MDMX: A novel p53-binding protein with some functional properties of MDM2

EMBO Journal

Volumn 15, Issue 19, 1996, Pages 5349-5357

  Shvarts, Avi ^a   Steegenga, Wilma T ^a   Riteco, Nicole ^a   Van Laar, Theo ^a   Dekker, Patrick ^a   Bazuine, Merlijn ^a   Van Ham, Reinier C A ^a   Van Der Houven Van Oordt, Willemien ^a   Hateboer, Guus ^b   Van Der Eb, Alex J ^a   Jochemsen, Aart G ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

MDM2; MDMX; P53; Transcription regulation; UV irradiation

Indexed keywords

CELL PROTEIN; MESSENGER RNA; PROTEIN P53;

ARTICLE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET IRRADIATION;

EID: 10144259344     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00919.x     Document Type: Article

References (64)

1. Agoff, S.N., Hou, J., Linzer, D.I.H. and Wu, B. (1993) Regulation of the human hsp70 promoter by p53. Science, 259, 84-87.
2. Ayer, D.E., Kretzner, L. and Eisenman, R.N. (1993) Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell, 72, 211-222.
3. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K. and Vogelstein, B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912-915.
4. Barak, Y. and Oren, M. (1992) Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J., 11, 2115-2121.
5. Barak, Y., Juven, T., Haffner, R. and Oren, M. (1993) Mdm2 expression is induced by wild-type p53 activity. EMBO J., 12, 461-468.
6. Barak, Y., Gottlieb, E., Juven-Gershon, T. and Oren, M. (1994) Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev., 8, 1739-1749.
7. Boddy, M.N., Freemont, P.S. and Borden, K.L.B. (1994) The p53-associated protein MDM2 contains a newly characterized zinc binding domain called the RING finger. Trends Biochem. Sci., 19, 198-199.
8. Brown, D.R., Deb, S., Munoz, R.M., Subler, M.A. and Deb, S.P. (1993) The tumor suppressor p53 and the oncoprotein simian virus-40 T-antigen bind to overlapping domains on the mdm2 protein. Mol. Cell. Biol., 13, 6849-6857.
9. Bueso-Ramos, C.E., Yang, Y., deLeon, E., McCown, P., Stass, S.A. and Albitar, M. (1993) The human MDM-2 oncogene is overexpressed in leukemias. Blood., 82, 2617-2623.
10. Cawthon, R.M. et al. (1990) A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell, 62, 193-201.
11. Chen, J.D., Lin, J.Y. and Levine, A.J. (1995) Regulation of transcription functions of the p53 tumor suppressor by the mdm-2. Mol. Med., 1, 142-152.
12. Corvi, R., Savelyeva, L., Amler, L., Handgretinger, R. and Schwab, M. (1995) Cytogenetic evolution of MYCN and MDM2 amplification in the neuroblastoma LS tumour and its cell line. Eur. J. Cancer, 31A, 520-523.
13. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Butel, J.S. and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature, 356, 215-221.
14. Fakharzadeh, S.S., Trusko, S.P. and George, D.L. (1991) Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J., 10, 1565-1569.
15. Feitelson, M.A., Zhu, M., Duan, L.X. and London, W.T. (1993) Hepatitis B X-antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene, 8, 1109-1117.
16. Fields, S. and Jang, S.K. (1990) Presence of a potent transcription activating sequence in the p53 protein. Science, 249, 1046-1049.
17. Habuchi, T., Kinoshita, H., Yamada, H., Kakehi, Y., Ogawa, O., Wu, W.J., Takahashi, R., Sugiyama, T. and Yoshida, O. (1994) Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. J. Natl Cancer Inst., 86, 1331-1335.
18. Haines, D.S., Landers, J.E., Engle, L.J. and George, D.L. (1994) Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol. Cell. Biol., 14, 1171-1178.
19. Hateboer, G., Gennissen, A., Ramos, Y.F.M., Kerkhoven, R.M., Sonntagbuck, V., Stunnenberg, H.G. and Bernards, R. (1995) BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. EMBO J., 14, 3159-3169.
20. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C.C. (1991) p53 mutations in human cancers. Science, 253, 49-53.
21. Hollstein, M. et al. (1994) Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res., 22, 3551-3555.
22. Jones, S.N., Roe, A.E., Donehower, L.A. and Bradley, A. (1995) Rescue of embryonic lethality in mdm2-deficient mice by absence of p53. Nature, 378, 206-208.
23. Juven, T., Barak, Y., Zauberman, A., George, D.L. and Oren, M. (1993) Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene, 8, 3411-3416.
24. Landers, J.E., Haines, D.S., Strauss, J.F. and George, D.L. (1994) Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene, 9, 2745-2750.
25. Lane, D.P. (1992) Cancer - p53, guardian of the genome. Nature, 358, 15-16.
26. Lane, D.P. and Crawford, L.V. (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature, 278, 261-263.
27. Lee, E.Y.H.P., Chang, C.Y., Hu, N.P., Wang, Y.C.J., Lai, C.C., Herrup, K., Lee, W.H. and Bradley, A., (1992) Mice deficient for rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature, 359, 288-294.
28. Lianes, P., Orlow, L., Zhang, Z.F., Oliva, M.R., Sarkis, A.S., Reuter, V.E. and Cordoncardo, C. (1994) Altered patterns of MDM2 and TP53 expression in human bladder cancer. J. Natl Cancer Inst., 86, 1325-1330.
29. Linzer, D.I. and Levine, A.J. (1979) Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell, 17, 43-52.
30. Lu, H. and Levine, A.J. (1995) Human TAF(II)31 protein is a transcriptional coactivator of the p53 protein. Proc. Natl Acad. Sci. USA, 92, 5154-5158.
31. Maestro, R., Gloghini, A., Doglioni, C., Gasparotto, D., Vukosavljevic, T., Dere, V., Laurino, L., Carbone, A. and Boiocchi, M. (1995) MDM2 overexpression does not account for stabilization of wild-type p53 protein in non-Hodgkin's lymphomas. Blood., 85, 3239-3246.
32. Maheswaran, S., Park, S., Bernard, A., Morris, J.F., Rauscher, F.J., Hill, D.E. and Haber, D.A. (1993) Physical and functional interaction between WT1 and p53 proteins. Proc. Natl Acad. Sci. USA, 90, 5100-5104.
33. Malkin, D. et al. (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science, 250, 1233-1238.
34. Maniatis, T., Fritsch, E.F. and Sambrook, J. (1982) Molecular Cloning, a Laboratory Manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
35. Martin, D.W., Munoz, R.M., Subler, M.A. and Deb, S. (1993) p53 binds to the TATA-binding protein-TATA complex. J. Biol. Chem., 268, 13062-13067.
36. Martin, K., Trouche, D., Hagemeier, C., Sorensen, T.S., La Thangue, N.B. and Kouzarides, T. (1995) Stimulation of E2FI/DP1 transcriptional activity by MDM2 oncoprotein. Nature, 375, 691-694.
37. Menke, A.L., van Ham, R.C.A., Sonneveld, E., Shvarts, A., Stanbridge, E.J., Miyagawa, K., van der Eb, A.J. and Jochemsen, A.G. (1995) Human chromosome 11 suppresses the tumorigenicity of adenovirus transformed baby rat kidney cells: involvement of the Wilms' tumor 1 gene. Int. J. Cancer, 63, 76-85.
38. Moll, U.M., Riou, G. and Levine, A.J. (1992) Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. Natl Acad. Sci. USA, 89, 7262-7266.
39. Moll, U.M., Laquaglia, M., Benard, J. and Riou, G. (1995) Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc. Natl Acad. Sci. USA, 92, 4407-4411.
40. Momand, J., Zambetti, G.P., Olson, D.C., George, D. and Levine, A.J. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69, 1237-1245.
41. Montes de Oca Luna, R., Wagner, D.S. and Lozano, G. (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature, 378, 203-206.
42. O'Connor, D.J., Lam, E.W.F., Griffin, S., Zhong, S., Leighton, L.C., Burbidge, S.A. and Lu, X. (1995) Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DPI. EMBO J., 14, 6184-6192.
