mdmx is a negative regulator of p53 activity in vivo

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3221-3225

  Finch, Rick A ^a   Donoviel, Dorit B ^a   Potter, David ^a   Shi, Min ^a   Fan, Amy ^a   Freed, Deon D ^a   Wang, Ching Yun ^a   Zambrowicz, Brian P ^a   Ramirez Solis, Ramiro ^a   Sands, Arthur T ^a   Zhang, Nan ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PROTEIN MDMX; PROTEIN P53; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO DEVELOPMENT; FIBROBLAST; GENE MUTATION; GENOTYPE; HOMOZYGOTE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; EMBRYO; FIBROBLASTS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036606416     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. MDMX: A novel p53-binding protein with some functional properties of MDM2
2. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
3. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
4. Mapping of the p53 and mdm-2 interaction domains
5. Mdm2 promotes the rapid degradation of p53
6. Regulation of p53 stability by Mdm2
7. MDM2 - Master regulator of the p53 tumor suppressor protein
8. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
9. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
10. MdmX protects p53 from Mdm2-mediated degradation
11. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
12. Rapid allelotype analysis of p53 knockout mice
13. Tumor necrosis factor-α-induced apoptosis in hepatocytes in long-term culture
14. Impaired regulation of nuclear factor-κB results in apoptosis induced by gamma radiation
15. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
16. Proteinuria and perinatal lethality in mice lacking NEPHI, a novel protein with homology to NEPHRIN
17. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
18. Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells
19. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
20. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
21. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
22. Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without P53 mutation or MDM2 amplification