Histone acetyltransferases: Function, structure, and catalysis

Current Opinion in Genetics and Development

Volumn 11, Issue 2, 2001, Pages 155-161

  Marmorstein, Ronen ^a,b   Roth, Sharon Y ^c  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE;

ACETYLATION; ANIMAL CELL; CATALYSIS; CELL DIFFERENTIATION; CELL GROWTH; CHEMICAL MODIFICATION; CHROMATIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; GENE ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0035313803     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00173-8     Document Type: Review

References (44)

1. Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis
2. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
3. Acetylation of histones and transcription-related factors
4. Roles of histone acetyltransferases and deacetylases in gene regulation
5. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
6. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
7. Mediator-nucleosome interactions
8. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme
9. The language of covalent histone modifications
10. Acetylation: A regulatory modification to rival phosphorylation
11. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
12. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
13. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
14. Structure and ligand of a histone acetyltransferase bromodomain
15. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases
16. Esa1p is an essential histone acetyltransferase required for cell cycle progression
17. ESA1 is a histone acetyltransferase that is essential for growth in yeast
18. Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila
19. The t(8;16)(p11;p13) translocation of acute myeloid leukemia fuses a putative acetyltransferase to the CREB-binding protein
20. Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
21. Chromodomains are protein-RNA interaction modules
22. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein
23. Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A
24. Structure of tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide
25. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
26. Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
27. Crystal structure of yeast Esa1 suggests a unified mechanism of catalysis and substrate binding by histone acetyltransferases
28. Structure of the histone acetyltransferase Hat1: A paradigm for the GCN5-related N-acetyltransferase superfamily
29. Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator
30. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
31. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
32. Structure and function of a human TAFII250 double bromodomain module
33. The Swi/Snf family of nucleosome-remodeling complexes and transcriptional control
34. Chromatin remodeling: A marriage between two families?
35. Global role for chromatin remodeling enzymes in mitotic gene expression
36. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
37. Loss of GCN512 leads to increased apoptosis and mesodermal defects during mouse development
38. Mutations truncating the EP300 acetylase in human cancers
39. Histone acetylases and deacetylases in cell proliferation
40. Chromatin remodeling and leukemia: New therapeutic paradigms
41. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
42. The PCAF acetylase complex as a potential tumor suppressor
43. Structure and function of the core histone N-termini: More than meets the eye