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Volumn 13, Issue 8, 1997, Pages 695-705

Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents

Author keywords

[No Author keywords available]

Indexed keywords

1506; 1737; 1738; 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; 5,6,7 TRIMETHOXY 4 (3,4,5 TRIMETHOXYPHENYL) 1,3,3A,4,9,9A HEXAHYDRONAPHTHO[2,3 C]THIOPHENE; 7 METHOXY 5,6 METHYLENEDIOXY 4 (4 BENZYLOXY 3 METHOXYPHENYL) 1,3,3A,4,9,9A HEXAHYDRONAPHTHO[2,3 C]THIOPHENE; ANTIVIRUS AGENT; FOSCARNET; GOMISIN; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 0030992580     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1997.13.695     Document Type: Article
Times cited : (45)

References (64)
  • 2
    • 0021237243 scopus 로고
    • Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    • Popovic M, Sarngadharan MG, Read E, and Gallo RC: Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984;224:497-500.
    • (1984) Science , vol.224 , pp. 497-500
    • Popovic, M.1    Sarngadharan, M.G.2    Read, E.3    Gallo, R.C.4
  • 3
    • 0026523623 scopus 로고
    • HIV inhibitors targeted at the reverse transcriptase
    • De Clercq E: HIV inhibitors targeted at the reverse transcriptase. AIDS Res Hum Retroviruses 1992;8:119-134.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 119-134
    • De Clercq, E.1
  • 4
    • 0001707601 scopus 로고
    • 3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
    • Mitsuya H, Weinhold KJ, Furman PA, St. Clair MH, Nusinoff-Lehrman S, Gallo RC, Bolognesi D, Barry DW, and Broder S: 3′-Azido-3′-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci USA 1985;82:7096-7100.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3    St. Clair, M.H.4    Nusinoff-Lehrman, S.5    Gallo, R.C.6    Bolognesi, D.7    Barry, D.W.8    Broder, S.9
  • 7
    • 0023109808 scopus 로고
    • Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders: A progress report
    • Yarchoan R and Broder S: Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders: a progress report. N Engl J Med 1987;316:557-564.
    • (1987) N Engl J Med , vol.316 , pp. 557-564
    • Yarchoan, R.1    Broder, S.2
  • 9
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA and Kemp SD: Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 1989;246:1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 14
    • 0026324187 scopus 로고
    • Anti-HIV agents. I. Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-(a)]benzimidazoles
    • Chimirri A, Grasso S, Monforte A-M, Monforte P, and Zappala M: Anti-HIV agents. I. Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-(a)]benzimidazoles. Farmaco 1991;46: 817-823.
    • (1991) Farmaco , vol.46 , pp. 817-823
    • Chimirri, A.1    Grasso, S.2    Monforte, A.-M.3    Monforte, P.4    Zappala, M.5
  • 15
    • 0025812546 scopus 로고
    • Anti-HIV agents. II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-(a)]benzimidazoles
    • Chimirri A, Grasso S, Monforte A-M, Monforte P, and Zappala M: Anti-HIV agents. II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-(a)]benzimidazoles. Farmaco 1991;46: 925-933.
    • (1991) Farmaco , vol.46 , pp. 925-933
    • Chimirri, A.1    Grasso, S.2    Monforte, A.-M.3    Monforte, P.4    Zappala, M.5
  • 20
    • 0026773419 scopus 로고
    • Generation of nucleoside-resistant variants for HIV-1 by in vitro selection in the presence of AZT of DDI but not by combinations
    • Gao Q, Parniak MA, Gu Z, and Wainberg MA: Generation of nucleoside-resistant variants for HIV-1 by in vitro selection in the presence of AZT of DDI but not by combinations. Leukemia 1993;6:192S-195S.
    • (1993) Leukemia , vol.6
    • Gao, Q.1    Parniak, M.A.2    Gu, Z.3    Wainberg, M.A.4
  • 22
    • 0027424829 scopus 로고
    • Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents
