A new twist in the feedback loop: Stress-activated MDM2 destabilization is required for p53 activation

Cell Cycle

Volumn 4, Issue 3, 2005, Pages 411-417

  Stommel, Jayne M ^a,b   Wahl, Geoffrey M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Auto ubiquitination; DNA damage; HDM2; MDM2; MDMX; p53; Protein stability; Ubiquitination

Indexed keywords

ARF PROTEIN; DNA; PROTEASOME; PROTEIN MDM2; PROTEIN P53; RNA; UBIQUITIN PROTEIN LIGASE E3;

CELL DAMAGE; CORRELATION ANALYSIS; DNA DAMAGE; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; INHIBITION KINETICS; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; REGULATORY MECHANISM; REVIEW; STIMULUS; STRESS; TRANSACTIVATION; TRANSCRIPTION INITIATION; WILD TYPE;

EID: 25444482673     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.3.1522     Document Type: Review

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