Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

Biochemical Journal

Volumn 342, Issue 1, 1999, Pages 133-141

  Craig, Ashley L ^a   Burch, Lindsay ^a   Vojtesek, Borek ^b   Mikutowska, Jaroslava ^b   Thompson, Alastair ^a   Hupp, Ted R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

Author keywords

Kinase; Monoclonal antibody; Signalling; Transcription

Indexed keywords

MONOCLONAL ANTIBODY; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN MDM2; PROTEIN P53; SERINE; SYNTHETIC PEPTIDE; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; INSECT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BREAST NEOPLASMS; CELL LINE; EPITOPES; HUMANS; ISOELECTRIC POINT; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SPODOPTERA; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; INSECTA;

EID: 0033567340     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3420133     Document Type: Article

References (50)

1. Oren, M. (1997) Cell 90, 829-832
2. Pietenpol, J. A., Tokino, T., Thiagalingam, S., el-Deiry, W. S., Kinzler, K. W. and Vogelstein, B. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1998-2002
3. Soussi, T. and May, P. (1996) J. Mol. Biol. 260, 623-637
4. Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E. and Anderson, C. W. (1992) Mol. Cell. Biol. 12, 5041-5049
5. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B. and Siliciano, J. D. (1998) Science 281, 1677-1679
6. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y. and Ziv, Y. (1998) Science 281, 1674-1677
7. Shieh, S. Y., Ikeda, M., Taya, Y. and Prives, C. (1997) Cell 91, 325-334
8. Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R. and Brady, J. N. (1998) J. Biol. Chem. 273, 33048-33053
9. Pise-Masison, C. A., Radonovich, M., Sakaguchi, K., Appella, E. and Brady, J. N. (1998) J. Virol. 72, 6348-6355
10. Bargonetti, J., Manfredi, J. J., Chen, X., Marshak, D. R. and Prives, C. (1993) Genes Dev. 7, 2565-2574
11. Kaghad, M., Bonnet, H., Yang, A., Creancier, L., Biscan, J. C., Valent, A., Minty, A., Chalon P., Leilas, J. M., Dumont, X. et al. (1997) Cell 90, 809-819
12. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D. and McKeon, F. (1998) Mol. Cell 2, 305-316
13. Cho, Y., Gorina, S., Jeffrey, P. D. and Pavletich, N. P. (1994) Science 265, 346-355
14. Hupp, T. R., Meek, D. W., Midgley, C. A. and Lane, D. P. (1993) Nucleic Acids Res. 21, 3167-3174
15. Davison, T. S., Yin, P., Nie, E., Kay, C. and Arrowsmith, C. H. (1998) Oncogene 17, 651-656
16. Lomax, M. E., Barnes, D. M., Hupp, T. R., Picksley, S. M. and Campleiohn, R. S. (1998) Oncogene 17, 643-649
17. Johnson, C. R., Worin, P. E., Arrowsmith, C. H. and Freire, E. (1995) Biochemistry 34, 5309-5016
18. Jeffrey, P. D., Gorina, S. and Pavletich, N. P. (1995) Science 267, 1498-1502
19. Hupp, T. R., Sparks, A. and Lane, D. P. (1995) Cell 83, 237-245
20. Anderson, M. E,. Woelker, B., Reed, M., Wang, P. and Tegtmeyer, P. (1997) Mol. Cell. Biol. 17, 6255-6264
