Development of a binding assay for p53/HDM2 by using homogeneous time- resolved fluorescence

Analytical Biochemistry

Volumn 278, Issue 1, 2000, Pages 29-38

  Kane, Stefanie A ^a   Fleener, Catherine A ^a   Zhang, Yun S ^a   Davis, Lenora J ^a   Musselman, Amy L ^a   Huang, Pearl S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HDM2; HTRF; P53; Protein protein interaction

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CELL DEATH; CELL SIGNALING; CHEMICAL DETECTION; ENERGY TRANSFER; FLUORESCENCE; PROTEINS;

FLUORESCENCE RESONANCE ENERGY TRANSFER; HDM2; HOMOGENEOUS TIME-RESOLVED FLUORESCENCE ASSAYS; HTRF; PROTEIN-PROTEIN INTERACTIONS; SERINE PHOSPHORYLATION; TIME-RESOLVED FLUORESCENCE; TUMOR SUPPRESSOR PROTEINS;

FLUOROPHORES;

EUROPIUM; ONCOPROTEIN; PROTEIN HDM 2; PROTEIN P53; REAGENT; STREPTAVIDIN; STREPTAVIDIN XL665; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CONJUGATION; ENERGY TRANSFER; FLUORESCENCE; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ASSAY; REACTION TIME;

EID: 0034142388     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1999.4413     Document Type: Article

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