Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

EMBO Journal

Volumn 18, Issue 5, 1999, Pages 1223-1234

  Asada, Minoru ^f   Yamada, Takayuki ^f   Ichijo, Hidenori ^a,b   Delia, Domenico ^c   Miyazono, Kohei ^a   Fukumuro, Kenji ^d,e   Mizutani, Shuki ^f  

^a CANCER INSTITUTE   (Japan)

^b Tokyo Medical and Dental University ^*  (Japan)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^f NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Apoptosis; Cell differentiation; Cytoplasmic p21; Nuclear p21

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; CYTOPLASM PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL;

EID: 0033104495     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.5.1223     Document Type: Article

References (36)

1. Andres, V. and Walsh, K. (1996) Myogenin expression, cell cycle withdrawal and phenotypic differentiation are temporally separable events that precedes cell fusion upon myogenesis. J. Cell Biol., 132, 657-666.
2. Bhalla, A.K., Williams, M.M., Lal, S. and Lydyard, P.M. (1989) 1,25-Dihydroxyvitamin D3, but not retinoic acid, induces the differentiation of U937 cells. Clin. Exp. Immunol., 76, 274-277.
3. Canman, C.E., Gilmer, T.M., Coutts, S.B. and Kastan, M.B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9, 600-611.
4. Cardone, M.H., Salvesen, G.S., Widmann, C., Johnson, G. and Frisch, S.M. (1997) The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell, 90, 315-323.
5. Cavigelli, M., Dolfi, F., Claret, F.-X. and Karin, M. (1995). Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J., 14, 5957-5964.
6. Chen, J., Jackson, P.K., Kirschner, M.W. and Dutta, A. (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature, 374, 386-388.
7. El-Deiry, W.S. et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
8. 1 arrest and apoptosis. Cancer Res., 54, 1169-1174.
9. Gorospe, M., Cirielli, C., Wang, X., Seth, P., Capogrossi, M.C. and Holbrook, N.J. (1997) p21 (Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene, 14, 929-935.
10. Guadagno, T.M. and Newport, J.W. (1996) Cdk2 kinase is required for entry into mitosis as a positive regulator of cdc2-cyclin B kinase activity. Cell, 84, 73-82.
11. Halevy, O., Novitch, B.G., Spicer, D.B., Skapek, S.X., Rhee, J., Hannon, G.J., Beach, D. and Lassar, A.B. (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science, 267, 1018-1021.
12. 1 cyclin-dependent kinase. Cell, 75, 805-816.
13. Ichijo, H. et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science, 275, 90-94.
14. Jiang, H., Lin, J., Su,Z.-Z., Collart, F.R., Huberman, E. and Fisher, P.B. (1994) Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene, 9, 3397-3406.
15. Klebanoff, S.J., Locksley, R.M., Jong, E.C. and Rosen, H. (1983) Cytopathology of parasitic disease. In Ciba Foundation Symposium 99 (ed.), Oxidative Response of Phagocytes to Parasite Invasion. Pitman Books, London, UK, pp. 92-112.
16. Kroemer, G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med., 3, 614-620.
17. Kroemer, G., Zamzami, N. and Susin, S.A. (1997) Mitochondrial control of apoptosis. Immunol. Today, 18, 44-51.
18. LaBaer, J., Garrett, M.D., Stevenson, L.F., Slingerland, J.M., Sandhu, C., Chou, H.S., Fattaey, A. and Harlow, E. (1997) New functional activities for the p21 family of CDK inhibitors. Genes Dev., 11, 847-862.
19. Li, Y., Jenkins, C.W., Nichols, M.A. and Xiong, Y. (1994) Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene, 9, 2261-2268.
20. Liu, M., Lee, M.H., Cohen, M., Bommakanti, M. and Freedman, L.P. (1996) Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the differentiation of the myelomonocytic cell line U937. Genes Dev., 10, 142-153.
21. Lubbert, M., Herrmann, F. and Koeffler, H.P. (1991) Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells. Blood, 77, 909-924.
22. Luo, Y., Hurwitz, J. and Massague, J. (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature, 375, 159-161.
23. Marchetti, P. et al. (1996) Mitochondrial permeability transition is a central coordinating event of apoptosis. J. Exp. Med., 184, 1155-1160.
24. Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211, 90-98.
25. Polyak, K., Waldman, T., He, T.-C., Kinzler, K.W. and Vogelstein, B. (1996) Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev., 10, 1945-1952.
26. Cip1/Waf1 in UV-irradiated and transformed cells. Oncogene, 16, 1333-1343.
27. Reichel, H., Koeffler, H.P. and Norman, A.W. (1989) The role of the vitamin D endocrine system in health and disease. N. Engl. J. Med., 320, 980-991.
28. Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K. and Ichijo, H. (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J., 17, 2596-2606.
29. 1 cyclin-dependent kinases. Genes Dev., 9, 1149-1163.
30. Shim, J., Lee, H., Park, J., Kim, H. and Choi, E.-J. (1996) A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature, 381, 804-807.
31. Steinman, R.A., Hoffman, B., Iro, A., Guillouf, C., Liebermann, D.A. and El-Houseini, M.E. (1994) Induction of p21 (WAF1/CIP1) during differentiation. Oncogene, 9, 3389-3396.
32. Susin, S.A., Zamzami, N., Castedo, M., Daugas, E., Wang, H.-G., Geley, S., Fassy, F., Reed, J.C. and Kroemer, G. (1997) The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J. Exp. Med., 186, 25-37.
33. Verheij, M. et al. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380, 75-79.
34. Waga, S., Hannon, G.J., Beach, D. and Stillman, B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369, 574-578.
35. Zhang, H., Hannon, G.J. and Beach, D. (1994) p21-containing cyclin kinases exist in both active and inactive states. Genes Dev., 8, 1750-1758.
36. Zoratti, M. and Szabo, I. (1995) The mitochondrial permeability. Biochim. Biophys. Acta, 1241, 139-176.