Histone acetylation and disease

Cellular and Molecular Life Sciences

Volumn 58, Issue 5-6, 2001, Pages 728-736

  Timmermann, S ^a   Lehrmann, H ^a   Polesskaya, A ^a   Harel Bellan, A ^a  

^a CNRS UPR 9079 Oncogenese Differenciation et Transduction du Signal   (France)

Author keywords

Butyrate; Dietary fiber; Fragile X syndrome; HAT; HDAC; Histone acetylation; Leukemia; TSA

Indexed keywords

BUTYRIC ACID DERIVATIVE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; PROTEIN P300; TRANSCRIPTION FACTOR; TRICHOSTATIN A;

ACETYLATION; CARCINOMA; CELL DIFFERENTIATION; CELL PROLIFERATION; DEVELOPMENTAL DISORDER; FRAGILE X SYNDROME; HUMAN; LEUKEMIA; NONHUMAN; PROTEIN MODIFICATION; REGULATORY MECHANISM; REVIEW; RUBINSTEIN SYNDROME;

EID: 0034968671     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000896     Document Type: Review

References (107)

1. Crystal structure of the nucleosome core particle at 2.8 A resolution
2. Chromatin fiber structure: Morphology, molecular determinants, structural transitions
3. Structure and function of the core histone N-termini: More than meets the eye
4. Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA
5. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin
6. Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III
7. Chromatin and chromosomal controls in development
8. Histone acetylation and X inactivation
9. Histone H4 acetylation analyses in patients with polysomy X: Implications for the mechanism of X inactivation
10. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
11. Regulation of E2F1 activity by acetylation
12. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
13. p300 and CBP: Partners for life and death
14. Phosphorylated CREB binds specifically to the nuclear protein CBP
15. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
16. Histone-like TAFs within the PCAF histone acetylase complex
17. Acetylation regulates transcription factor activity at multiple levels
18. Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins
19. Acetylation of histones and transcription-related factors
20. Drosophila CBP is required for dorsal-dependent twist gene expression
21. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans
22. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
23. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
24. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
25. CBP/p300 in cell growth, transformation, and development
26. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators
27. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
28. MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16) (q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia
29. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
30. Mutations truncating the EP300 acetylase in human cancers
31. p300 gene alterations in colorectal and gastric carcinomas
32. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
33. Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome
34. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein
35. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
36. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
37. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
38. Regulation of E2F1 activity by acetylation
39. Regulation of the specific DNA binding function of p53
40. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
41. DNA damage activates p53 through a phosphorylation-acetylation cascade
42. The transcriptional coactivators p300 and CBP are histone acetyltransferases
43. Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5
44. The PCAF acetylase complex as a potential tumor suppressor
45. Tip60 acetylates six lysines of a specific class in core histones in vitro
46. Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat
47. Tip60 is a nuclear hormone receptor coactivator
48. The Bc1-3 oncoprotein acts as a bridging factor between NF-kappaB/Re1 and nuclear co-regulators
49. Tip60 inhibits activation of CREB protein by protein kinase A
50. Tip60 interacts with human interleukin-9 receptor alpha-chain
51. The translocation t(8;16) (p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
52. A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16)
53. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22)
54. Detection of CBP rearrangements in acute myelogenous leukemia with t(8;16)
55. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
56. Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
57. Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2
58. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
59. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
60. The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex
61. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
62. Steroid receptor coactivator-1 is a histone acetyltransferase
63. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
64. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
65. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
66. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
67. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
68. Predictive value of SRC-1 for tamoxifen response of recurrent breast cancer
69. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer
70. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
71. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
72. Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression
73. Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes
74. Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250
75. Histone deacetylases, transcriptional control, and cancer
76. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
77. c-Myc target genes involved in cell growth, apoptosis and metabolism
78. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
79. Retinoblastoma protein recruits histone deacetylase to repress transcription
80. Rb interacts with histone deacetylase to repress transcription
81. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
82. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
83. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
84. Role of the histone deacetylase complex in acute promyelocytic leukaemia
85. Role of histone deacetylases in acute leukemia
86. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
87. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
88. DNA methyltransferase Dnmt1 associates with histone deacetylase activity
89. DNMT1 binds HDAC2 anda new co-repressor, DMAP1, to form a complex at replication foci
90. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
91. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
92. Cancer epigenetics comes of age
93. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells
94. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
95. Absence of expression of the FMR-1 gene in fragile X syndrome
96. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells
97. Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate
98. Histone deacetylase inhibitors as potential anti-skin cancer agents
99. New agents for acute myelogenous leukemia
100. Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase
101. Phase I trial of interleukin-2 and high-dose arginine butyrate in metastatic colorectal cancer
102. Butyrate, aspirin and colorectal cancer
103. Butyrate production from dietary fibre and protection against large bowel cancer in a rat model
104. Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations
105. Different morphological changes of two colorectal adenocarcinoma cell-lines after sodium butyrate treatment
106. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Ab1 or overexpress MDR, MRP, Bc1-2 or Bc1-x(L)
107. Cyclic dipeptides in the induction of maturation for cancer therapy