Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 22, 2002, Pages 14410-14415

  Ren, J ^a   Bird, L E ^a   Chamberlain, P P ^a,b   Stewart Jones, G B ^a   Stuart, D I ^a,b   Stammers, D K ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

AIDS; Crystallography; Drug resistance; Polymerase

Indexed keywords

RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SEROTYPE; STRUCTURE ANALYSIS; VIRUS RESISTANCE;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; RNA VIRUSES;

EID: 0037195081     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.222366699     Document Type: Article

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