    • Buckheit RW, Germany-Decker J, Hollingshead MG, Allen LB, Shannon WM, Janssen PAJ, and Chirigos MA: Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents. AIDS Res Hum Retroviruses 1993;9:1097-1106.
    • (1993) AIDS Res Hum Retroviruses , vol.9 , pp. 1097-1106
    • Buckheit, R.W.1    Germany-Decker, J.2    Hollingshead, M.G.3    Allen, L.B.4    Shannon, W.M.5    Janssen, P.A.J.6    Chirigos, M.A.7
  • 23
    • 0026701152 scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) inhibitory interactions between protease inhibitor Ro 31-8959 and zidovudine, 2′,3′-dideoxycytidine, or recombinant interferon-αA against zidovudine-sensitive or -resistant HIV-1 in vitro
    • Johnson VA, Merrill DP, Chou T-C, and Hirsch MS: Human immunodeficiency virus type 1 (HIV-1) inhibitory interactions between protease inhibitor Ro 31-8959 and zidovudine, 2′,3′-dideoxycytidine, or recombinant interferon-αA against zidovudine-sensitive or -resistant HIV-1 in vitro. J Infect Dis 1992;166: 1143-1146.
    • (1992) J Infect Dis , vol.166 , pp. 1143-1146
    • Johnson, V.A.1    Merrill, D.P.2    Chou, T.-C.3    Hirsch, M.S.4
  • 24
    • 0018742295 scopus 로고
    • Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly
    • Brewer CF, Loike JD, Horwitz SB, Sternlicht H, and Gensler WJ: Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly. J Med Chem 1979;22:215-221.
    • (1979) J Med Chem , vol.22 , pp. 215-221
    • Brewer, C.F.1    Loike, J.D.2    Horwitz, S.B.3    Sternlicht, H.4    Gensler, W.J.5
  • 25
    • 0017046968 scopus 로고
    • Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells
    • Loike JD and Horwitz SB: Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells. Biochemistry 1976;15: 5443-5448.
    • (1976) Biochemistry , vol.15 , pp. 5443-5448
    • Loike, J.D.1    Horwitz, S.B.2
  • 29
    • 0025829325 scopus 로고
    • Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase
    • Higuchi H, Mori K, Kato A, Ohkuma T, Endo T, Kaji H, and Kaji A: Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res 1991;15:205-216.
    • (1991) Antiviral Res , vol.15 , pp. 205-216
    • Higuchi, H.1    Mori, K.2    Kato, A.3    Ohkuma, T.4    Endo, T.5    Kaji, H.6    Kaji, A.7
  • 31
    • 0028110846 scopus 로고
    • Short, terminally phosphorylated oligoriboguanylic acids effectively inhibit cytopathicity caused by human immunodeficiency virus
    • Fujihashi T, Sakata T, Kaji A, and Kaji H: Short, terminally phosphorylated oligoriboguanylic acids effectively inhibit cytopathicity caused by human immunodeficiency virus. Biochem Biophys Res Commun 1994;203:1244-1250.
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1244-1250
    • Fujihashi, T.1    Sakata, T.2    Kaji, A.3    Kaji, H.4
  • 32
    • 0029024338 scopus 로고
    • Antiviral action of oligodeoxyguanylic acids against human immunodeficiency virus-1
    • Fujihashi T, Sakata T, Kaji A, and Kaji H: Antiviral action of oligodeoxyguanylic acids against human immunodeficiency virus-1. AIDS Res Hum Retroviruses 1995;11:461-471.
    • (1995) AIDS Res Hum Retroviruses , vol.11 , pp. 461-471
    • Fujihashi, T.1    Sakata, T.2    Kaji, A.3    Kaji, H.4
  • 33
    • 0029088913 scopus 로고
    • Anti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptase
    • Fujihashi T, Hara H, Sakata T, Mori K, Higuchi H, Tanaka A, Kaji H, and Kaji A: Anti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptase. Antimicrob Agents Chemother 1995;39:2000-2007.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2000-2007
    • Fujihashi, T.1    Hara, H.2    Sakata, T.3    Mori, K.4    Higuchi, H.5    Tanaka, A.6    Kaji, H.7    Kaji, A.8
  • 34
    • 85036448853 scopus 로고    scopus 로고
    • Tetrahydronaphthalene derivative, process for producing the same, and retrovirus infection remedy containing the same as active ingredient. International Patent PCTJP94 01083 (WO9501950), 1994
