메뉴 건너뛰기




Volumn 10, Issue 2, 1999, Pages 87-92

Analysis of the degradation function of Mdm2

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 0032963156     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (97)

References (38)
  • 1
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 3
    • 0031802921 scopus 로고    scopus 로고
    • Keeping an old friend under control: Regulation of p53 stability
    • Kubbutat, M. H. G., and Vousden, K. H. Keeping an old friend under control: regulation of p53 stability. Mol. Med. Today, 4: 250-256, 1998.
    • (1998) Mol. Med. Today , vol.4 , pp. 250-256
    • Kubbutat, M.H.G.1    Vousden, K.H.2
  • 5
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. Mdm2 promotes the rapid degradation of p53. Nature (Lond.), 387: 296-299, 1997.
    • (1997) Nature (Lond.) , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 6
    • 0031282325 scopus 로고    scopus 로고
    • Design of a synthetic Mdm-2 binding mini-protein that activates the p53 response in vivo
    • Böttger, A., Böttger, V., Sparks, A., Liu, W-L., Howard, S. F., and Lane, D. P. Design of a synthetic Mdm-2 binding mini-protein that activates the p53 response in vivo. Curr. Biol., 7: 860-869, 1997.
    • (1997) Curr. Biol. , vol.7 , pp. 860-869
    • Böttger, A.1    Böttger, V.2    Sparks, A.3    Liu, W.-L.4    Howard, S.F.5    Lane, D.P.6
  • 7
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., Tanaka, H., and Yasuda, H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett., 420: 25-27, 1997.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 8
    • 0032518917 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
    • Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., and Levine, A. J. Nucleocytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J., 17: 554-564, 1998.
    • (1998) EMBO J. , vol.17 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 9
    • 0027459198 scopus 로고
    • mdm-2 expression is induced by wild type p53 activity
    • Barak, Y., Juven, T., Haffner, R., and Oren, M. mdm-2 expression is induced by wild type p53 activity. EMBO J., 12: 461-468, 1993.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 10
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., Zambetti, G. P., George, D. L., and Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    George, D.L.3    Levine, A.J.4
  • 12
    • 0027244853 scopus 로고
    • The p53 mdm-2 autoregulatory feedback loop
    • Wu, X. W., Bayle, J. H., Olson, D., and Levine, A. J. The p53 mdm-2 autoregulatory feedback loop. Genes Dev., 7: 1126-1132, 1993.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.W.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 13
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (Lond.), 378: 203-206, 1995.
    • (1995) Nature (Lond.) , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 14
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S. N., Roe, A. E., Donehower, L. A., and Bradley, A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (Lond.), 378: 206-208, 1995.
    • (1995) Nature (Lond.) , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 16
    • 0032080297 scopus 로고    scopus 로고
    • The human oncoprotein MDM2 arrests the cell cycle: Elimination of its cell-cycle-inhibitory function induces tumorigenesis
    • Brown, L. R., Thomas, C. A., and Deb, S. P. The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis. EMBO J., 17: 2513-2525, 1998.
    • (1998) EMBO J. , vol.17 , pp. 2513-2525
    • Brown, L.R.1    Thomas, C.A.2    Deb, S.P.3
  • 17
    • 0029824669 scopus 로고    scopus 로고
    • Alternatively spliced mdm2 transcripts with bss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
    • Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E., and Lunec, J. Alternatively spliced mdm2 transcripts with bss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat. Med., 2: 912-917, 1996.
    • (1996) Nat. Med. , vol.2 , pp. 912-917
    • Sigalas, I.1    Calvert, A.H.2    Anderson, J.J.3    Neal, D.E.4    Lunec, J.5
  • 18
    • 1842378642 scopus 로고    scopus 로고
    • The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
    • Leveillard, T., and Wasylyk, B. The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter. J. Biol. Chem., 272: 30651-30661, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30651-30661
    • Leveillard, T.1    Wasylyk, B.2
  • 19
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut, C. J., Goodrich, J. A., and Tjian, R. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev., 11: 1974-1986, 1997.
