Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses

Journal of Biological Chemistry

Volumn 275, Issue 8, 2000, Pages 5633-5639

  Ren, Jingshan ^a   Diprose, Jonathan ^a   Warren, Jonathan ^a   Esnouf, Robert M ^a   Bird, Louise E ^a   Ikemizu, Shinji ^a   Slater, Martin ^b   Milton, John ^b   Balzarini, Jan ^c   Stuart, David I ^a,d   Stammers, David K ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE; THIOUREA DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DNA TEMPLATE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; PRIORITY JOURNAL; PROTEIN ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DEOXYGUANINE NUCLEOTIDES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1 REVERSE TRANSCRIPTASE; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PYRIDINES; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; THIAZOLES; THIOUREA; TRIAZOLES;

EID: 0034053131     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.8.5633     Document Type: Article

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