43. Oliner, J.D., Kinzler, K.W., Meltzer, P.S., George, D.L. and Vogelstein, B. (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature, 358, 80-83.
44. Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gvuris, J., Kinzler, K.W. and Vogelstein, B. (1993) Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature, 362, 857-860.
45. Perry, M.E., Piette, J., Zawadzki, J.A., Harvey, D. and Levine, A.J. (1993) The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc. Natl Acad. Sci. USA, 90, 11623-11627.
46. Picksley, S.M. and Lane, D.P. (1993) The p53-mdm2 autoregulatory feedback loop - a paradigm for the regulation of growth control by p53? Bioessays, 15, 689-690.
47. Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E.E. and Collins, V.P. (1993) Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res., 53, 2736-2739.
48. Saraste, M., Sibbald, P.R. and Wittinghofer, A. (1990) The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci., 15, 430-434.
49. Samow, P., Ho, Y.S., Williams, J. and Levine, A.J. (1982) Adenovirus E1B-58 kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell, 28, 387-394.
50. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. and Howley, P.M. (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell, 63, 1129-1136.
51. Seto, E., Usheva, A., Zambetti, G.P., Momand, J., Horikoshi, N., Weinmann, R., Levine, A.J. and Shenk, T. (1992) Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc. Natl Acad. Sci. USA, 89, 12028-12032.
52. Srivastava, S., Tong, Y.A., Devadas, K., Zou, Z.Q., Chen, Y., Pirallo, K.F. and Chang, E.H. (1992) The status of the p53 gene in human papilloma virus positive or negative cervical carcinoma cell lines. Carcinogenesis, 13, 1273-1275
53. Steegenga, W.T., Van Laar, T., Shvarts, A., Terleth, C., Van der Eb, A.J. and Jochemsen, A.G. (1995a) Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins. Virology, 212, 543-554.
54. Steegenga, W.T., Shvarts, A., Van Laar, T., Van der Eb, A.J. and Jochemsen, A.G. (1995b) Altered phosphorylation and oligomerization of p53 in adenovirus type 12-transformed cells. Oncogene, 11, 49-57.
55. Thut, C.J., Chen, J.L., Klemm, R. and Tjian, R. (1995) p53 transcriptional activation mediated by coactivators TAF(II)40 and TAF(II)60. Science, 267, 100-104.
56. Ueda, H., Ullrich, S.J., Gangemi, J.D., Kappel, C.A., Ngo, L., Feitelson, M.A. and Jay, G. (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nature Genet., 9, 41-47.
57. Van der Eb, A.J. and Graham, F.L. (1980) Assay of transforming activity of tumor virus DNA. Methods Enzymol., 142, 65-73.
58. Van Laar, T., Steegenga, W.T., Jochemsen, A.G., Terleth, C. and Van der Eb, A.J. (1995) GM1492 human diploid skin fibroblasts lack the p53-dependent G1 cell-cycle checkpoint. Biochem. Biophys. Res. Commun., 217, 769-776.
59. Werness, B.A., Levine, A.J. and Howley, P.M. (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science, 248, 76-79.
60. Wu, X.W., Bayle, J.H., Olson, D. and Levine, A.J. (1993) The p53 mdm-2 autoregulatory feedback loop. Genes Dev., 7, 1126-1132.
61. Xiao, Z.X., Chen, J.D., Levine, A.J., Modjtahedi, N., Xing, J., Sellers, W.R. and Livingston, D.M. (1995) Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375, 694-698.
62. Zantema, A., Schrier, P.I., Davis-Olivier, A., Van Laar, T., Vaessen, R.T.M. and Van der Eb, A. (1985) Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol. Cell. Biol., 5, 3084-3091.
63. Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y. and Oren, M. (1995) A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res., 23, 2584-2592.
64. Zhou, M., Yeager, A.M., Smith, S.D. and Findley, H.W. (1995) Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene. Blood, 85, 1608-1614.