Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

EMBO Reports

Volumn 2, Issue 11, 2001, Pages 1029-1034

  Stad, Robert ^a   Little, Natalie A ^a   Xirodimas, Dimitris P ^b   Frenk, Ruth ^a   Van Der Eb, Alex J ^a   Lane, David P ^b   Saville, Mark K ^b   Jochemsen, Aart G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; SEQUENCE HOMOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL NUCLEUS; CYTOPLASM; DIMERIZATION; HUMANS; LIGASES; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MUTATION; NUCLEAR PROTEINS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0035203715     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve227     Document Type: Article

References (16)

1. The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
2. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
3. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
4. The MDM2 RING-finger domain is required to promote p53 nuclear export
5. Mdm2 promotes the rapid degradation of p53
6. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
7. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
8. MdmX protects p53 from Mdm2-mediated degradation
9. Regulation of p53 stability by Mdm2
10. ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
11. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
12. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
13. MDMX: A novel p53-binding protein with some functional properties of MDM2
14. Hdmx stabilizes Mdm2 and p53
15. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
16. Different effects of p14ARF on the levels of ubiquitylated p53 and Mdm2 in vivo