21. Selivanova, G., Iotsova, V., Okan, I., Pritsche, M., Strom, M., Groner, B., Grafstrom, R. C. and Wiman, K. G. (1997) Nat. Med. (N.Y.) 3, 632-638
22. Blaydes, J. P. and Hupp, T. R. (1998) Oncogene 17, 1045-1052
23. Hupp, T. R. and Lane, D. P. (1994) Curr. Biol. 4, 865-875
24. Hupp, T. R. and Lane, D. P. (1995) J. Biol. Chem. 270, 18165-18174
25. Mundt, M., Hupp, T., Pritsche, M., Merkle, C. Hansen, S. Lane, O. and Groner, B. (1997) Oncogene 15, 237-244
26. Takenaka, I., Morin, F., Seizinger, B. R. and Kley, N. (1995) J. Biol. Chem. 270, 5405-5411
27. Waterman, M. J., Stavridi, E. S., Waterman, J. L. and Halazonetis, T. D. (1998) Nat. Genet. 19, 175-178
28. Vojtesek, B., Dolezalova, H., Lauerova, L., Svitakova, M., Havlis, P., Kovarik, J., Midgley, C. A. and Lane, D. P. (1995) Oncogene 10, 389-393
29. Stephen, C. W., Helminen, P. and Lane, D. P. (1995) J. Mol. Biol. 248, 58-78
30. Thompson, A. M., Steel, C. M., Chetty, U., Dixon, J. M. and Carter, D. C. (1998) Br. J. Surg. 82, 210-211
31. Hopwood, D., Moitra, S., Vojtesek, B., Johnston, D. A., Dillon, J. F. and Hupp, T. R. (1997) Gut 41, 156-163
32. Loffler, B. M. and Kunze, H. (1989) Anal. Biochem. 177, 100-102
33. Hubbard, M. J. and Cohen, P. (1993) Trends Biochem. Sci. 18, 172-177
34. Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J. and Pavletich, N. P. (1996) Science 274, 948-953
35. Bottger, A., Bottger, V., Garcia-Echeverna, C., Chene, P., Hochkeppel, H. K., Sampson, W., Ang, K., Howard, S. F., Picksley, S. M. and Lane, D. P. (1997) J. Mol. Biol. 269, 744-756
36. Bond, J., Webley, K., Wyllie, F., Jones, C., Craig, A., Hupp, T. and Wynford-Thomas, D. (1999) Oncogene, in the press
37. Scharer, E. and Iggo, R. (1992) Nucleic Acids Res 20, 1539-1545
38. Thiagalingam, S., Kinzler, K. W. and Vogelstein, B. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 6062-6066
39. Casso, D. and Beach, D. (1996) Mol. Gen. Genet. 252, 518-529
40. Pearson, G. D. and Merrill, G. F. (1998) J. Biol. Chem. 273, 5431-5434
41. Selkirk, J. K., He, C., Patterson, R. M. and Merrick, B. A. (1996) Electrophoresis 17, 1764-1771
42. Patterson, R. M., He, C., Selkirk, J. K. and Merrick, B. A. (1996) Arch. Biochem. Biophys. 330, 71-79
43. Fredersdorf, S., Burns, J., Milne, A. M., Packham, G., Fallis, L., Gillett, C. E., Royds, J. A., Peston, D., Hall, P. A., Hanby, A. M. et al. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 6380-6385
44. Lin, J., Chen, J., Elenbass, B. and Levine, A. J. (1994) Genes Dev. 8, 1235-1246
45. Chesnokov, I., Chu, W. M., Botchan, M. R. and Schmid, C. W. (1996) Mol. Cell. Biol. 16, 7084-7088
46. Cairns, C. A. and White, R. J. (1998) EMBO J. 17, 3112-3123
47. Harvey, M., Sands, A. T., Weiss, R. S., Hegi, M. E., Wiseman, R. W., Pantazis, P., Giovanella, B. C., Tainsky, M. A., Bradley, A. and Donehower, L. A. (1993) Oncogene 8, 2457-2467
48. He, C., Merrick, B. A., Patterson, R. M. and Selkirk, J. K. (1995) Appl. Theor. Electrophor. 5, 15-24
49. Lane, D. P. (1998) Lancet 351 (Suppl. 2), SII17-SII20
50. Bischoff, J. R., Casso, D. and Beach, D. (1992) Mol. Cell. Biol. 12, 1405-1411