Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells

Journal of the National Cancer Institute

Volumn 89, Issue 20, 1997, Pages 1530-1536

  Schlamp, Cassandra L ^a   Poulsen, Gretchen L ^a   Michael Nork, T ^a   Nickells, Robert W ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; CELL IMMORTALIZATION; DNA SEQUENCE; GENE LOCATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; METASTASIS POTENTIAL; PATHOGENESIS; RETINOBLASTOMA; TUMOR SUPPRESSOR GENE;

EID: 0030779121     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/89.20.1530     Document Type: Article

References (30)

1. Tso MO, Fine BS, Zimmerman LE. The nature of retinoblastoma. II. Photoreceptor differentiation: an electron microscopic study. Am J Ophthalmol 1970;69:350-9.
2. Nork TM, Schwartz TL, Doshi HM, Millecchia LL. Retinoblastoma. Cell of origin. Arch Ophthalmol 1995;113:791-802.
3. Knudson AG Jr. Mutation and childhood cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 1971;68:820-3.
4. Nork TM, Poulsen G, Millecchia LL, Jantz RG, Nickells RW. p53 regulates apoptosis in human retinoblastoma. Arch Ophthalmol 1997; 115:213-9.
5. Shields CL, Shields JA, Baez KA, Cater J, De Potter PV. Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors. Br J Ophthalmol 1993;77:544-8.
6. Muncaster MM, Cohen BL, Phillips RA, Gallie BL. Failure of RB1 to reverse the malignant phenotype of human tumor cell lines. Cancer Res 1992;52:654-61.
7. Al-Ubaidi MR, Font RL, Quiambao AB, Keener MJ, Liou GI, Overbeek PA, et al. Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J Cell Biol 1992;119:1681-7.
8. Albert DM, Griep AE, Lambert PF, Howes KA, Windle JJ, Lasudry JG. Transgenic models of retinoblastoma: what they tell us about its cause and treatment. Trans Am Ophthalmol Soc 1994;92:385-401.
9. Howes KA, Ransom N, Papermaster DS, Lasudry JG, Albert DM, Windle JJ. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53 [published erratum appears in Genes Dev 1994;8:1738]. Genes Dev 1994;8:1300-10.
10. Kato MV, Shimizu T, Ishizaki K, Kaneko A, Yandell DW, Toguchida J, et al. Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Cancer Lett 1996;106:75-82.
11. Bodner SM, Minna JD, Jensen SM, D'Amico D, Carbone D, Mitsudomi T, et al. Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene 1992;7:743-9.
12. Azarian SM, Schlamp CL, Williams DS. Characterization of calpain II in the retina and photoreceptor outer segments. J Cell Sci 1993;105: 787-98.
13. Schlamp CL, Nickells RW, Light and dark cause a shift in the spatial expression of a neuropeptide-processing enzyme in the rat retina. J Neurosci 1996;16:2164-71.
14. Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M. Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J 1985;4:1251-55.
15. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53.
16. Shaulsky G, Goldfinger N, Ben-Ze'ev A, Rotter V. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol Cell Biol 1990;10:6565-77.
17. Brow MA, Oldenburg MC, Lyamichev V, Heisler LM, Lyamicheva N, Hall JG, et al. Differentiation of bacterial 16S rRNA genes and intergenic regions and Mycobacterium tuberculosis katG genes by structure-specific endonuclease cleavage. J Clin Microbiol 1996;34: 3129-37.
18. Resnick-Silverman L, Pang Z, Li G, Jha KK, Ozer HL. Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts. J Virol 1991;65:2845-52.
19. Ulrich E, Boehmelt G, Bird A, Beug H. Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation. Genes Dev 1992;6:876-87.
20. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 1992;256:827-30.
21. Shaulsky G, Goldfinger N, Peled A, Rotter V. Involvement of wild-type p53 protein in the cell cycle requires nuclear localization. Cell Growth Differ 1991;2:661-7.
22. Ryan JJ, Prochownik E, Gottlieb CA, et al. c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci U S A 1994;91: 5878-2.
23. Moll UM, LaQuaglia M, Benard J, Riou G. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci U S A 1995;92:4407-11.
24. Goldman SC, Chen CY, Lansing TJ, Gilmer TM, Kastan MB. The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. Am J Path 1996;148:1381-5.
25. Moll UM, Riou G, Levine AJ. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci U S A 1992;89:7262-6.
26. Baas IO, Mulder JW, Offerhaus GJ, Vogelstein B, Hamilton SR. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J Pathol 1994;172:5-12.
27. Sun XF, Carstensen JM, Zhang H, Stal O, Wingren S, Hatschek T, et al. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 1992;340: 1369-73.
28. Stenmark-Askmalm M, Stal O, Sullivan S, Ferraud L, Sun XF, Carstensen J, et al. Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer. Eur J Cancer 1994;30A:175-80.
29. Lee WH, Murphree AL, Benedict WF. Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 1984;309: 458-60.
30. Squire J, Goddard AD, Canton M, Becker A, Phillips RA, Gallie BL. Tumor induction by the retinoblastoma mutation is independent of N-myc expression. Nature 1986;322:555-7.