4,1-Benzoxazepinone analogues of efavirenz (Sustiva™) as HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 11, 2001, Pages 1389-1392

  Cocuzza, Anthony J ^a   Chidester, Dennis R ^a   Cordova, Beverly C ^a   Klabe, Ronald M ^a   Jeffrey, Susan ^a   Diamond, Sharon ^a   Weigelt, Carolyn A ^a   Ko, Soo S ^a   Bacheler, Lee T ^a   Erickson Viitanen, Susan K ^a   Rodgers, James D ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 CYCLOPROPYLVINYL) 5,6 DIFLUORO 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 4 CYCLOPROPYLETHYNYL 5,6 DIFLUORO 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 4,1 BENZOXAZEPINONE DERIVATIVE; 6 CHLORO 4 (2 CYCLOPROPYLVINYL) 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 6 CHLORO 4 CYCLOPROPYLETHYNYL 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; AZEPINE DERIVATIVE; EFAVIRENZ; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOMER; NONHUMAN; PROTEIN BINDING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANIMALS; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MACACA MULATTA; OXAZINES; PROTEIN BINDING; QUINAZOLINES; QUINAZOLINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035806181     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00239-6     Document Type: Article

References (16)

1. The SUSTIVA resistance study team