    • (1997) Genes Dev. , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 22
    • 0031702817 scopus 로고    scopus 로고
    • Regulation of Mdm2 directed degradation by the C-terminus of p53
    • Kubbutat, M. H. G., Ludwig, R. L., Ashcroft, M., and Vousden, K. H. Regulation of Mdm2 directed degradation by the C-terminus of p53. Mol. Cell. Biol., 18: 5690-5698, 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5690-5698
    • Kubbutat, M.H.G.1    Ludwig, R.L.2    Ashcroft, M.3    Vousden, K.H.4
  • 23
    • 0029171789 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
    • Chen, J., Lin, J., and Levine, A. J. Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med., 1: 142-152, 1995.
    • (1995) Mol. Med. , vol.1 , pp. 142-152
    • Chen, J.1    Lin, J.2    Levine, A.J.3
  • 24
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3    Vogelstein, B.4    R, W.5
  • 25
    • 0027500246 scopus 로고
    • Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
    • Frische, M., Haessler, C., and Brandner, G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene, 8: 307-318, 1993.
    • (1993) Oncogene , vol.8 , pp. 307-318
    • Frische, M.1    Haessler, C.2    Brandner, G.3
  • 27
    • 0032525905 scopus 로고    scopus 로고
    • The ubiqutin-protein ligase E6-associated protein (E6-AP) serves as its own substrate
    • Nuber, U., Schwarz, S. E., and Scheffner, M. The ubiqutin-protein ligase E6-associated protein (E6-AP) serves as its own substrate. Eur. J. Biochem., 254: 643-649, 1998.
    • (1998) Eur. J. Biochem. , vol.254 , pp. 643-649
    • Nuber, U.1    Schwarz, S.E.2    Scheffner, M.3
  • 28
    • 0029760621 scopus 로고    scopus 로고
    • The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
    • Elenbaas, B., Dobbelstein, M., Roth, J., Shenk, T., and Levine, A. J. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med., 2: 439-451, 1996.
    • (1996) Mol. Med. , vol.2 , pp. 439-451
    • Elenbaas, B.1    Dobbelstein, M.2    Roth, J.3    Shenk, T.4    Levine, A.J.5
  • 31
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell, 92: 725-734, 1998.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 32
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell, 75: 495-505, 1993.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 33
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Barak, Y., and Oren, M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J., 75: 1596-1606, 1996.
    • (1996) EMBO J. , vol.75 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 34
    • 0027980357 scopus 로고
    • Interaction of p53 with MDM2 is independent of E6 and does not mediate wild-type transformation suppressor function
    • Marston, N. J., Crook, T., and Vousden, K. H. Interaction of p53 with MDM2 is independent of E6 and does not mediate wild-type transformation suppressor function. Oncogene, 9: 2707-2716, 1994.
    • (1994) Oncogene , vol.9 , pp. 2707-2716
    • Marston, N.J.1    Crook, T.2    Vousden, K.H.3
  • 35
    • 0028338653 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein
    • Helin, K., and Harlow, E. Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J. Virol., 68: 5027-5035, 1994.
    • (1994) J. Virol. , vol.68 , pp. 5027-5035
    • Helin, K.1    Harlow, E.2
  • 36
    • 0027426917 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation
    • Helin, K., Wu, C., Fottaey, A., Lees, J., Dynlacht, B., Ngwu, C., and Harlow, E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes Dev., 7: 1850-1861, 1993.
    • (1993) Genes Dev. , vol.7 , pp. 1850-1861
    • Helin, K.1    Wu, C.2    Fottaey, A.3    Lees, J.4    Dynlacht, B.5    Ngwu, C.6    Harlow, E.7
  • 37
    • 0026648086 scopus 로고
    • Identification of a growth suppression domain within the retinoblastoma gene product
    • Qin, X.-Q., Chittenden, T., Livingston, D. M., and Kaelin, W. G., Jr. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev., 6: 953-964, 1992.
    • (1992) Genes Dev. , vol.6 , pp. 953-964
    • Qin, X.-Q.1    Chittenden, T.2    Livingston, D.M.3    Kaelin W.G., Jr.4
  • 38
    • 0029031942 scopus 로고
    • Oligomerisation of full-length p53 contributes to the interaction with mdm2 but not HPV E6
    • Marston, N. J., Jenkins, J. R., and Vousden, K. H. Oligomerisation of full-length p53 contributes to the interaction with mdm2 but not HPV E6. Oncogene, 10: 1709-1715, 1995.
    • (1995) Oncogene , vol.10 , pp. 1709-1715
    • Marston, N.J.1    Jenkins, J.R.2    Vousden, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.