-
1
-
-
0035868386
-
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
-
Argentini, M., N. Barboule, and B. Wasylyk. 2001. The contribution of the acidic domain of MDM2 to p53 and MDM2 stability. Oncogene 20:1267-1275.
-
(2001)
Oncogene
, vol.20
, pp. 1267-1275
-
-
Argentini, M.1
Barboule, N.2
Wasylyk, B.3
-
2
-
-
0033552613
-
Regulation of p53 stability
-
Ashcroft, M., and K. H. Vousden. 1999. Regulation of p53 stability. Oncogene 18:7637-7643.
-
(1999)
Oncogene
, vol.18
, pp. 7637-7643
-
-
Ashcroft, M.1
Vousden, K.H.2
-
3
-
-
0036340096
-
Hypophosphorylation of Mdm2 augments p53 stability
-
Blattner, C., T. Hay, D. W. Meek, and D. P. Lane. 2002. Hypophosphorylation of Mdm2 augments p53 stability. Mol. Cell. Biol. 22:6170-6182.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6170-6182
-
-
Blattner, C.1
Hay, T.2
Meek, D.W.3
Lane, D.P.4
-
4
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd, S. D., K. Y. Tsai, and T. Jacks. 2000. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell Biol. 2:563-568.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
5
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang, S., J. P. Jensen, R. L. Ludwig, K. H. Vousden, and A. M. Weissman. 2000. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 275:8945-8951.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
6
-
-
0036606416
-
mdmx is a negative regulator of p53 activity in vivo
-
Finch, R. A., D. B. Donoviel, D. Potter, M. Shi, A. Fan, D. D. Freed, C. Y. Wang, B. P. Zambrowicz, R. Ramirez-Solis, A. T. Sands, and N. Zhang. 2002. mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 62:3221-3225.
-
(2002)
Cancer Res.
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
Wang, C.Y.7
Zambrowicz, B.P.8
Ramirez-Solis, R.9
Sands, A.T.10
Zhang, N.11
-
7
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
Geyer, R. K., Z. K. Yu, and C. G. Maki. 2000. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat. Cell Biol. 2:569-573.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
8
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
Gu, J., H. Kawai, L. Nie, H. Kitao, D. Wiederschain, A. G. Jochemsen, J. Parant, G. Lozano, and Z. M. Yuan. 2002. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J. Biol. Chem. 277:19251-19254.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
Parant, J.7
Lozano, G.8
Yuan, Z.M.9
-
9
-
-
0035196861
-
Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
-
Gu, J., L. Nie, D. Wiederschain, and Z. M. Yuan. 2001. Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol. Cell. Biol. 21:8533-8546.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8533-8546
-
-
Gu, J.1
Nie, L.2
Wiederschain, D.3
Yuan, Z.M.4
-
10
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
11
-
-
0034624678
-
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
-
Honda, R., and H. Yasuda. 2000. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 19:1473-1476.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
12
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat, M. H., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
13
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
15
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini, D., E. L. Denchi, D. Danovi, A. Jochemsen, M. Capillo, A. Gobbi, K. Helin, P. G. Pelicci, and J. C. Marine. 2002. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol. 22:5527-5538.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Denchi, E.L.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
Helin, K.7
Pelicci, P.G.8
Marine, J.C.9
-
16
-
-
0033579412
-
Regulation of the p53 tumor suppressor protein
-
Oren, M. 1999. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 274:36031-36034.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36031-36034
-
-
Oren, M.1
-
17
-
-
0032988122
-
Introduction: p53 - The first twenty years
-
Oren, M., and V. Rotter. 1999. Introduction: p53 - the first twenty years. Cell. Mol. Life Sci. 55:9-11.
-
(1999)
Cell. Mol. Life Sci.
, vol.55
, pp. 9-11
-
-
Oren, M.1
Rotter, V.2
-
18
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant, J., A. Chavez-Reyes, N. A. Little, W. Yan, V. Reinke, A. G. Jochemsen, and G. Lozano. 2001. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat. Genet. 29:92-95.
-
(2001)
Nat. Genet.
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
19
-
-
0035266128
-
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53
-
Ramos, Y. F., R. Stad, J. Attema, L. T. Peltenburg, A. J. van der Eb, and A. G. Jochemsen. 2001. Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. Cancer Res. 61:1839-1842.
-
(2001)
Cancer Res.
, vol.61
, pp. 1839-1842
-
-
Ramos, Y.F.1
Stad, R.2
Attema, J.3
Peltenburg, L.T.4
Van der Eb, A.J.5
Jochemsen, A.G.6
-
20
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
Sharp, D. A., S. A. Kratowicz, M. J. Sank, and D. L. George. 1999. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J. Biol. Chem. 274:38189-38196.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
21
-
-
0037047345
-
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
-
Shimizu, H., L. R. Burch, A. J. Smith, D. Dornan, M. Wallace, K. L. Ball, and T. R. Hupp. 2002. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J. Biol. Chem. 277:28446-28458.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28446-28458
-
-
Shimizu, H.1
Burch, L.R.2
Smith, A.J.3
Dornan, D.4
Wallace, M.5
Ball, K.L.6
Hupp, T.R.7
-
22
-
-
0035203715
-
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
-
Stad, R., N. A. Little, D. P. Xirodimas, R. Frenk, A. J. van der Eb, D. P. Lane, M. K. Saville, and A. G. Jochemsen. 2001. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep. 2:1029-1034.
-
(2001)
EMBO Rep.
, vol.2
, pp. 1029-1034
-
-
Stad, R.1
Little, N.A.2
Xirodimas, D.P.3
Frenk, R.4
Van der Eb, A.J.5
Lane, D.P.6
Saville, M.K.7
Jochemsen, A.G.8
-
23
-
-
0033051322
-
MDM2 interacts with MDMX through their RING finger domains
-
Tanimura, S., S. Ohtsuka, K. Mitsui, K. Shirouzu, A. Yoshimura, and M. Ohtsubo. 1999. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett. 447:5-9.
-
(1999)
FEBS Lett.
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
Ohtsuka, S.2
Mitsui, K.3
Shirouzu, K.4
Yoshimura, A.5
Ohtsubo, M.6
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