    • Tanaka M, Sakata T, Ikeya Y, Wakamatsu T, Fujihashi T, Kaji A, and Kaji H: Tetrahydronaphthalene derivative, process for producing the same, and retrovirus infection remedy containing the same as active ingredient. International Patent PCTJP94 01083 (WO9501950), 1994.
    • Tanaka, M.1    Sakata, T.2    Ikeya, Y.3    Wakamatsu, T.4    Fujihashi, T.5    Kaji, A.6    Kaji, H.7
  • 35
    • 0022404296 scopus 로고
    • Infection of HTLV-III/LAV in HTLV-1-carrying cells MT-2 and MT-4 and application in a plaque assay
    • Harada S, Koyanagi Y, and Yamamoto N: Infection of HTLV-III/LAV in HTLV-1-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 1985;229:563-566.
    • (1985) Science , vol.229 , pp. 563-566
    • Harada, S.1    Koyanagi, Y.2    Yamamoto, N.3
  • 36
    • 0021719086 scopus 로고
    • Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines
    • Smith SD, Shatsky M, Cohen PS, Warnke R, Link MP, and Glader BE: Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines. Cancer Res 1984;44:5657-5660.
    • (1984) Cancer Res , vol.44 , pp. 5657-5660
    • Smith, S.D.1    Shatsky, M.2    Cohen, P.S.3    Warnke, R.4    Link, M.P.5    Glader, B.E.6
  • 38
    • 0025093306 scopus 로고
    • Biological and molecular variability of human immunodeficiency virus type 2 isolates from the Gambia
    • Schulz TF, Whitby D, Hoad JG, Corrah T, Whittle H, and Weiss RA: Biological and molecular variability of human immunodeficiency virus type 2 isolates from the Gambia. J Virol 1990;64:5177-5182.
    • (1990) J Virol , vol.64 , pp. 5177-5182
    • Schulz, T.F.1    Whitby, D.2    Hoad, J.G.3    Corrah, T.4    Whittle, H.5    Weiss, R.A.6
  • 40
    • 0026318387 scopus 로고
    • Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
    • Richman D, Shih C-K, Lowy I, Rose J, Prodanovich P, Goff S, and Griffin J: Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci USA 1991;88:11241-11245.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11241-11245
    • Richman, D.1    Shih, C.-K.2    Lowy, I.3    Rose, J.4    Prodanovich, P.5    Goff, S.6    Griffin, J.7
  • 41
    • 0027472841 scopus 로고
    • A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl) imida zo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thione (TTBO R82150)
    • Mellors JW, Im G-J, Tramontane E, Winkler SR, Medina DJ, Dutschman GE, Bazmi HZ, Piras G, Gonzalez CJ, and Cheng Y-C: A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl) imida zo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thione (TTBO R82150). Mol Pharmacol 1993;43:11-16.
    • (1993) Mol Pharmacol , vol.43 , pp. 11-16
    • Mellors, J.W.1    Im, G.-J.2    Tramontane, E.3    Winkler, S.R.4    Medina, D.J.5    Dutschman, G.E.6    Bazmi, H.Z.7    Piras, G.8    Gonzalez, C.J.9    Cheng, Y.-C.10
  • 44
    • 0342524024 scopus 로고
    • Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants
    • Hizi A, McGill C, and Hughes SH: Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants. Proc Natl Acad Sci USA 1988;85:1218-1222.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1218-1222
    • Hizi, A.1    McGill, C.2    Hughes, S.H.3
  • 45
    • 0027412181 scopus 로고
    • Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase
    • Boyer PL, Currens MJ, McMahon JB, Boyd MR, and Hughes SH: Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. J Virol 1993;67:2412-2420.
    • (1993) J Virol , vol.67 , pp. 2412-2420
    • Boyer, P.L.1    Currens, M.J.2    McMahon, J.B.3    Boyd, M.R.4    Hughes, S.H.5
  • 48
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 51
    • 0026542755 scopus 로고
    • In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine
    • Gao Q, Gu Z, Parniak MA, Li X, and Wainberg MA: In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine. J Virol 1992;66:12-19.
