Crystal structures of zidovudine- or lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215

Journal of Virology

Volumn 76, Issue 19, 2002, Pages 10015-10019

  Chamberlain, P P ^a   Ren, J ^a   Nichols, C E ^a   Douglas, L ^a   Lennerstrand, J ^a   Larder, B A ^a   Stuart, D I ^a   Stammers, D K ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS DNA; ZIDOVUDINE;

ARTICLE; CHEMICAL REACTION; CODON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; GENE MUTATION; GENE STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MODEL; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; VIRUS GENE;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; CODON; CRYSTALLIZATION; DRUG RESISTANCE, VIRAL; HIV-1 REVERSE TRANSCRIPTASE; LAMIVUDINE; MUTATION; PROTEIN CONFORMATION; ZIDOVUDINE;

EID: 0036776359     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.19.10015-10019.2002     Document Type: Article

References (24)

1. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
2. Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
3. Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not
4. Crystallography and NMR system: A new software suite for macromolecular structure determination
5. Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration
6. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
7. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA
8. Improved methods for building protein models in electron density maps and the location of errors in these models
9. Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance
10. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
11. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
12. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
13. Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants
14. A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
15. Processing of X-ray diffraction data collected in oscillation mode
16. High resolution structures of HIV-1 RT from four RT-inhibitor complexes
17. 3′-azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce-long range conformational changes
18. Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives
19. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids
20. Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
21. Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs)
22. Crystals of HIV-1 reverse transcriptase diffracting to 2.2 Å resolution
23. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
24. Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous