281.
6. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A. & Steitz, T. A. (1992) Science 256, 1783-1790.
7. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H. & Arnold, E. (1993) Proc. Natl. Acad. Sci. USA 90, 6320-6324.
8. Boyer, P. L., Tantillo, C., Jacobo-Molina, A., Nanni, R. G., Ding, J., Arnold, E. & Hughes, S. H. (1994) Proc. Natl. Acad. Sci. USA 91, 4882-4886.
9. Nunberg, J. H., Schleif, W. A., Boots, E. J., O'Brien, J. A., Quintero, J. C., Hoffman, J. M., Emini, E. A. & Goldman, M. E. (1991) J. Virol. 65, 4887-4892.
10. Richman, D., Shih, C. K., Lowy, I., Rose, J., Prodanovich, P., Goff, S. & Griffin, J. (1991) Proc. Natl. Acad. Sci. USA 88, 11241-11245.
11. Balzarini, J., Karlsson, A., Pérez-Pérez, M. J., Vrang, L., Walbers, J., Zhang, H., Öberg, B., Vandamme, A. M., Camarasa, M. J. & De Clercq, E. (1993) Virology 192, 246-253.
12. Balzarini, J., Karlsson, A., Pérez-Pérez, M. J., Camarasa, M. J., Tarpley, W. G. & De Clercq, E. (1993) J. Virol. 67, 5353-5359.
13. Byrnes, V. W., Sardana, V. V., Schleif, W. A., Condra, J. H., Waterbury, J. A., Wolfgang, J. A., Long, W. J., Schneider, C. L., Schlabach, A. J., Wolanski, B. S., Graham, D. J., Gotlib, L., Rhodes, A., Titus, D. L., Roth, E., Blahy, O. M., Quintero, J. C., Staszewski, S. & Emini, E. A. (1993) Antimicrob. Agents Chemother. 37, 1576-1579.
14. Dueweke, T. J., Pushkarskaya, T., Poppe, S. M., Swaney, S. M., Zhao, J. Q., Chen, I. S. Y., Stevenson, M. & Tarpley, W. G. (1993) Proc. Natl. Acad. Sci. USA 90, 4713-4717.
15. Richman, D. D., Havlir, D., Corbeil, J., Looney, D., Ignacio, C., Spector, S. A., Sullivan, J., Cheeseman, S., Barringer, K., Pauletti, D., Shih, C. K., Myers, M. & Griffin, J. (1994) J. Virol. 68, 1660-1666.
16. Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., Saag, M. S. & Shaw, G. M. (1995) Nature (London) 373, 117-122.
17. Kleim, J. P., Bender, R., Billhardt, U. M., Meichsner, C., Rieß, G., Rösner, M., Winkler, I. & Paessens, A. (1993) Antimicrob. Agents Chemother. 37, 1659-1664.
18. Balzarini, J., Karlsson, A., Meichsner, C., Paessens, A., Riess, G., De Clercq, E. & Kleim, J. P. (1994) J. Virol. 68, 7986-7992.
19. Kleim, J. P., Bender, R., Kirsch, R., Meichsner, C., Paessens, A. & Riess, G. (1994) Virology 200, 696-701.
20. Smerdon, S. J., Jäger, J., Wang, J., Kohlstaedt, L. A., Chirino, A. J., Friedman, M., Rice, P. A. & Steitz, T. A. (1994) Proc. Natl. Acad. Sci. USA 91, 3911-3915.
21. Ding, J., Das, K., Tantillo, C., Zhang, W., Clark, A. D., Jessen, S., Lu, X., Hsiou, Y., Jacobo-Molina, A., Andries, K., Pauwels, R., Moereels, H., Koymans, L., Janssen, P. A. J., Smith, R. H., Koepke, M. K., Michejda, C. J., Hughes, S. H. & Arnold, E. (1995) Structure 3, 365-379.
22. Kleim, J.-P., Bender, R., Kirsch, R., Meichsner, C., Paessens, A., Rösner, M., Rübsamen-Waigmann, H., Kaiser, R., Wichers, M., Schneweis, K. E., Winkler, I. & Riess, G. (1995) Antimicrob. Agents Chemother. 39, 2253-2257.
23. Albert, J., Wahlberg, J., Leitner, T., Escanilla, D. & Uhlen, M. (1994) J. Virol. 68, 5918-5924.
24. Chao, S.-F., Loong Chan, V., Juranka, P., Kaplan, A. H., Swanstrom, R. & Hutchison, C. A. (1995) Nucleic Acids Res. 23, 803-810.
25. Boyer, P. L., Ferris, A. L., Clark, P., Whitmer, J., Frank, P., Tantillo, C., Arnold, E. & Hughes, S. H. (1994) J. Mol. Biol. 243, 472-483.
26. Mellors, J. W., Bazmi, H. Z., Schinazi, R. F., Roy, B. M., Hsiou, Y., Arnold, E., Weir, J. & Mayers, D. L. (1995) Antimicrob. Agents Chemother. 39, 1087-1092.
27. Shafer, R. W., Kozal, M. J., Winters, M. A., Iversen, A. K. N., Katzenstein, D. A., Ragni, M. V., Meyer, W. A., Gupta, P., Rasheed, S., Coombs, R., Katzman, M., Fiscus, S. & Merigan, T. C. (1994) J. Infect. Dis. 169, 722-729.
28. Shirasaka, T., Kavlick, M. F., Ueno, T., Gao, W.-Y., Kojima, E., Alcaide, M. L., Chokekijchai, S., Roy, B. M., Arnold, E., Yarchoan, R. & Mitsuya, H. (1995) Proc. Natl. Acad. Sci. USA 92, 2398-2402.