    • (1992) J Virol , vol.66 , pp. 12-19
    • Gao, Q.1    Gu, Z.2    Parniak, M.A.3    Li, X.4    Wainberg, M.A.5
  • 53
    • 0000701207 scopus 로고
    • Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro
    • Baba M, Pauwels R, Balzarini J, Arnout J, and Desmyter J: Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci USA 1988;85:6132-3136.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6132-13136
    • Baba, M.1    Pauwels, R.2    Balzarini, J.3    Arnout, J.4    Desmyter, J.5
  • 54
    • 0028120730 scopus 로고
    • HIV resistance to reverse transcriptase inhibitors
    • De Clercq E: HIV resistance to reverse transcriptase inhibitors. Biochem Pharmacol 1994;47:155-169.
    • (1994) Biochem Pharmacol , vol.47 , pp. 155-169
    • De Clercq, E.1
  • 55
    • 0026052102 scopus 로고
    • Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptase display reversed sensitivity to nonnucleoside analog inhibitors
    • Shih C-K, Rose JM, Hansen GL, Wu JC, Bacolla A, and Griffin JA: Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptase display reversed sensitivity to nonnucleoside analog inhibitors. Proc Natl Acad Sci USA 1991;88:9878-9882.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9878-9882
    • Shih, C.-K.1    Rose, J.M.2    Hansen, G.L.3    Wu, J.C.4    Bacolla, A.5    Griffin, J.A.6
  • 56
    • 0026721522 scopus 로고
    • Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis
    • De Vreese K, Debyser Z, Vandamme A-M, Pauwels R, Desmyter J, De Clercq E, and Anné J: Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. Virology 1992;188:900-904.
    • (1992) Virology , vol.188 , pp. 900-904
    • De Vreese, K.1    Debyser, Z.2    Vandamme, A.-M.3    Pauwels, R.4    Desmyter, J.5    De Clercq, E.6    Anné, J.7
  • 57
    • 0027381149 scopus 로고
    • Human immunodeficiency virus type 1 drug resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives
    • Balzarini J, Karlsson A, and De Clercq E: Human immunodeficiency virus type 1 drug resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. Mol Pharmacol 1993;44:694-701.
    • (1993) Mol Pharmacol , vol.44 , pp. 694-701
    • Balzarini, J.1    Karlsson, A.2    De Clercq, E.3
  • 58
    • 0027214433 scopus 로고
    • Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy
    • Balzarini J, Karlsson A, Pérez-Pérez M-J, Camarasa M-J, Tarpley WG, and De Clercq E: Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy. J Virol 1993;67:5353-5359.
    • (1993) J Virol , vol.67 , pp. 5353-5359
    • Balzarini, J.1    Karlsson, A.2    Pérez-Pérez, M.-J.3    Camarasa, M.-J.4    Tarpley, W.G.5    De Clercq, E.6
  • 60
    • 0025775810 scopus 로고
    • HIV reverse transcriptase structure-function relationships
    • Jacobo-Molina A and Arnold E: HIV reverse transcriptase structure-function relationships. Biochemistry 1991;30:6351-6361.
    • (1991) Biochemistry , vol.30 , pp. 6351-6361
    • Jacobo-Molina, A.1    Arnold, E.2
  • 61
    • 0028172345 scopus 로고
    • Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: Implications for mechanisms of drug inhibition and resistance
    • Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, Pauwels R, Andries K, Janssen PAJ, and Arnold E: Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: Implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994;243:369-387.
    • (1994) J Mol Biol , vol.243 , pp. 369-387
    • Tantillo, C.1    Ding, J.2    Jacobo-Molina, A.3    Nanni, R.G.4    Boyer, P.L.5    Hughes, S.H.6    Pauwels, R.7    Andries, K.8    Janssen, P.A.J.9    Arnold, E.10
  • 62
  • 64
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin JM: HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science 1995;267:483-489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1


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