The human histone deacetylase family

Experimental Cell Research

Volumn 262, Issue 2, 2001, Pages 75-83

  Gray, Steven G ^a,b   Ekström, Tomas J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b VAN ANDEL RESEARCH INSTITUTE   (United States)

Author keywords

HDA1; HDAC; RPD3; Sir2

Indexed keywords

FUNGAL PROTEIN; HISTONE DEACETYLASE; PROTEIN HDA1; PROTEIN RPD3; SILENT INFORMATION REGULATOR PROTEIN 2; TRICHOSTATIN A; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL PROLIFERATION; DATA BASE; ENZYME ANALYSIS; ENZYME ISOLATION; HUMAN; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; YEAST;

EID: 0035862199     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5080     Document Type: Review

References (103)

1. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
2. Methylation, gene expression and the chromatin connection in cancer
3. Review: Chromatin structural features and targets that regulate transcription
4. Sin meets NuRD and other tails of repression
5. E2F family members are differentially regulated by reversible acetylation
6. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
7. Regulation of E2F transcription by cyclinE-Cdk2 kinase mediated through p300/CBP co-activators
8. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
9. Gene silencing. Methylation meets acetylation
10. CpG methylation, chromatin structure and gene silencing - A three-way connection
11. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
12. Ikaros sets thresholds for T cell activation and regulates chromosome propagation
13. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
14. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
15. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
16. p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription
17. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5
18. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
19. MEF-2 function is modified by a novel co-repressor, MITR
20. HDAC4 deacetylase associates with and represses the MEF2 transcription factor
21. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity
22. Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes
23. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
24. Transcriptional repression by neuron-restrictive silencer factor is mediated via the SIN3-histone deacetylase complex
25. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
26. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
27. DNA damage activates p53 through a phosphorylation-acetylation cascade
28. p53 sites acetylated in vitro by Pcaf and p300 are acetylated in vivo in response to Dna damage
29. Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry
30. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
31. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4
32. Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae
33. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
34. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
35. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells
36. Characterization of a human RPD3 ortholog, HDAC3
37. Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
38. Cloning and characterization of a novel human histone deacetylase, HDAC8
39. Cloning and characterization of human histone deacetylase 8
40. Genomic organization and chromosomal localization of the human histone deacetylase 3 gene
41. Molecular cloning and characterization of the mouse histone deacetylase 1 gene: Integration of a retrovirus in 129SV mice
42. Cloning and characterization of the mouse histone deacetylase-2 gene
43. Histone deacetylases: Silencers for hire
44. A Smad transcriptional corepressor
45. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12
46. The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription
47. 2/M checkpoint Rad proteins
48. Retinoblastoma protein recruits histone deacetylase to repress transcription
49. Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription
50. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins
51. Rb interacts with histone deacetylase to repress transcription
52. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
53. RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein
54. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
55. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
56. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
57. The histone deacetylase-3 complex contains nuclear receptor corepressors
58. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
59. β-Catenin-histone deacetylase interations regulate the transition of LEF1 from a transcriptional repressor to an activator
60. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
61. Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription
62. Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein cut homolog, is associated with histone deacetylation
63. CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein
64. MBP-1 physically associates with histone deacetylase for transcriptional repression
65. Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism
66. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
67. Histone deacetylase 1 can repress transcription by binding to Sp1
68. Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells
69. Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate
70. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene
71. IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin A
72. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
73. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex
74. Three proteins define a class of human histone deacetylases related to yeast Hda1p
75. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p
76. The DNA sequence of human chromosome 22
77. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers
78. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
79. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
80. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
81. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
82. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4
83. Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
84. Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm
85. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
86. Acetylation of importin-alpha nuclear import factors by CBP/p300
87. Sir2 links chromatin silencing, metabolism and aging
88. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
89. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
90. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
91. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
92. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
93. Rad6-dependent ubiquitination of histone H2B in yeast
94. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
95. The conserved core of a human SIR2 homologue functions in yeast silencing
96. +-dependent protein deacetylase activity in the Sir2 protein family
97. The insulin-like growth factor-binding protein (IGFBP) superfamily
98. CCN proteins are distinct from and should not be considered members of the insulin-like growth factor-binding protein superfamily
99. Nuclear hormone receptor coregulators in action: Diversity for shared tasks
100. Acetylation and chromosomal functions
101. Genomic imprinting in mammals: An interplay between chromatin and DNA methylation?
102. Identification and mapping of human histone acetylation modifier gene homologues
103. Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping